Patents by Inventor Ramakrishnan Vishwanath
Ramakrishnan Vishwanath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230303970Abstract: The invention encompasses methods for reducing the proportion of sperm cells with abnormal morphology, and unviable sperm cells, in a sperm cell population.Type: ApplicationFiled: April 13, 2023Publication date: September 28, 2023Applicant: Inguran, LLCInventors: Juan Moreno, Kenneth Michael Evans, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Patent number: 11629330Abstract: The invention encompasses methods for reducing the proportion of sperm cells with abnormal morphology, and unviable sperm cells, in a sperm cell population.Type: GrantFiled: March 18, 2020Date of Patent: April 18, 2023Assignee: Inguran, LLCInventors: Juan Moreno, Kenneth Michael Evans, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Publication number: 20230097054Abstract: The present invention relates to compositions comprising low sugar media, the methods of using these compositions to reduce trauma and stress on processed animal sperm, the resulting sperm and embryo products, and the methods of use of these products to increase the quality, quantity and viability of progeny and improved rates of births in animals.Type: ApplicationFiled: April 15, 2022Publication date: March 30, 2023Applicant: Inguran, LLCInventors: Thomas B. Gilligan, Ramakrishnan Vishwanath, Kilby Willenburg
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Patent number: 11448653Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.Type: GrantFiled: March 2, 2020Date of Patent: September 20, 2022Assignee: Inguran, LLCInventors: Kenneth Michael Evans, Thomas Boyd Gilligan, Richard W. Lenz, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Publication number: 20220186182Abstract: Embodiments of the present invention relate generally to processes, systems, and compositions useful in manipulating a ratio of viable X chromosome bearing sperm to viable Y chromosome bearing sperm in at least one sperm population and useful for preserving the resulting manipulated sperm population. In some embodiments a cryoprotectant may be incorporated into various medias used in manipulating the sperm sample, such as in a staining media, a sheath fluid, and a collection media.Type: ApplicationFiled: February 7, 2022Publication date: June 16, 2022Applicant: Inguran, LLCInventors: Thomas B. Gilligan, Clara Gonzalez-Marin, Ramakrishnan Vishwanath
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Patent number: 11326146Abstract: The present invention relates to compositions comprising low sugar media, the methods of using these compositions to reduce trauma and stress on processed animal sperm, the resulting sperm and embryo products, and the methods of use of these products to increase the quality, quantity and viability of progeny and improved rates of births in animals.Type: GrantFiled: November 20, 2015Date of Patent: May 10, 2022Assignee: Inguran, LLCInventors: Thomas B. Gilligan, Ramakrishnan Vishwanath, Kilby Willenburg
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Patent number: 11279913Abstract: Embodiments of the present invention relate generally to processes, systems, and compositions useful in manipulating a ratio of viable X chromosome bearing sperm to viable Y chromosome bearing sperm in at least one sperm population and useful for preserving the resulting manipulated sperm population. In some embodiments a cryoprotectant may be incorporated into various medias used in manipulating the sperm sample, such as in a staining media, a sheath fluid, and a collection media.Type: GrantFiled: January 19, 2018Date of Patent: March 22, 2022Assignee: Inguran, LLCInventors: Thomas B. Gilligan, Clara Gonzalez-Marin, Ramakrishnan Vishwanath
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Patent number: 10932451Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: GrantFiled: December 23, 2019Date of Patent: March 2, 2021Assignee: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Publication number: 20200299640Abstract: The invention encompasses methods for reducing the proportion of sperm cells with abnormal morphology, and unviable sperm cells, in a sperm cell population.Type: ApplicationFiled: March 18, 2020Publication date: September 24, 2020Applicant: Inguran, LLCInventors: Juan Moreno, Kenneth Michael Evans, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Publication number: 20200200762Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.Type: ApplicationFiled: March 2, 2020Publication date: June 25, 2020Applicant: Inguran, LLCInventors: Kenneth Michael Evans, Thomas Boyd Gilligan, Richard W. Lenz, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Publication number: 20200128795Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Applicant: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Patent number: 10620213Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.Type: GrantFiled: October 3, 2013Date of Patent: April 14, 2020Assignee: Inguran, LLCInventors: Kenneth Michael Evans, Thomas Boyd Gilligan, Richard W. Lenz, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
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Patent number: 10563170Abstract: The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly collected, those transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a health embryo and produce a healthy offspring.Type: GrantFiled: April 17, 2018Date of Patent: February 18, 2020Assignee: Inguran, LLCInventors: Richard Lenz, Juan Moreno, Ramakrishnan Vishwanath
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Patent number: 10555504Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: GrantFiled: July 10, 2019Date of Patent: February 11, 2020Assignee: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Publication number: 20190327939Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: ApplicationFiled: July 10, 2019Publication date: October 31, 2019Applicant: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Patent number: 10400213Abstract: This disclosure relates to cell sorting methods, and particularly cell sorting methods that improve the efficiency or productivity of sorting in a particle sorting instrument utilizing a measured parameter of sorting efficiency. In one embodiment, minimum productivity and minimum purity may be established and maintained while attempting to maximize the sorting efficiency. While in another embodiment, a minimum sorting efficiency and a minimum purity may be established and maintained while attempting to maximize the productivity of a sort.Type: GrantFiled: March 4, 2013Date of Patent: September 3, 2019Assignee: Inguran, LLCInventors: Kenneth Michael Evans, Thomas Boyd Gilligan, Johnathan Charles Sharpe, Juan Moreno, Ramakrishnan Vishwanath
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Patent number: 10349632Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: GrantFiled: August 7, 2017Date of Patent: July 16, 2019Assignee: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Patent number: 10226041Abstract: The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly collected, those transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a health embryo and produce a healthy offspring.Type: GrantFiled: August 17, 2017Date of Patent: March 12, 2019Assignee: Inguran, LLCInventors: Richard Lenz, Juan Moreno, Ramakrishnan Vishwanath
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Patent number: 10080348Abstract: Exemplary embodiments are directed to sensor apparatuses for attachment to an animal that include a housing and a sensor assembly. The housing can be attachable to the animal and includes an internal cavity formed therein. The sensor assembly can be disposed within the internal cavity of the housing. The sensor assembly includes a force sensor and an accelerometer arranged to detect force data and accelerometer data representative of a physiological state of the animal. Exemplary embodiments are also directed to method and sensor systems for detecting a physiological state of an animal.Type: GrantFiled: May 20, 2014Date of Patent: September 25, 2018Assignee: ST Reproductive Technologies, LLCInventors: Johnathan Charles Sharpe, Philip Rowe, Ramakrishnan Vishwanath, Paul Julian Martinsen
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Publication number: 20180237747Abstract: The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly collected, those transported as fresh samples, as well as samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the sperm cell. Such trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the sperm's ability to fertilize an egg, grow into a health embryo and produce a healthy offspring.Type: ApplicationFiled: April 17, 2018Publication date: August 23, 2018Applicant: Inguran, LLCInventors: Richard Lenz, Juan Moreno, Ramakrishnan Vishwanath