Patents by Inventor Ramani R. Raghavan

Ramani R. Raghavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
    Patent number: 8076479
    Abstract: Disclosed is a process for the synthesis of compounds of Formula I by sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1, wherein R1 is a linear, branched, or cyclic alkyloxy functional group of the structure (—R2a—OH), R2a is a linear, branched or cyclic alkyl group, R2 is a linear, branched or cyclic alkyl group, and R3 is an alkylene-heterocycle, said process comprising forming intermediate compound of Formula E1 by reacting, in a refluxing reaction solvent selected from alcohols having 5 or less carbon atoms and mixtures of two or more thereof, a methanol solution of a salt of a 4-alkyl-3-amino-pyrazole compound of Formula C1, with a diamidization reagent selected from dimethylmalonate, monomethylmalonyl-chloride, and malonyl dichloride in the presence of a Lewis base having sufficient proton affinity to abstract a proton from the 1-position nitrogen on the pyrazole ring.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: December 13, 2011
    Assignee: Schering Corporation
    Inventors: Frank Xing Chen, Kartik M. Keertikar, Shen-Chun Kuo, Hong-Chang Lee, Ramani R. Raghavan, George G. Wu, Ji Xie
  • Process and intermediates for the preparation of (1,2,5)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Patent number: 7728165
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: June 1, 2010
    Assignee: Schering Plough Corporation
    Inventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE
    Publication number: 20100113821
    Abstract: Disclosed is a process for preparing 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide hydrochloride, an intermediate useful in the preparation of the HCV protease inhibitor (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide.
    Type: Application
    Filed: December 17, 2007
    Publication date: May 6, 2010
    Applicant: Schering-Plough Corporation
    Inventors: Jeonghan Park, Eugene J. Vater, Shuan Dong, Tetsuo Iwama, Ramani R. Raghavan, Hong-Chang Lee, George S.k. Wong
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF
    Publication number: 20090247784
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Application
    Filed: June 15, 2009
    Publication date: October 1, 2009
    Inventors: Jeonghan Park, Anantha R. Sudhakar, George S. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-Jong Kwok, Ingyu Jeon, Ramani R. Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof
    Patent number: 7569705
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: August 4, 2009
    Assignee: Schering Corporation
    Inventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Synthesis of (4-bromophenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
    Patent number: 7524963
    Abstract: In one embodiment, the present invention describes the synthesis of (4-bromophenyl) (4-piperidyl)methanone-(Z)-O-ethyloxime and its acid salts, and similar compounds, in high stereochemical purity.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: April 28, 2009
    Assignee: Schering Corporation
    Inventors: George S. K. Wong, Jeonghan Park, Weidong Tong, Ramani R. Raghavan
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Patent number: 7309717
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: December 18, 2007
    Assignee: Schering Corporation
    Inventors: Jeonghan Park, Anantha Sudhakar, George S. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-Jong Kwok, Ingyu Jeon, Ramani R. Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
    Publication number: 20030092731
    Abstract: In one embodiment, the present invention describes the synthesis of (4-bromophenyl) (4-piperidyl)methanone-(Z)-O-ethyloxime and its acid salts, and similar compounds, in high stereochemical purity.
    Type: Application
    Filed: October 11, 2002
    Publication date: May 15, 2003
    Applicant: SCHERING CORPORATION
    Inventors: George S.K. Wong, Jeonghan Park, Weidong Tong, Ramani R. Raghavan