Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.

Abstract: A variable pitch fan for a helicopter equipped with a NOTAR.RTM. mechanical antitorque directional control system comprises a plurality of blade assemblies. Each blade assembly includes a blade portion, which is molded from a blended material which includes fiber reinforced polypropylene. A key to the invention is the use of long fibers, having a length of at least approximately one-half inch, for reinforcement, the long fibers providing for about twice the pull-out strength of short or chopped fibers. Another key aspect of the invention is the use of a blowing agent in the blended material, which serves to reduce weight and warpage by creating a foamed structure having a variable density, the structure retaining considerable strength because of the fiber reinforcement. The blade portion is molded about a spar which has holes therethrough, the holes providing a mechanical interlock between the blade and the spar.

Abstract: A variable pitch fan for a helicopter equipped with a NOTAR.TM. mechanical antitorque directional control system comprises a plurality of blade assemblies. Each blade assembly includes a blade portion, which is molded from a blended material which includes fiber reinforced polypropylene. A key to the invention is the use of long fibers, having a length of at least approximately one-half inch, for reinforcement, the long fibers providing for about twice the pull-out strength of short or chopped fibers. Another key aspect of the invention is the use of a blowing agent in the blended material, which serves to reduce weight and warpage by creating a foamed structure having a variable density, the structure retaining considerable strength because of the fiber reinforcement. The blade portion is molded about a spar which has holes therethrough, the holes providing a mechanical interlock between the blade and the spar.