Abstract: Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.

Abstract: The present disclosure relates to methods and formulations for treating respiratory viral infections by administering a statin by inhalation.

Abstract: This disclosure relates generally to method and system for structure-based drug design using a multi-modal deep learning model. The method processes a target protein for designing at least one optimized molecule by using a multi-modal deep learning model. The GAT-VAE module obtains a latent vector of at least one active site graph comprising of key amino acid residues from the target protein. The SMILES-VAE module obtains at least one latent vector from the target protein. Further, the conditional molecular generator concatenates the active site graph with the latent vector to generate a set of molecules. The RL framework is iteratively performed on the concatenated latent vector to optimize at least one molecule by using the drug-target affinity (DTA) predictor module to predict an affinity value for the set of molecules towards the target protein. Further, at least one optimized molecule is designed with an affinity of the target protein.

Abstract: present disclosure relates to methods for relaxing airway smooth muscle tissue, alleviating or preventing bronchospasm, and treating lung diseases by administering an HMG-CoA reductase inhibitor (statin) directly to lung tissue by inhalation. The disclosure also relates to formulations and compositions useful for the practice of methods of the disclosure.

Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Abstract: Conventionally, deep learning-based methods have shown some success in ligand-based drug design. However, these methods face data scarcity problems while designing drugs against novel targets. Embodiments of the present disclosure provide systems and methods that leverage the potential of deep learning and molecular modeling approaches to develop a drug design pipeline, which can be useful for cases where there is limited or no availability of target-specific ligand datasets. Inhibitors of other proteins, structurally similar to the target protein are screened at the active site of the target protein to create an initial target-specific dataset. Transfer learning is implemented to learn features of target-specific dataset and design new chemical entities/molecules using a deep generative model. A deep predictive model is used predict docking scores of newly designed/identified molecules.

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

Abstract: A platform for biological assays includes a base substrate providing structural support to the platform, at least one surface of the base substrate coated with position markers, a first deformable layer positioned on top of the base substrate, and a second deformable layer positioned on top of the first deformable layer, the second deformable layer embedded with deformation markers.

Abstract: Techniques for application activation are described herein. An operating system (OS) can be configured to incorporate various extension points that are serviceable through contracts defining individual invocations of extensible functionality. The extensible functionality is integrated as part of the OS and controlled by the OS in a centralized manner. However, the specific implementations of the extensible functionally are offloaded to applications using the contracts. For example, the OS can include or otherwise make use of a centralized application activation component that employs an object-oriented approach to invoke applications to perform particular contracts. The application activation component can pass information describing a particular contract to activate a designated application and enable the application to service the contract in the manner specified by the OS.

Abstract: Techniques for application activation are described herein. An operating system (OS) can be configured to incorporate various extension points that are serviceable through contracts defining individual invocations of extensible functionality. The extensible functionality is integrated as part of the OS and controlled by the OS in a centralized manner. However, the specific implementations of the extensible functionally are offloaded to applications using the contracts. For example, the OS can include or otherwise make use of a centralized application activation component that employs an object-oriented approach to invoke applications to perform particular contracts. The application activation component can pass information describing a particular contract to activate a designated application and enable the application to service the contract in the manner specified by the OS.

Abstract: Techniques for application activation are described herein. An operating system (OS) can be configured to incorporate various extension points that are serviceable through contracts defining individual invocations of extensible functionality. The extensible functionality is integrated as part of the OS and controlled by the OS in a centralized manner. However, the specific implementations of the extensible functionally are offloaded to applications using the contracts. For example, the OS can include or otherwise make use of a centralized application activation component that employs an object-oriented approach to invoke applications to perform particular contracts. The application activation component can pass information describing a particular contract to activate a designated application and enable the application to service the contract in the manner specified by the OS.

Abstract: Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.

Abstract: A platform for biological assays includes a base substrate providing structural support to the platform, at least one surface of the base substrate coated with position markers, a first deformable layer positioned on top of the base substrate, and a second deformable layer positioned on top of the first deformable layer, the second deformable layer embedded with deformation markers.

Abstract: Techniques for application activation are described herein. An operating system (OS) can be configured to incorporate various extension points that are serviceable through contracts defining individual invocations of extensible functionality. The extensible functionality is integrated as part of the OS and controlled by the OS in a centralized manner. However, the specific implementations of the extensible functionally are offloaded to applications using the contracts. For example, the OS can include or otherwise make use of a centralized application activation component that employs an object-oriented approach to invoke applications to perform particular contracts. The application activation component can pass information describing a particular contract to activate a designated application and enable the application to service the contract in the manner specified by the OS.

Abstract: Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.