Patents by Inventor Ramanuj Dasgupta

Ramanuj Dasgupta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200218874
    Abstract: Disclosed herein are methods of providing a computational model for predicting an activity of a test agent with respect to a 3D cell structure. Also disclosed herein are label-free prediction methods and a device configured to perform the methods as disclosed herein.
    Type: Application
    Filed: August 14, 2018
    Publication date: July 9, 2020
    Inventors: Lie Yong Judice Koh, Ramanuj Dasgupta, Giridharan Periyasamy
  • Patent number: 9874553
    Abstract: A novel method which integrates a “sensitized” chemical genetic high-throughput screen (HTS) with RNA interference (RNAi) screening technology is described herein. The present inventors used this method to identify specific small molecule inhibitors and activators of the Wnt pathway. More particularly, the screening method of the present invention may be used to identify small molecule inhibitors and activators that specifically target the activity of a stabilized pool of ?-catenin. A number of compounds identified using the instant method, are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat. The inhibitors identified by the present method may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: January 23, 2018
    Assignee: New York University
    Inventors: Ramanuj Dasgupta, Foster Gonsalves
  • Publication number: 20170355686
    Abstract: Oxazole compounds according to formula I: are provided as inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and other conditions related to Wnt pathway dysfunction, including pulmonary fibrosis.
    Type: Application
    Filed: November 17, 2015
    Publication date: December 14, 2017
    Inventors: Ramanuj DASGUPTA, Gavara Govinda RAJULU, John K. DICKSON
  • Publication number: 20170049751
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: September 1, 2016
    Publication date: February 23, 2017
    Inventors: Ramanuj DASGUPTA, Foster GONSALVES
  • Patent number: 9433611
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 6, 2016
    Assignee: New York University
    Inventors: Ramanuj Dasgupta, Foster Gonsalves
  • Patent number: 9173871
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: November 3, 2015
    Assignee: New York University
    Inventors: Ramanuj Dasgupta, Foster Gonsalves, Susan Katherine Logan, Eugine Lee
  • Publication number: 20150267193
    Abstract: MicroRNAs (miRs) and methods and uses thereof for modulating Wnt signaling pathways are described herein.
    Type: Application
    Filed: October 15, 2012
    Publication date: September 24, 2015
    Inventor: Ramanuj Dasgupta
  • Publication number: 20130109675
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: August 27, 2012
    Publication date: May 2, 2013
    Inventors: Ramanuj Dasgupta, Foster Gonsalves
  • Publication number: 20120264744
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: April 17, 2012
    Publication date: October 18, 2012
    Inventors: Ramanuj DASGUPTA, Foster GONSALVES, Susan Katherine LOGAN, Eugine LEE
  • Patent number: 8252823
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: August 28, 2012
    Assignee: New York University
    Inventors: Ramanuj Dasgupta, Foster Gonsalves
  • Publication number: 20110251103
    Abstract: A novel method which integrates a “sensitized” chemical genetic high-throughput screen (HTS) with RNA interference (RNAi) screening technology is described herein. The present inventors used this method to identify specific small molecule inhibitors and activators of the Wnt pathway. More particularly, the screening method of the present invention may be used to identify small molecule inhibitors and activators that specifically target the activity of a stabilized pool of ?-catenin. A number of compounds identified using the instant method, are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat. The inhibitors identified by the present method may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: September 10, 2009
    Publication date: October 13, 2011
    Inventors: Ramanuj Dasgupta, Foster Gonsalves
  • Publication number: 20090227624
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-cat oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: January 28, 2009
    Publication date: September 10, 2009
    Inventors: Ramanuj Dasgupta, Foster Gonsalves