Patents by Inventor Ramesh Kakarla

Ramesh Kakarla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME
    Publication number: 20230143612
    Abstract: The present invention includes substituted 1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 11, 2023
    Inventors: Vijay Ahuja, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Ramesh Kakarla, Sharon Marie Kirk, Duyan Nguyen, Seyma Ozturk, Jorge G. Quintero, Michael J. Sofia
  • SUBSTITUTED ISOINDOLONYL 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
    Publication number: 20230019280
    Abstract: The present disclosure includes substituted isoindolinyl 2,2?-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 19, 2023
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Jorge Quintero, Michael J. Sofia
  • SUBSTITUTED POLYCYCLIC CARBOXYLIC ACIDS, ANALOGUES THEREOF, AND METHODS USING SAME
    Publication number: 20220125771
    Abstract: The present invention includes substituted polycyclic carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.
    Type: Application
    Filed: January 15, 2020
    Publication date: April 28, 2022
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Sharon Marie Kirk, Jorge Quintero, Michael J. Sofia
  • Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
    Patent number: 11098010
    Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 24, 2021
    Assignee: Arbutus Biopharma Corporation
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Ramesh Kakarla, Steven Kultgen, Jorge Quintero
  • SUBSTITUTED 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
    Publication number: 20210251991
    Abstract: The present disclosure includes substituted 2,2?-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.
    Type: Application
    Filed: May 14, 2019
    Publication date: August 19, 2021
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Jorge Quintero, Michael J. Sofia
  • Substituted pyridinone-containing trycyclic compounds, and methods using same
    Patent number: 11013726
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: May 25, 2021
    Assignee: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • Substituted pyridinone-containing trycyclic compounds, and methods using same
    Patent number: 10821103
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: November 3, 2020
    Assignee: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME
    Publication number: 20200261432
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 20, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • Substituted 1-hydroxy-pyridin-2(1H)-ones, and methods of making and using same
    Patent number: 10550084
    Abstract: The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 4, 2020
    Assignee: Arbutus Biopharma Corporation
    Inventors: Ramesh Kakarla, Bruce D. Dorsey
  • SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME
    Publication number: 20200024226
    Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.
    Type: Application
    Filed: March 20, 2018
    Publication date: January 23, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Ramesh Kakarla, Steven Kultgen, Jorge Quintero
  • SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME
    Publication number: 20190314347
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: November 3, 2017
    Publication date: October 17, 2019
    Inventors: Danielle Lauren BAILEY, Yingzhi BI, Shuai CHEN, Bruce D. DORSEY, Dimitar B. GOTCHEV, Richard James HOLLAND, Ramesh KAKARLA, Duyan NGUYEN, Mark Christopher WOOD
  • Substituted 2-N-hydroxy-1,3-dioxo-1,2,3,4-tetrahydronaphthyridines, and methods of making and using same
    Patent number: 10358447
    Abstract: The present invention includes novel substituted 2-N-hydroxy-1,3-dioxo-1,2,3,4-tetrahydronaphthyridines, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: July 23, 2019
    Assignee: Arbutus Biopharma Corporation
    Inventors: Ramesh Kakarla, Bruce D. Dorsey
  • SUBSTITUTED 1-HYDROXY-PYRIDIN-2(1H)-ONES, AND METHODS OF MAKING AND USING SAME
    Publication number: 20190169128
    Abstract: The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Inventors: RAMESH KAKARLA, BRUCE D. DORSEY
  • Indole derivatives and methods for antiviral treatment
    Patent number: 8735414
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: May 27, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Malcolm MacCoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Hepatitis C virus inhibitors
    Patent number: 8735398
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: May 27, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Omar D. Lopez, Denis R. St. Laurent, Jason Goodrich, Jeffrey Lee Romine, Michael Serrano-Wu, Fukang Yang, Ramesh Kakarla, Xuejie Yang, Yuping Qiu, Lawrence B. Snyder
  • Hepatitis C virus inhibitors
    Patent number: 8362020
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: January 29, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: Omar D. Lopez, Denis R. St. Laurent, Jason Goodrich, Jeffrey Lee Romine, Michael Serrano-Wu, Fukang Yang, Ramesh Kakarla, Xuejie Yang, Yuping Qiu, Lawrence B. Snyder
  • COMPOUNDS
    Publication number: 20120202794
    Abstract: Disclosed herein are compounds useful for treating a viral infection, such as HCV.
    Type: Application
    Filed: January 19, 2012
    Publication date: August 9, 2012
    Applicant: PHARMASSET, INC.
    Inventors: MICHAEL JOSEPH SOFIA, RAMESH KAKARLA, JIAN LIU, DEVAN NADUTHAMBI, RALPH MOSLEY, HOLLY MICOLOCHICK STEUER
  • INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT
    Publication number: 20120184574
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 19, 2012
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Malcolm Maccoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W. Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Inhibitors of HCV replication
    Patent number: 8143288
    Abstract: Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: March 27, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Serrano-Wu, Makonen Belema, Lawrence B. Snyder, Nicholas A. Meanwell, Denis R. St. Laurent, Ramesh Kakarla, Van N. Nguyen, Yuping Qiu, Xuejie Yang, John E. Leet, Min Gao, Donald R. O'Boyle, II, Julie A. Lemm, Fukang Yang
  • Hepatitis C Virus Inhibitors
    Publication number: 20110294819
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 1, 2011
    Inventors: Omar D. Lopez, Denis R. St. Laurent, Jason Goodrich, Jeffrey Lee Romine, Michael Serrano-Wu, Fukang Yang, Ramesh Kakarla, Xuejie Yang, Yuping Qiu, Lawrence B. Snyder