Patents by Inventor Ramesh Chandra Singh

Ramesh Chandra Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES
    Publication number: 20190389797
    Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 26, 2019
    Inventors: Shriprakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda, Jagdish Maganlal Patel, Daya Ram Pal, Pranav Jitendra Gangwar, Vikas Patel, Vishwadeepak Rama Pati Tripathi
  • Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
    Patent number: 10435363
    Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: October 8, 2019
    Assignee: Cadila Healthcare Limited
    Inventors: Shriprakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda, Jagdish Maganlal Patel, Daya Ram Pal, Pranav Jitendra Gangwar, Vikas Patel, Vishwadeepak Rama Pati Tripathi
  • Pyrrole compound, compositions and process for preparation thereof
    Patent number: 10385017
    Abstract: The present invention relates to compositions comprising saroglitazar magnesium wherein the saroglitazar magnesium has a purity of greater than or equal to 99% by weight, and dimer compound of Formula (IV) present in an amount relative to saroglitazar magnesium less than about 0.3% by weight by area percentage of HPLC. The present invention also related to the process for the preparation thereof and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 20, 2019
    Assignee: Cadila Healthcare Limited
    Inventors: Sanjay Jagdish Desai, Ramesh Chandra Singh, Daya Ram Pal, Dharmendra Arvindbhai Darji
  • Process for the preparation of saroglitazar pharmaceutical salts
    Patent number: 10112898
    Abstract: The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: October 30, 2018
    Assignee: Cadila Healthcare Limited
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Jagdish Maganlal Patel, Vikas Patel, Vishwadeepak Rama Pati Tripathi, Pranav Jitendra Gangwar, Jigar Mukundbhai Raval
  • POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF
    Publication number: 20180297946
    Abstract: The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. The present invention also provides pharmaceutical composition comprising an amorphous form saroglitazar magnesium.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 18, 2018
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Vikas Patel, Amar Rajendra Desai
  • POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF
    Publication number: 20180297945
    Abstract: The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. The present invention also provides pharmaceutical composition comprising an amorphous form saroglitazar magnesium.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 18, 2018
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Vikas Patel, Amar Rajendra Desai
  • PYRROLE COMPOUND, COMPOSITIONS AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20180265466
    Abstract: The present invention relates to compositions comprising saroglitazar magnesium wherein the saroglitazar magnesium has a purity of greater than or equal to 99% by weight, and dimer compound of Formula (IV) present in an amount relative to saroglitazar magnesium less than about 0.3% by weight by area percentage of HPLC. The present invention also related to the process for the preparation thereof and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: October 13, 2016
    Publication date: September 20, 2018
    Applicant: Cadila Healthcare Ltd.
    Inventors: Sanjay Jagdish Desai, Ramesh Chandra Singh, Daya Ram Pal, Dharmendra Arvindbhai Darji
  • Polymorphic form of pyrrole derivative and intermediate thereof
    Patent number: 9951009
    Abstract: The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. The present invention also provides pharmaceutical composition comprising an amorphous form saroglitazar magnesium.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: April 24, 2018
    Assignee: Cadila Healthcare Limited
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Vikas Patel, Amar Rajendra Desai
  • Amorphous form of vilazodone hydrochloride and process for its preparation
    Patent number: 9708300
    Abstract: The present invention relates to an amorphous form of vilazodone hydrochloride and process for the preparation of amorphous form of vilazodone hydrochloride. The invention also relates to pharmaceutical compositions that include a therapeutically effective amount of the amorphous form of vilazodone hydrochloride and use of said compositions for the treatment of major depressive disorder (MDD).
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: July 18, 2017
    Assignee: Cadila Healthcare Limited
    Inventors: Shirprakash Dhar Dwivedi, Ramesh Chandra Singh, Jigar Mukundbhai Raval
  • PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES
    Publication number: 20170144968
    Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
    Type: Application
    Filed: December 1, 2016
    Publication date: May 25, 2017
    Inventors: Shriprakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda, Jagdish Maganlal Patel, Daya Ram Pal, Pranav Jitendra Gangwar, Vikas Patel, Vishwadeepak Rama Pati Tripathi
  • Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its intermediates
    Patent number: 9409899
    Abstract: The present invention discloses process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclohexylmethanisoindol-1,3-dione and intermediates thereof.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: August 9, 2016
    Assignee: Cadila Healthcare Limited
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda
  • POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF
    Publication number: 20160207884
    Abstract: The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. The present invention also provides pharmaceutical composition comprising an amorphous form saroglitazar magnesium.
