Abstract: The present invention relates to novel pharmaceutical compositions comprising palbociclib, as the as a pharmaceutically active compound. Specifically, the present invention relates to solid dosage forms of palbociclib comprising at least one compound selected from the group consisting of sulphur-containing amino acid or peptide, and at least one vitamin having antioxidant properties. The dosage forms described herein are chemically stable oral preparations having desirable pharmacokinetic characteristics and dissolution properties. The invention is also directed to the use of said pharmaceutical compositions as medicament, in particular for the treatment of cancer.

Abstract: The present disclosure relate to a method and system to assign resources for development of a pharmaceutical product. The method comprises receiving one or more inputs associated with the pharmaceutical product from a user and determining a complexity score of the pharmaceutical product based on the one or more inputs received. The method further comprises classifying the pharmaceutical product based on the complexity score and determining a timeline for development of the pharmaceutical product based on the classification. The method also comprises assigning the resources for development of the pharmaceutical product based on the determination, wherein the resources include at least one of project members and equipment's required for development of the pharmaceutical product.

Abstract: The present invention provides a topical composition of Apremilast with lipohilic agents. The plurality of excipients each present in amounts, and in combination, to effectively control the release of Apremilast from the composition for better penetration in to the skin. The present invention also provides a process for preparation of the apremilast topical composition with enhanced skin penetration and efficacy. The present invention also relates to a method of treating psoriasis and other related skin condition using a lipophilic topical composition of Apremilast, wherein the permeation of Apremilast through the skin is significantly enhanced with the use of lipophilic components in the composition.

Abstract: The present invention relates to a novel topical pharmaceutical composition of Teriflunomide, comprising teriflunomide or its pharmaceutically acceptable salt in combination with pharmaceutically acceptable excipients, wherein the said composition is effective for use in treatment of pain associated with disorders like inflammation and arthritis. The composition is also useful for relieving the symptoms of pain and arthritis in subjects suffering from autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The said topical composition of teriflunomide is prepared in the form of topical gel, topical cream, topical ointment, topical solution, lotion or topical spray with significantly enhanced permeability and diffusion rate of the drug.