Abstract: Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal.

Abstract: A multifunctional personal safety device includes a main body having an ergonomic gripping surface, and a finger trigger for selectively activating a non-contact deterrent unit and an active deterrent unit. The non-contact deterrent unit including a controller, memory, wireless communication unit, a siren, a light, a laser, and a camera. The information captured by the camera is stored in one or both of a removable media card and the onboard memory. The active deterrent unit includes an aerosol canister containing one or both of a chemical irritant or an inflammatory agent. A safety switch transitions between a locked and unlocked position wherein the finger trigger is selectively blocked and allowed to engage the aerosol canister, respectively.

Abstract: A multifunctional personal safety device includes a main body having an ergonomic gripping surface, and a finger trigger for selectively activating a non-contact deterrent unit and an active deterrent unit. The non-contact deterrent unit including a controller, memory, wireless communication unit, a siren, a light, a laser, and a camera. The information captured by the camera is stored in one or both of a removable media card and the onboard memory. The active deterrent unit includes an aerosol canister containing one or both of a chemical irritant or an inflammatory agent. A safety switch transitions between a locked and unlocked position wherein the finger trigger is selectively blocked and allowed to engage the aerosol canister, respectively.

Abstract: Systems and methods are provided for separating oxygen from air using a sorption/desorption cycle that includes a reduced or minimized difference between the maximum and minimum pressures involved in the sorption/desorption cycle. The reduced or minimized difference in pressures can be achieved in part by using valves that can allow for commercial scale flow rates while avoiding large pressure drops for flows passing through the valves. A rotary wheel adsorbent is an example of a system that can allow for a sorption/desorption cycle with reduced and/or minimized pressure drops across valves associated with the process. Stationary adsorbent beds can also be used in combination with commercially available valves that have reduced and/or minimized pressure drops.

Abstract: A method for isolation of exosomes from bovine colostrum powder or goat colostrum powder, and the use of the isolated exosomes as nano carriers for small drug molecules, is described. Exosomes isolated from bovine colostrum powder averaged <85 nm in size, carried the surface-bound protein markers, Alix, TSG101, CD63 and CD81, and accepted various lipophilic (curcumin, withaferin A, paclitaxel) and hydrophilic (anthocyanidins) agents to serve as a nano carrier.

Abstract: A heat transfer fluid can be used as part of a multi-phase adsorption environment to allow for improved separations of gas components using a solid adsorbent. The heat transfer fluid can reduce or minimize the temperature increase of the solid adsorbent that occurs during an adsorption cycle. Reducing or minimizing such a temperature increase can enhance the working capacity for an adsorbent and/or enable the use of adsorbents that are not practical for commercial scale adsorption using conventional adsorption methods. The multi-phase adsorption environment can correspond to a trickle bed environment, a slurry environment, or another convenient environment where at least a partial liquid phase of a heat transfer fluid is present during gas adsorption by a solid adsorbent.

Abstract: Systems and methods are described for providing cloud-based virtual local networks. A computerized method for providing cloud-based virtual local networks includes receiving at a network gateway a request for a network address from a network switch, communicating with a user device management entity (uDME) server to authorize the network switch, receiving an authorization response from the uDME server for the network switch, receiving a network address pool at the network gateway from the uDME server, and creating at the network gateway a virtual home router containing a virtual home router context that is unique to the virtual home router and associated with the network address pool.

Abstract: Systems and methods are provided for separating oxygen from air using a sorption/desorption cycle that includes a reduced or minimized difference between the maximum and minimum pressures involved in the sorption/desorption cycle. The reduced or minimized difference in pressures can be achieved in part by using valves that can allow for commercial scale flow rates while avoiding large pressure drops for flows passing through the valves. A rotary wheel adsorbent is an example of a system that can allow for a sorption/desorption cycle with reduced and/or minimized pressure drops across valves associated with the process. Stationary adsorbent beds can also be used in combination with commercially available valves that have reduced and/or minimized pressure drops.

Abstract: A dipole-magnet system and method for producing high-magnetic-fields, including an open-region located in a radially-central-region to allow particle-beam transport and other uses, low-temperature-superconducting-coils comprised of low-temperature-superconducting-wire located in radially-outward-regions to generate high magnetic-fields, high-temperature-superconducting-coils comprised of high-temperature-superconducting-tape located in radially-inward-regions to generate even higher magnetic-fields and to reduce erroneous fields, support-structures to support the coils against large Lorentz-forces, a liquid-helium-system to cool the coils, and electrical-contacts to allow electric-current into and out of the coils. The high-temperature-superconducting-tape may be comprised of bismuth-strontium-calcium-copper-oxide or rare-earth-metal, barium-copper-oxide (ReBCO) where the rare-earth-metal may be yttrium, samarium, neodymium, or gadolinium.