    Type: Application
    Filed: August 28, 2014
    Publication date: July 21, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shri Prakash Dhar DWIVEDI, Ramesh Chandra SINGH, Vikas PATEL, Amar Rajendra DESAI
  • IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES
    Publication number: 20160194280
    Abstract: The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shri Prakash Dhar DWIVEDI, Ramesh Chandra SINGH, Jagdish Maganlal PATEL, Vikas PATEL, Vishwadeepak Rama Pati TRIPATHI, Pranav Jitendra GANGWAR, Jigar Mukundbhai RAVAL
  • A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES
    Publication number: 20160107989
    Abstract: The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.
    Type: Application
    Filed: May 30, 2014
    Publication date: April 21, 2016
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shriprakash Dhar DWIVEDI, Ramesh Chandra SINGH, Rajendra Gokalbhai CHAVDA, Jagdish Maganlal PATEL, Daya Ram PAL, Jigar Mukundhai RAVAL, Mukul Hariprasad SHARMA, Pranav Jitendra GANGWAR, Sachin Ashokrao PATIL, Vikas PATEL, Vishwadeepak Rama Patil TRIPATHI
  • Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
    Patent number: 9212166
    Abstract: The present invention provides crystalline form of intermediates of Formula 2A, The present invention also provides process for the preparation of dabigatran etexilate mesylate; polymorph of intermediates thereof; particularly processes for the preparation of crystalline form of intermediates. The present invention also relates to the use of crystalline intermediates for the preparation of dabigatran etexilate mesylate.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: December 15, 2015
    Assignee: Cadila Healthcare Limited
    Inventors: Shriprakash Dhar Dwivedi, Ramesh Chandra Singh, Jigar Mukundbhai Raval
  • PROCESS FOR PREPARING BENZISOTHIAZOL-3-YL-PIPERAZIN-1-YL-METHYL-CYCLO HEXYLMETHANISOINDOL-1,3-DIONE AND ITS INTERMEDIATES
    Publication number: 20150018368
    Abstract: The present invention discloses process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexyl-methan-isoindol-1,3-dione and intermediates thereof.
    Type: Application
    Filed: February 12, 2013
    Publication date: January 15, 2015
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda
  • PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF
    Publication number: 20150011589
    Abstract: The present invention provides crystalline form of intermediates of Formula 2A, The present invention also provides process for the preparation of dabigatran etexilate mesylate; polymorph of intermediates thereof; particularly processes for the preparation of crystalline form of intermediates. The present invention also relates to the use of crystalline intermediates for the preparation of dabigatran etexilate mesylate.
    Type: Application
    Filed: January 21, 2013
    Publication date: January 8, 2015
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shriprakash Dhar Dwivedi, Ramesh Chandra Singh, Jigar Mukundbhai Raval
  • POLYMORPHIC FORM OF 5-(4-[4-(5-CYANO-1H-INDOL-3-YL) BUTYL] PIPERAZIN-1-YL) BENZOFURAN-2-CARBOXAMIDE AND PROCESS FOR PREPARING THEREOF
    Publication number: 20140179713
    Abstract: The present invention provides a solid state Form-Z of 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide. The present invention also provides a process for preparing Form-Z of 5-(4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide comprising the steps of i) reacting solid state form of 5-(1-piperazinyl)benzofuran-2-carboxamide or its salts with 3-(4-chlorobutyl)-1H-indole-5-carbonitrile an organic solvent in presence of a base to obtain crude vilazodone free base; ii) purifying the crude vilazodone free base of step (i) in an organic solvent; iii) treating the purified vilazodone free base of step (ii) with an organic solvent to obtain solid state form-Z of vilazodone. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of an amorphous form of vilazodone hydrochloride and use of solid state Form-Z of vilazodone for the treatment of major depressive disorders.
    Type: Application
    Filed: November 5, 2013
    Publication date: June 26, 2014
    Inventors: Shriprakash Dhar DWIVEDI, Ramesh Chandra Singh, Sachin Ashokrao Patil
  • AMORPHOUS FORM OF VILAZODONE HYDROCHLORIDE AND PROCESS FOR ITS PREPARATION
    Publication number: 20140057925
    Abstract: The present invention relates to an amorphous form of vilazodone hydrochloride and process for the preparation of amorphous form of vilazodone hydrochloride. The invention also relates to pharmaceutical compositions that include a therapeutically effective amount of the amorphous form of vilazodone hydrochloride and use of said compositions for the treatment of major depressive disorder (MDD).
    Type: Application
    Filed: March 16, 2012
    Publication date: February 27, 2014
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Shriprakash Dhar Dwived, Ramesh Chandra Singh, Jigar Mukundbhai Raval