Abstract: Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The glucose sensor is configured to sense glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed receives signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control of the subject based on desired glucose levels, insulin amount delivered and measured glucose levels of the subject. The controller is also configured to deliver insulin using a tuning factor based on either one of an omission index module or a calibration index module.

Abstract: Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The glucose sensor is configured to sense glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed receives signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control of the subject based on desired glucose levels, insulin amount delivered and measured glucose levels of the subject. The controller is also configured to deliver insulin using a tuning factor based on either one of an omission index module or a calibration index module.

Abstract: An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated such as cerebrospinal fluid.

Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

Abstract: An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated (such as cerebrospinal fluid).

Abstract: An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated (such as cerebrospinal fluid).

Abstract: A method for reducing or preventing a human brain disorder relating to the presence of a pathogenic substance in cerebrospinal fluid by selecting a human for treatment as a patient and placing a proximal end of a first catheter, having at least a first lumen, in a first sub-dural location within the brain of the patient to establish open communication between the first lumen and cerebrospinal fluid of the patient. For an extended period of time, a curcumin agent selected from at least one of curcumin, a curcumin hybrid and a curcumin analog is delivered to the cerebrospinal fluid to interact with the pathogenic substance to attenuate its effect on the brain.

Abstract: A hydrophilic coated stylette is pre-loaded in an implantable catheter. The hydrophilic coated stylette is wetted with saline to activate the hydrophilic coating. The stylette loaded catheter is tunneled, typically through muscle and tissue, to a desired target site within the body. The hydrophilic coated stylette is then removed from the catheter while maintaining the catheter intact. The proximal end of the catheter can be connected to an outlet of an implantable infusion pump so that medicament can be delivered directly to the target site.

Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

Abstract: A hydrophilic coated stylette is pre-loaded in an implantable catheter. The hydrophilic coated stylette is wetted with saline to activate the hydrophilic coating. The stylette loaded catheter is tunneled, typically through muscle and tissue, to a desired target site within the body. The hydrophilic coated stylette is then removed from the catheter while maintaining the catheter intact. The proximal end of the catheter can be connected to an outlet of an implantable infusion pump so that medicament can be delivered directly to the target site.

Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

Abstract: A stent device is provided. The stent device includes a helical structure. The stent device also includes a ring structure connected to the helical structure. The ring structure includes an inner conducting ring, an outer conducting ring, and a dielectric material disposed between the inner and outer conducting rings. The stent device radiates an induced electromagnetic field when subjected to an applied electromagnetic field.