Abstract: The present invention provides an improved method of stabilizing of 3-isothiazolone solutions using bromate compounds by buffering the pH of the solution in the range of 4 to 5.1, and compositions which comprise 3-isothiazolone compound, bromate compound stabilizer, and sufficient buffer to maintain the pH in said range.

Abstract: Process for producing substantially separated 5-chloro-2-methyl-3-isothiazolone (CMI) and 2-methyl-3-isothiazolone (MI) from a mixture of their hydrochloride salts, or in a special mixture having a higher ratio of CMI to MI, comprising heating a mixture of CMI.HCl and MI.HCl for a period of time necessary to fully dissociate said CMI.HCl and form substantially pure CMI, but insufficient to fully dissociate said MI.HCl.

Abstract: Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.

Abstract: Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.

Abstract: A composition comprising(a) a 3-isothiazolone compound of the formula ##STR1## wherein R and R.sup.1 are independently selected from hydrogen, halogen or R is a (C.sub.1 -C.sub.4) alkyl group and R.sup.1 is a halogen or R and R.sup.1 may be joined to form an unsaturated 5- or 6-membered carbocyclic ring; Y is hydrogen, a (C.sub.1 -C.sub.18) alkyl group, an unsubstituted or halo-substituted alkenyl or alkynyl of 2 to 8 carbon atoms, a cycloalkyl or substituted cycloalkyl of 3 to 12 carbon atoms, an aralkyl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aralkyl of up to 10 carbon atoms, or an aryl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aryl group of up to 10 carbon atoms; and(b) an amount of a metal bromate salt sufficient to stabilize said composition;wherein said composition if free of metal nitrate salt is disclosed. Methods of use of the above compositions are also disclosed.

Abstract: An improved process for preparing a 3-isothiazolone of the formula ##STR1## wherein R and R.sup.1 are independently selected from hydrogen, halogen or R is a (C.sub.1 -C.sub.4) alkyl group and R.sup.1 is a halogen; Y is hydrogen, a (C.sub.1 -C.sub.18) alkyl group, an unsubstituted or halo-substituted (C.sub.2 -C.sub.8) alkenyl or alkynyl, a cycloalkyl or substituted (C.sub.3 -C.sub.12) cycloalkyl, an aralkyl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aralkyl of to 10 carbon atoms, or an aryl or halo-, (C.sub.1 -C.sub.4) alkyl-, or (C.sub.1 -C.sub.4) alkoxy-substituted aryl aryl group of up to 10 carbon atoms; comprising(a) reacting a disulfide ester with an amine to generate a disulfide amide;(b) contacting the disulfide amide with a halogenating agent in order to cyclize the amide to form the isothiazolone.HX;(c) neutralizing the isothiazolone.

Abstract: Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.

Abstract: A process for preparing a 3-isothiazolone of the formula ##STR1## wherein Y is selected from the group consisting of alkyl or substituted alkyl of 1 to 10 carbon atoms; unsubstituted or halogen-substituted alkenyl or alkynyl of 2 to 10 carbon atoms; and aralkyl or halogen-, lower alkyl-, or lower alkoxy-substituted aralkyl of up to 10 carbon atoms;X is hydrogen or a (C.sub.1 -C.sub.2) alkyl; andX.sup.1 is hydrogen, chlorine, or a (C.sub.1 -C.sub.2) alkyl; comprising(a) reacting anhydrous ammonia with an isothiazolone salt of the formula ##STR2## wherein Z is chlorine, bromine, sulfate or fluorosulfonate;m is 1 when Z is chlorine, bromine or fluorosulfonate, and m is 2 when Z is sulfate; and(b) separating the resultant (NH.sub.4).sub.m Z from the resultant free base isothiazolone is disclosed.

Abstract: A process for obtaining pure 2-substituted-3(2H)-isothiazolones is presented, wherein the substituent is alkyl, linear or branched. By developing suitable conditions, the isothiazolone hydrochloride is isolated from the complex reaction media wherein it is formed as readily filterable crystals of high purity. Such purified crystals are then utilized in isolation of isothiazolone of high purity.

Abstract: Nitrosamine-free 3-isothiazolone biocidal compositions suitable for applications where substantial human or animal contact is anticipated, their method of use and process of preparation are disclosed.

Abstract: Disclosed novel substituted 3-isothiazolones, salts thereof, metal complexes thereof, their preparation, agricultural compositions containing them, and their utilization in the control of living organisms. In particular, novel 5-(substituted thiocarbamoyl)thio-2-substituted-4-isothiazolin-3-ones and related compounds including 5-piperidino and 5-cyano derivatives are disclosed.

Abstract: Compounds of the formula ##STR1## exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formula ##STR1## and tautomers thereof exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formula ##STR1## exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formula ##SPC1##And tautomers thereof, wherein R, R', R", Z, m and n are as defined hereinafter, exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formula ##SPC1##Which exhibit central nervous system stimulating properties and act as muscle relaxants, and intermediate compounds therefore, are disclosed.

Abstract: Compounds of the formula ##SPC1##Exhibit central nervous system stimulating properties and act as muscle relaxants. 6H-Pyrimido [1,2-c] [1,3,5]benzoxadiazepine is prepared from 1-(o-Benzophenoxymethyl)-1,2-dihydro-2-iminopyrimidine.

Abstract: Compounds of the formula ##SPC1##Exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formulae ##SPC1##Are employed in preparing compounds which exhibit central nervous system stimulating properties and act as muscle relaxants.

Abstract: Compounds of the formula ##SPC1##Exhibit central nervous system stimulating properties and act as muscle relaxants.