Patents by Inventor Ramaswamy Murari
Ramaswamy Murari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050013924Abstract: A method is disclosed for formulating healthcare products, including solid pharmaceutical compositions, while avoiding instability caused ba interaction of the active ingredient with excipients. The method comprises the steps of: (a) selecting an active ingredient that loses stability or potency upon interaction with pharmaceutical excipients; and (b) depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate.Type: ApplicationFiled: July 6, 2001Publication date: January 20, 2005Inventors: Ramaswamy Murari, Ashok Katdare, Suggy Chrai, Troy Harmon
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Patent number: 6844048Abstract: Provided is, among other things, a conductive inlay film comprising: a layer of dielectric film having a pattern of holes suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element comprising polymer, which element comprises (a) a conductive film laminated against the dielectric film or (b) a conductive film embedded within the holes, the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element is adapted to contact one or more electrode pads and provide electrical potentials at the selected regions, and wherein the dielectric film electrically isolates the selected regions.Type: GrantFiled: July 11, 2001Date of Patent: January 18, 2005Assignee: Sarnoff CorporationInventors: Ramaswamy Murari, Jen-Chi Chen, Suggy S. Chrai
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Publication number: 20040115276Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: ApplicationFiled: March 28, 2003Publication date: June 17, 2004Applicant: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Patent number: 6702803Abstract: Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.Type: GrantFiled: January 22, 2001Date of Patent: March 9, 2004Assignee: Delsys Pharmaceutical CorporationInventors: Gary Kupperblatt, Marc S. Karetny, Ramaswamy Murari, Suggy S. Chrai
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Publication number: 20030200922Abstract: Provided, among other things, is a re-circulating particle feed apparatus comprising: a circular conduit of dimensions suitable for circulating gas with suspended particles; a deposition station comprising an opening onto the conduit, into which opening an electrostatic chuck fits, with a deposition surface of the chuck available to the interior of the conduit; and a propulsion device for maintaining fluid and particle circulation through the conduit, wherein the propulsion device is adapted to maintain fluid and particle circulation at a rate that brings a deposition effective amount of particles within a range of electro-attractive influence at the deposition station.Type: ApplicationFiled: April 29, 2003Publication date: October 30, 2003Applicant: Delsys Pharmaceutical CorporationInventors: George R. Pawlo, Gary Santonastaso, David Keller, Ramaswamy Murari, Suggy S. Chrai
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Patent number: 6616932Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: GrantFiled: September 23, 1999Date of Patent: September 9, 2003Assignee: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari
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Publication number: 20030108601Abstract: A liquid pharmaceutical for oral delivery wherein at the time of use, a solid unit dosage form is added to the liquid wherein the unit dosage form is comprised of a substrate soluble in the liquid and a particulate pharmaceutically active material in a pharmaceutically effective amount. At the time of use, the unit dosage form is added to the liquid, without requiring measurement of the liquid, and the entire liquid is consumed to provide for oral delivery of the pharmaceutically effective amount of material.Type: ApplicationFiled: September 23, 1999Publication date: June 12, 2003Inventors: SUGGY S. CHRAI, RAMASWAMY MURARI
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Patent number: 6527138Abstract: A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamplike (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing.Type: GrantFiled: April 15, 2002Date of Patent: March 4, 2003Assignee: Delsys Pharmaceutical Corp.Inventors: George R. Pawlo, Gary Santonastaso, Ramaswamy Murari, Suggy Chrai
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Publication number: 20030012926Abstract: Provided is, among other things, a conductive inlay film comprising: a layer of dielectric film having a pattern of holes suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element comprising polymer, which element comprises (a) a conductive film laminated against the dielectric film or (b) a conductive film embedded within the holes, the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element is adapted to contact one or more electrode pads and provide electrical potentials at the selected regions, and wherein the dielectric film electrically isolates the selected regions.Type: ApplicationFiled: July 11, 2001Publication date: January 16, 2003Inventors: Ramaswamy Murari, Jen-Chi Chen, Suggy S. Chrai