Abstract: Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal.

Abstract: Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal.

Abstract: A heat transfer fluid can be used as part of a multi-phase adsorption environment to allow for improved separations of gas components using a solid adsorbent. The heat transfer fluid can reduce or minimize the temperature increase of the solid adsorbent that occurs during an adsorption cycle. Reducing or minimizing such a temperature increase can enhance the working capacity for an adsorbent and/or enable the use of adsorbents that are not practical for commercial scale adsorption using conventional adsorption methods. The multi-phase adsorption environment can correspond to a trickle bed environment, a slurry environment, or another convenient environment where at least a partial liquid phase of a heat transfer fluid is present during gas adsorption by a solid adsorbent.

Abstract: Systems and methods are provided for combined cycle power generation while reducing or mitigating emissions during power generation. Recycled exhaust gas from a power generation combustion reaction can be separated using a swing adsorption process so as to generate a high purity CO2 stream while reducing/minimizing the energy required for the separation and without having to reduce the temperature of the exhaust gas. This can allow for improved energy recovery while also generating high purity streams of carbon dioxide and nitrogen.

Abstract: Systems and methods are provided for combined cycle power generation while reducing or mitigating emissions during power generation. Recycled exhaust gas from a power generation combustion reaction can be separated using a swing adsorption process so as to generate a high purity CO2 stream while reducing/minimizing the energy required for the separation and without having to reduce the temperature of the exhaust gas. This can allow for improved energy recovery while also generating high purity streams of carbon dioxide and nitrogen.

Abstract: A dipole-magnet system and method for producing high-magnetic-fields, including an open-region located in a radially-central-region to allow particle-beam transport and other uses, low-temperature-superconducting-coils comprised of low-temperature-superconducting-wire located in radially-outward-regions to generate high magnetic-fields, high-temperature-superconducting-coils comprised of high-temperature-superconducting-tape located in radially-inward-regions to generate even higher magnetic-fields and to reduce erroneous fields, support-structures to support the coils against large Lorentz-forces, a liquid-helium-system to cool the coils, and electrical-contacts to allow electric-current into and out of the coils. The high-temperature-superconducting-tape may be comprised of bismuth-strontium-calcium-copper-oxide or rare-earth-metal, barium-copper-oxide (ReBCO) where the rare-earth-metal may be yttrium, samarium, neodymium, or gadolinium.

Abstract: Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal.

Abstract: Embodiments described herein generally relate to creating an autonomous role-based security system for a database management system, wherein a super user may not always be required. A computer-implemented method is described. The method includes establishing one or more privileges in a database system, each privilege controlling access to an administrative function for the database system. Each privilege is assigned to one or more roles. Each role may always have a minimum set of users with only administrative rights over the role. A request is received from a first user to grant a role to a second user. A database management system determines whether the first user has administrative privileges over the role. If the first user has administrative privileges over the role, the role is granted to the second user. The database system may satisfy the principles of least privilege and separation of duties.

Abstract: A computing system for processing network traffic includes a plurality of network ports configured to receive network traffic, a plurality of processing blades, not directly coupled with the plurality of network ports, configured to process the network traffic, a switch coupled with the plurality of processing blades and configured to support inter-blade communications among the plurality of processing blades, a router coupled with the switch and the plurality of network ports, the router configured to forward the network traffic to one or more of the plurality of processing blades based on resource information of the plurality of the processing blades, and a system controller coupled to the router and the plurality of processing blades, the system controller configured to receive and maintain the resource information from the plurality of the processing blades and further configured to update the router with the resource information of the plurality of the processing blades.

Abstract: A computing system for processing network traffic includes a plurality of network ports configured to receive network traffic, a plurality of processing blades, not directly coupled with the plurality of network ports, configured to process the network traffic, a switch coupled with the plurality of processing blades and configured to support inter-blade communications among the plurality of processing blades, a router coupled with the switch and the plurality of network ports, the router configured to forward the network traffic to one or more of the plurality of processing blades based on resource information of the plurality of the processing blades, and a system controller coupled to the router and the plurality of processing blades, the system controller configured to receive and maintain the resource information from the plurality of the processing blades and further configured to update the router with the resource information of the plurality of the processing blades.

Abstract: Methods for organic compound conversion are disclosed. Particular methods include providing a first mixture comprising ?10.0 wt % of at least one oxygenate, based on the weight of the first mixture; contacting said first mixture in at least a first moving bed reactor with a catalyst under conditions effective to covert at least a portion of the first mixture to a product stream comprising water, hydrogen, and one or more hydrocarbons; and separating from said product stream (i) at least one light stream and ii) at least one heavy stream, wherein the method is characterized by a recycle ratio of ?5.0.