Patents by Inventor Ramee Lee

Ramee Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for inhibiting apoptosis through the p75 neurotrophin receptor
    Patent number: 8034347
    Abstract: The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the protein and a vector containing the nucleic acid molecule. The present invention further provides a method for cleaving a proneurotrophin protein to a mature neurotrophin. In addition, the invention relates to methods for inducing apoptosis in a cell of a mammal expressing p75 surface receptors or p75 and trk receptors. The methods include causing the p75 receptor to bind a pharmaceutical composition containing a pro-domain of a proneurotrophin or administering to the mammal an effective amount of a cleavage-resistant proneurotrophin and an inhibitor of trk activation.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: October 11, 2011
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Barbara L. Hempstead, Ramee Lee, Kenneth K. Teng, Pouneh Kermani
  • High affinity ligand for p75 neurotrophin receptor
    Patent number: 7507799
    Abstract: The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the protein and a vector containing the nucleic acid molecule. The present invention further provides a method for cleaving a proneurotrophin protein to a mature neurotrophin. In addition, the invention relates to methods for inducing apoptosis in a cell of a mammal expressing p75 surface receptors or p75 and trk receptors. The methods include causing the p75 receptor to bind a pharmaceutical composition containing a pro-domain of a proneurotrophin or administering to the mammal an effective amount of a cleavage-resistant proneurotrophin and an inhibitor of trk activation.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: March 24, 2009
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Barbara L. Hempstead, Ramee Lee, Kenneth K. Teng, Pouneh Kermani
  • High affinity ligand for p75 neurotrophin receptor
    Publication number: 20080025978
    Abstract: The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the protein and a vector containing the nucleic acid molecule. The present invention further provides a method for cleaving a proneurotrophin protein to a mature neurotrophin. In addition, the invention relates to methods for inducing apoptosis in a cell of a mammal expressing p75 surface receptors or p75 and trk receptors. The methods include causing the p75 receptor to bind a pharmaceutical composition containing a pro-domain of a proneurotrophin or administering to the mammal an effective amount of a cleavage-resistant proneurotrophin and an inhibitor of trk activation.
    Type: Application
    Filed: July 27, 2007
    Publication date: January 31, 2008
    Inventors: Barbara Hempstead, Ramee Lee, Kenneth Teng, Pouneh Kermani
  • High affinity ligand for p75 neurotrophin receptor
    Publication number: 20030087804
    Abstract: The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the protein and a vector containing the nucleic acid molecule. The present invention further provides a method for cleaving a proneurotrophin protein to a mature neurotrophin. In addition, the invention relates to methods for inducing apoptosis in a cell of a mammal expressing p75 surface receptors or p75 and trk receptors. The methods include causing the p75 receptor to bind a pharmaceutical composition containing a pro-domain of a proneurotrophin or administering to the mammal an effective amount of a cleavage-resistant proneurotrophin and an inhibitor of trk activation.
    Type: Application
    Filed: May 24, 2002
    Publication date: May 8, 2003
    Inventors: Barbara L. Hempstead, Ramee Lee, Kenneth K. Teng, Pouneh Kermani