Patents by Inventor Ramesh M. Kanojia

Ramesh M. Kanojia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
    Patent number: 7329654
    Abstract: The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: February 12, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ramesh M. Kanojia, Nareshkumar F. Jain, Raymond Ng, Zhihua Sui, Jiayi Xu
  • Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
    Patent number: 7105679
    Abstract: The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: September 12, 2006
    Inventors: Ramesh M. Kanojia, Nareshkumar F. Jain, Raymond Ng, Zhihua Sui, Jiayi Xu
  • Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
    Publication number: 20040259915
    Abstract: The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Application
    Filed: November 21, 2003
    Publication date: December 23, 2004
    Inventors: Ramesh M. Kanojia, Nareshkumar F. Jain, Raymond Ng, Zhihua Sui, Jiayi Xu
  • Neurotrophic pyrrolidines and piperidines, and related compositions and methods
    Patent number: 6809107
    Abstract: This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: October 26, 2004
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ramesh M. Kanojia, Alfonzo D. Jordan, Allen B. Reitz, Mark J. Macielag, Boyu Zhao
  • Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
    Publication number: 20030216463
    Abstract: The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
    Type: Application
    Filed: December 2, 2002
    Publication date: November 20, 2003
    Inventors: Ramesh M. Kanojia, Nareshkumar F. Jain, Raymond Ng, Zhihua Sui, Jiayi Xu
  • Triphenylalkyl antimicrobial agents
    Patent number: 5874436
    Abstract: The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: February 23, 1999
    Inventors: James P. Demers, Sigmond Johnson, Michele Ann Weidner-Wells, Ramesh M. Kanojia, Stephanie A. Fraga, Dieter Klaubert
  • Diaryl antimicrobial agents
    Patent number: 5773469
    Abstract: The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: June 30, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, James P. Demers, Dennis J. Hlasta, Sigmond G. Johnson, Dieter H. Klaubert
  • Triphenylalkyl antimicrobial agents
    Patent number: 5643950
    Abstract: The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: James P. Demers, Sigmond Johnson, Michele Ann Weidner-Wells, Ramesh M. Kanojia, Stephanie A. Fraga, Dieter Klaubert
  • Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
    Patent number: 5215987
    Abstract: Substituted benzhydryl 2-hydroxypropyl piperazine derivatives and methods of synthesis of the derivatives are described. The substituted benzhydryl 2-hydroxypropyl piperazine derivatives are useful as cardiotonic agents.
    Type: Grant
    Filed: April 23, 1990
    Date of Patent: June 1, 1993
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Ramesh M. Kanojia, Jeffrey B. Press
  • 6-substituted purinyl piperazine derivatives
    Patent number: 5164390
    Abstract: 6-substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: November 17, 1992
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Ramesh M. Kanojia, Jeffery B. Press
  • 6-substituted purinyl piperazine derivatives
    Patent number: 5021574
    Abstract: 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: June 4, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Ramesh M. Kanojia, Jeffery B. Press
  • O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
    Patent number: 4880817
    Abstract: O-functional derivatives of substituted isoquinolin-3-ol compounds of the general formula ##STR1## that exhibit cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using the compounds are described.
    Type: Grant
    Filed: June 9, 1987
    Date of Patent: November 14, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, O. William Lever, Jr., Jeffery B. Press
  • 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents
    Patent number: 4876257
    Abstract: 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: October 24, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Ramesh M. Kanojia, Jeffery B. Press
  • Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
    Patent number: 4822800
    Abstract: Substituted 3-isoquinolinol compounds of the general formula ##STR1## that exhibit cardiotonic, renal vasodilating and phosphodiesterase fraction III properties are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using those compounds are described.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: April 18, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Robert Falotico, Ramesh M. Kanojia, Jeffery B. Press, Alfonso J. Tobia
  • Thienopyridines useful as cardiovascular agents
    Patent number: 4775757
    Abstract: The synthesis of thienopyridine derivatives is described. The novel thienopyridine derivatives are cardiotonic agents and renal vasodilating agents. The compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: October 4, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, James J. McNally, Jeffery B. Press
  • 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
    Patent number: 4714705
    Abstract: Substituted 3-isoquinolinol compounds of the general formula ##STR1## that exhibit cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using those compounds are described.
    Type: Grant
    Filed: July 7, 1986
    Date of Patent: December 22, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Robert Falotico, Alfonso J. Tobia, Jeffery B. Press
  • 3,4-Dialkoxy-2-alkylcarbonyl analino compounds
    Patent number: 4556739
    Abstract: A process for preparing 4-alkyl-2(1H)quinazolinone-1-alkanoic acid derivatives is described. The 4-alkyl-2(1H)quinazolinones are useful as cardiovascular agents.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: December 3, 1985
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Victor T. Bandurco, Seymour D. Levine, Dennis M. Mulvey, Alfonso J. Tobia
  • Substituted 4-alkyl-2-(1H) quinazolinone-1-alkanoic acid derivatives
    Patent number: 4555570
    Abstract: A process for preparing 4-alkyl-2-(1H) quinazolinone-1-alkanoic acid derivatives is described. The 4-alkyl-2-(1H) quinazolinones are useful as cardiovascular agents.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: November 26, 1985
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Victor T. Bandurco, Seymour D. Levine, Dennis M. Mulvey, Alfonso J. Tobia
  • Oxepanes and processes therefor
    Patent number: 4479964
    Abstract: Chemical compounds having a substituted oxepane ring and methods of preparing such compounds are described. The compounds are active as utero-evacuant agents.
    Type: Grant
    Filed: April 24, 1981
    Date of Patent: October 30, 1984
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Michael P. Wachter, Robert H. K. Chen
  • Chemical compounds and processes
    Patent number: 4408060
    Abstract: Chemical compounds having a substituted oxepane ring and methods of preparing such compounds are described. The compounds are active as utero-evacuant agents.
    Type: Grant
    Filed: January 12, 1981
    Date of Patent: October 4, 1983
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ramesh M. Kanojia, Michael P. Wachter, Robert H. K. Chen