Patents by Inventor Ramani Susarla

Ramani Susarla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
    Patent number: 10646452
    Abstract: The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: May 12, 2020
    Assignees: New Jersey Institute of Technology, Rutgers, The State University of New Jersey
    Inventors: Rajesh N. Dave, Ramani Susarla, Boris Khusid, Anagha A. Bhakay, Ecevit A. Bilgili, Fernando Muzzio
  • System and Method for Fabrication of Uniform Polymer Films Containing Nano and Micro Particles via Continuous Drying Process
    Publication number: 20160022599
    Abstract: The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGY
    Inventors: Rajesh N. Dave, Ramani Susarla, Boris Khusid, Anagha A. Bhakay, Ecevit A. Bilgili, Fernando Muzzio