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Publication number: 20020108963Abstract: A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamp-like (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing.Type: ApplicationFiled: April 15, 2002Publication date: August 15, 2002Inventors: George R. Pawlo, Gary Santonastaso, Ramaswamy Murari, Suggy Chrai
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Publication number: 20020077364Abstract: A method is disclosed for formulating a solid dosage of thyroid hormone, while avoiding instability caused by interaction of the active ingredient with excipients. The thyroid hormone may be levothyroxine sodium or triiodothyronine. The method comprises depositing the active ingredient, preferably electrostatically, as a dry powder substantially free of excipients, onto a pharmaceutically acceptable polymer substrate. Solid pharmaceutical dosage forms also are disclosed.Type: ApplicationFiled: July 6, 2001Publication date: June 20, 2002Inventors: Ramaswamy Murari, Suggy S. Chrai
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Publication number: 20020072735Abstract: Controlled release, multi-step drug dosage forms comprising a plurality of dose units and a plurality of separators that control release of drug from the dose units. In one embodiment, a dose unit is a single dosage amount of a drug that is electrostatically deposited onto a substrate. The dosage forms are designed to deliver a drug to exhibit a desired pharmacokinetic profile.Type: ApplicationFiled: January 22, 2001Publication date: June 13, 2002Inventors: Gary Kupperblatt, Marc S. Karetny, Ramaswamy Murari, Suggy S. Chrai
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Patent number: 6394306Abstract: A dispenser for storing/dispensing pharmaceutical dosages that are provided in a stamp-like (flat) dosage form. In some embodiments, the present dispenser includes a housing for retaining a plurality of stacked, individual “stamp-like” pharmaceutical dosages. Disposed within the housing beneath the dosages is a bias element, such as a helical spring, that urges the dosages towards a dosage delivery port of the housing. From the dosage delivery port, dosages are dispensed through an aperture. In other embodiments, the instant dispenser includes a cylindrical main body for retaining pharmaceutical dosages having a stamp-like dosage form that are collectively organized in a roll. A dosage delivery port depending from the cylindrical main body receives dosages one at a time therefrom. The present dispenser is configured, in various embodiments, for manual, mechanically assisted, or automated dispensing.Type: GrantFiled: June 23, 2000Date of Patent: May 28, 2002Assignee: Delsys Pharmaceutical Corp.Inventors: George R. Pawlo, Gary Santonastaso, Ramaswamy Murari, Suggy Chrai
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Publication number: 20020036154Abstract: A novel solid pharmaceutical dosage formulation of hydrophobic drugs is disclosed, which provides enhanced dissolution and improved bioavailability.Type: ApplicationFiled: August 9, 2001Publication date: March 28, 2002Inventors: Ramaswamy Murari, Suggy S. Chrai, Jen-Chi Chen, Ashok Kadare, Gregory E. Parry, Marc S. Karetny
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Publication number: 20010033863Abstract: A substrate is robotically picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.Type: ApplicationFiled: January 31, 2001Publication date: October 25, 2001Applicant: Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari, Eugene Samuel Poliniak, Hoi Cheong Steve Sun, Nitin Vithalbhai Desai, Dominic Stephen Rosati, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, David Keller, Peter John Zanzucchi, Aaron William Levine, Prince Lal
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Patent number: 6303143Abstract: A substrate is roboticaly picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.Type: GrantFiled: June 10, 1998Date of Patent: October 16, 2001Assignees: Sarnoff Corporation, Delsys Pharmaceutical CorporationInventors: Suggy S. Chrai, Ramaswamy Murari, Eugene Samuel Poliniak, Hoi Cheong (Steve) Sun, Nitin Vithalbhai Desai, Dominic Stephen Rosati, Nalin Kumar, William Ronald Roach, Lawrence Harrison Hammer, Peter David Southgate, Bawa Singh, Howard Christopher Rivenburg, David Keller, Peter John Zanzucchi, Aaron William Levine, Prince Lal