Patents by Inventor Ramesh Gujjar

Ramesh Gujjar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
    Patent number: 9238653
    Abstract: Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: January 19, 2016
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, MMV MEDICINES FOR MALARIA VENTURE, UNIVERSITY OF WASHINGTON
    Inventors: Pradipsinh K. Rathod, David Floyd, Jeremy Burrows, Alka Marwaha, Ramesh Gujjar, Jose Coteron-Lopez, Margaret Phillips, Susan A. Charman, David Matthews
  • Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
    Patent number: 9216983
    Abstract: Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII: where R1 through R33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: December 22, 2015
    Assignees: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM, UNIVERSITY OF WASHINGTON, MONASH UNIVERSITY
    Inventors: Margaret Phillips, Pradipsinh K. Rathod, Ramesh Gujjar, Alka Marwaha, Susan A. Charman
  • ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE
    Publication number: 20120302586
    Abstract: Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
    Type: Application
    Filed: September 28, 2010
    Publication date: November 29, 2012
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, MONASH UNIVERSITY, CLAYTON, GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO, S.L, UNIVERSITY OF WASHINGTON, MEDICINES FOR MALARIA VENTURE
    Inventors: Pradipsinh K. Rathod, David Floyd, Jeremy Burrows, Alka Marwaha, Ramesh Gujjar, Jose Coteron-Lopez, Margaret Phillips, Susan A. Charman, David Matthews
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY
    Publication number: 20090209557
    Abstract: Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII: where R1 through R33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.
    Type: Application
    Filed: December 19, 2008
    Publication date: August 20, 2009
    Inventors: Margaret PHILLIPS, Pradipsinh K. Rathod, Ramesh Gujjar, Alka Marwaha, Susan A. Charman
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY
    Publication number: 20080027079
    Abstract: Pharmaceutical compositions comprising compounds of the formula where R1, R2, and R3 are described here, have therapeutic utility in selectively inhibiting P. falciparum dihydroorotate dehydrogenase. Accordingly, such compositions have use in the treatment and prevention of malaria.
    Type: Application
    Filed: June 5, 2007
    Publication date: January 31, 2008
    Inventors: Margaret Phillips, Pradipsinh Rathod, Jeffery Baldwin, Ramesh Gujjar
  • C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Patent number: 7056913
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 6, 2006
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Kumar Pogula
  • C8 - linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Publication number: 20050222132
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Pogula
  • Pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids useful as anti-cancer agents
    Patent number: 6800622
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, anticancer (antitumour) activity.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: October 5, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • PYRENE-LINKED PYRROLO[2,1--C][1,4]BENZODIAZEPINE HYBRIDS USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20040192677
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1 -c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1 -c][1,4]benzodiazepin-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, aticancer (antitumour) activity.
    Type: Application
    Filed: March 25, 2003
    Publication date: September 30, 2004
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • Process for the preparation of antitumor agents
    Patent number: 6362331
    Abstract: The present invention provides a process for the preparation of a novel pyrrolo[2,1-c][1,4]benzodiazepine of formula VI wherein R is H, OII, OAc and R1 is H, and n is 3 to 5, by reacting (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzyl]-pyrrolidine-2-carboxy-carbaldehyde diethyl thioacetal with a dibromoalkane, isolating (2S)-N-[4-(3-bromoalkoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxy carbaldehyde diethyl thioacetal so formed and reacting the isolate with a dilactam, isolating 8-{[(2S)-N-5-methoxy-2-nitrobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal}-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11 dione, reducing the above nitro compound, isolating the 8-{[(2S)-N-5-methoxy-2-aminobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal]-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione, reacting the ami
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: March 26, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Chakravarthy Laxman Nallan, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu