Patents by Inventor Ramesh R. Bhatt

Ramesh R. Bhatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIGEN BINDING MOLECULES TO TIGIT
    Publication number: 20200339678
    Abstract: Provided herein are antigen binding molecules that bind to TIGIT, including antibodies and antigen binding fragments thereof.
    Type: Application
    Filed: July 10, 2020
    Publication date: October 29, 2020
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Ramesh R. Bhatt, Todd Kinsella, Wei Li
  • Antigen binding molecules to TIGIT
    Patent number: 10759855
    Abstract: Provided herein are antigen binding molecules that bind to TIGIT, include antibodies and antigen binding fragments thereof.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: September 1, 2020
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ramesh R. Bhatt, Todd Kinsella, Wei Li
  • Sur-binding proteins against ERBB3
    Patent number: 10300140
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: May 28, 2019
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
  • CONJUGATES OF SURROGATE LIGHT CHAIN CONSTRUCTS
    Publication number: 20190127482
    Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.
    Type: Application
    Filed: October 12, 2018
    Publication date: May 2, 2019
    Inventors: Lawrence C. HOROWITZ, Ramesh R. BHATT, Charles H. HANNUM, Pamela K. FOREMAN, Danying CAI, Medini GORE, Li XU, Phil KOBEL
  • ANTIGEN BINDING MOLECULES TO TIGIT
    Publication number: 20180155422
    Abstract: Provided herein are antigen binding molecules that bind to TIGIT, include antibodies and antigen binding fragments thereof.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Inventors: Ramesh R. Bhatt, Todd Kinsella, Wei Li
  • Surrogate binding proteins which bind DR4 and/or DR5
    Patent number: 9975956
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 22, 2018
    Assignee: i2 PHARMACEUTICALS, INC.
    Inventors: Arun K. Kashyap, Ramesh R. Bhatt, Michael Horowitz, Lawrence Horowitz, Sihong Zhou, Ryann E. O'Neil, Charles H. Hannum, Aaron L. Kurtzman, Li Xu
  • BINDING MOLECULE CONJUGATES
    Publication number: 20160354486
    Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.
    Type: Application
    Filed: December 22, 2015
    Publication date: December 8, 2016
    Inventors: Lawrence C. Horowitz, Ramesh R. Bhatt, Charles H. Hannum, Pamela K. Foreman, Danying Cai, Medini Gore, Li Xu, Phil Kobel
  • Expression of surrogate light chains
    Patent number: 8969082
    Abstract: The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 3, 2015
    Assignee: Sea Lane Biotechnologies, LLC
    Inventors: Lawrence Horowitz, Ramesh R. Bhatt
  • MULTISPECIFIC STACKED VARIABLE DOMAIN BINDING PROTEINS
    Publication number: 20150045540
    Abstract: The present invention concerns multi-specific stacked variable domain binding proteins.
    Type: Application
    Filed: June 28, 2012
    Publication date: February 12, 2015
    Inventors: Lawrence C. Howowitz, Ramesh R. Bhatt, Li Xu, Arun K. Kashyap, Sandra M. Wang, Pamela Foreman, Medini Gore, Phil Kobel, Danying Cai
  • BINDING MOLECULE CONJUGATES
    Publication number: 20150011736
    Abstract: The present invention concerns methods for identifying, producing, and engineering binding molecule conjugates, and to the conjugates produced. In particular, the invention concerns Surrobody conjugates composed of an antibody heavy chain variable domain and a surrogate light chain, wherein the surrogate light chain and/or the antibody heavy chain variable domain is conjugated to a therapeutic or diagnostic agent.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 8, 2015
    Inventors: Lawrence C. Horowitz, Ramesh R. Bhatt, Charles H. Hannum, Pamela K. Foreman, Danying Cai, Medini Gore, Li Xu, Phil Kobel
  • SURROGATE BINDING PROTEINS
    Publication number: 20150004162
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 1, 2015
    Inventors: Arun K. Kashyap, Ramesh R. Bhatt, Michael Horowitz, Lawrence Horowitz, Sihong Zhou, Ryann E. O'Neil, Charles H. Hannum, Aaron L. Kurtzman, Li Xu
  • SUR-BINDING PROTEINS
    Publication number: 20140308287
    Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.
    Type: Application
    Filed: July 27, 2012
    Publication date: October 16, 2014
    Applicant: Sea Lane Biotechnologies, LLC
    Inventors: Ramesh R. Bhatt, Pamela K. Foreman, Lawrence C. Horowitz, Michael Horowitz, Medini Gore, Phil Kobel
  • INFLUENZA NEUTRALIZING AGENTS
    Publication number: 20140199682
    Abstract: The present invention concerns methods and means for identifying, producing, and engineering neutralizing agents against influenza A viruses, and to the neutralizing agents produced. In particular, the invention concerns neutralizing agents against various influenza A virus subtypes, and methods and means for making such agents.
    Type: Application
    Filed: November 17, 2011
    Publication date: July 17, 2014
    Applicant: SEA LANE BIOTECHNOLOGIES, LLC
    Inventors: Lawrence Horowitz, Ramesh R. Bhatt, Arun K. Kashyap
  • Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening
    Patent number: 8716195
    Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: May 6, 2014
    Assignee: Bioren, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Takeuchi Toshihilo, Randy Shen, Ramesh R. Bhatt, Nurten Beyaz-Kavuncu
  • COMBINATORIAL LIBRARIES OF CONFORMATIONALLY CONSTRAINED POLYPEPTIDE SEQUENCES
    Publication number: 20130288900
    Abstract: The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses.
    Type: Application
    Filed: November 11, 2011
    Publication date: October 31, 2013
    Inventors: Lawrence Horowitz, Ramesh R. Bhatt, Aaron L. Kurtzman
  • EXPRESSION OF SURROGATE LIGHT CHAINS
    Publication number: 20100330676
    Abstract: The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.
    Type: Application
    Filed: June 25, 2010
    Publication date: December 30, 2010
    Inventors: Lawrence Horowitz, Ramesh R. Bhatt
  • CONSTRUCTS AND LIBRARIES COMPRISING ANTIBODY SURROGATE KAPPA LIGHT CHAIN SEQUENCES
    Publication number: 20100062950
    Abstract: The present invention concerns constructs and libraries comprising antibody surrogate ? light chain sequences. In particular, the invention concerns constructs comprising antibody surrogate ? light chain sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy and/or light chain domain sequences, and libraries containing the same.
    Type: Application
    Filed: July 10, 2009
    Publication date: March 11, 2010
    Inventors: Ramesh R. Bhatt, Lawrence Horowitz
  • Combinatorial libraries of conformationally constrained polypeptide sequences
    Publication number: 20100004134
    Abstract: The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses.
    Type: Application
    Filed: January 11, 2008
    Publication date: January 7, 2010
    Inventors: Lawrence Horowitz, Ramesh R. Bhatt, Aaron L. Kurtzman
  • Receptor-binding antiproliferative peptides
    Patent number: 5512435
    Abstract: Methods and composition are provided for identifying antiproliferative polypeptides which inhibit clonal expansion and/or induce apoptosis in cells of a predetermined cell population (e.g., a neoplastic cell sample) expressing a cell surface receptor which is a member of the immunoglobulin superfamily. A predetermined cell population expressing surface immunoglobulin superfamily molecules is isolated from a patient as a cellular sample, such as a lymph node biospy or blood sample containing neoplastic lymphocytic cells. Antiproliferative peptides which are identified by the methods of the invention can be used as therapeutic agents for treating lymphoproliferative disorders by anti-idiotype therapy.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: April 30, 1996
    Inventors: Markus F. Renschler, Ronald Levy, Ramesh R. Bhatt, William J. Dower