Patents by Inventor Ramesh Vaidyanathan

Ramesh Vaidyanathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF ANALYZING NUCLEIC ACIDS
    Publication number: 20240003055
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Application
    Filed: September 6, 2023
    Publication date: January 4, 2024
    Applicant: ILLUMINA, INC.
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Li Grunenwald
  • Methods of analyzing nucleic acids
    Patent number: 11795578
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: October 24, 2023
    Assignee: Illumina, Inc.
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Li Grunenwald
  • METHODS OF ANALYZING NUCLEIC ACIDS
    Publication number: 20220275428
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Application
    Filed: April 25, 2022
    Publication date: September 1, 2022
    Applicant: Epicentre Technologies Corporation
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Li Grunenwald
  • Methods of analyzing nucleic acids
    Patent number: 11339422
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: May 24, 2022
    Assignee: Illumina, Inc.
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Li Grunenwald
  • OLIGONUCLEOTIDE REPLACEMENT FOR DI-TAGGED AND DIRECTIONAL LIBRARIES
    Publication number: 20210261951
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 26, 2021
    Inventors: Igor Goryshin, Bradley Baas, Ramesh Vaidyanathan, Mark Maffitt
  • Oligonucleotide replacement for di-tagged and directional libraries
    Patent number: 11008567
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: May 18, 2021
    Assignee: Illumina, Inc.
    Inventors: Igor Goryshin, Bradley Baas, Ramesh Vaidyanathan, Mark Maffitt
  • METHODS OF ANALYZING NUCLEIC ACIDS
    Publication number: 20200255887
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Application
    Filed: March 26, 2020
    Publication date: August 13, 2020
    Applicant: EPICENTRE TECHNOLOGIES CORPORATION
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Grunenwald
  • Methods of analyzing nucleic acids
    Patent number: 10640809
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 5, 2020
    Assignee: EPICENTRE TECHNOLOGIES CORPORATION
    Inventors: Scott Kuersten, Agnes Radek, Ramesh Vaidyanathan, Haiying Li Grunenwald
  • Modified transposases for improved insertion sequence bias and increased DNA input tolerance
    Patent number: 10544403
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: January 28, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Christian Gloeckner, Amirali Kia, Erin Bomati, Molly He, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan
  • MODIFIED TRANSPOSASES FOR IMPROVED INSERTION SEQUENCE BIAS AND INCREASED DNA INPUT TOLERANCE
    Publication number: 20190359955
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Application
    Filed: April 29, 2019
    Publication date: November 28, 2019
    Inventors: Christian GLOECKNER, Amirali KIA, Erin BOMATI, Molly HE, Haiying Li GRUNENWALD, Scott KUERSTEN, Trina Faye OSOTHPRAROP, Darin HASKINS, Joshua BURGESS, Anupama KHANNA, Daniel SCHLINGMAN, Ramesh VAIDYANATHAN
  • Modified transposases for improved insertion sequence bias and increased DNA input tolerance
    Patent number: 10385323
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 20, 2019
    Assignee: ILLUMINA, INC.
    Inventors: Christian Gloeckner, Amirali Kia, Erin Bomati, Molly He, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan
  • OLIGONUCLEOTIDE REPLACEMENT FOR DI-TAGGED AND DIRECTIONAL LIBRARIES
    Publication number: 20190225960
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Application
    Filed: April 1, 2019
    Publication date: July 25, 2019
    Inventors: IGOR GORYSHIN, BRADLEY BAAS, RAMESH VAIDYANATHAN, MARK MAFFITT
  • Oligonucleotide replacement for di-tagged and directional libraries
    Patent number: 10287574
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 14, 2019
    Assignee: ILLUMINA, INC.
    Inventors: Igor Goryshin, Bradley Baas, Ramesh Vaidyanathan, Mark Maffitt
  • MODIFIED TRANSPOSASES FOR IMPROVED INSERTION SEQUENCE BIAS AND INCREASED DNA INPUT TOLERANCE
    Publication number: 20180298356
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Application
    Filed: June 28, 2018
    Publication date: October 18, 2018
    Applicant: ILLUMINA, INC.
    Inventors: Christian Gloeckner, Amirali Kia, Erin Bomati, Molly He, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan
  • METHOD AND COMPOSITIONS FOR DETECTING PATHOGENIC ORGANISMS
    Publication number: 20180230458
    Abstract: Some embodiments of the present invention relate to the enrichment of non-host nucleic acids in a mixture of host and non-host nucleic acids. Some embodiments include methods for detecting pathogenic organisms from a nucleic acid sample comprising host nucleic acids and nucleic acids indicative of the pathogenic organism.
    Type: Application
    Filed: November 12, 2015
    Publication date: August 16, 2018
    Inventors: Haiying Li Grunenwald, Stephen Paul Bruinsma, Anupama Khanna, Ramesh Vaidyanathan
  • Modified transposases for improved insertion sequence bias and increased DNA input tolerance
    Patent number: 10035992
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: July 31, 2018
    Assignee: ILLUMINA, INC.
    Inventors: Christian Gloeckner, Amirali Kia, Erin Bomati, Molly He, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan
  • MODIFIED TRANSPOSASES FOR IMPROVED INSERTION SEQUENCE BIAS AND INCREASED DNA INPUT TOLERANCE
    Publication number: 20180171311
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Application
    Filed: October 12, 2017
    Publication date: June 21, 2018
    Applicant: ILLUMINA, INC.
    Inventors: Christian GLOECKNER, Amirali KIA, Erin BOMATI, Molly HE, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan
  • METHODS OF ANALYZING NUCLEIC ACIDS
    Publication number: 20180148767
    Abstract: Presented herein are methods and compositions for analyzing rare nucleic acid species. Some methods presented herein use DNA reassociation kinetics following thermal denaturation to define populations of nucleic acid sequences, e.g., highly abundant (e.g., cDNA from rRNA), moderately abundant, and less abundant or rare sequences (e.g., cDNA from mRNA).
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Applicant: EPICENTRE TECHNOLOGIES CORPORATION
    Inventors: Scott KUERSTEN, Agnes RADEK, Ramesh VAIDYANATHAN, Haiying Li GRUNENWALD
  • Selective 5? ligation tagging of RNA
    Patent number: 9963735
    Abstract: The present invention provides novel compositions, kits and methods employing RNA 5? polyphosphatases, RNA 5? monophosphatases, capping enzymes, decapping enzymes, nucleic acid pyrophosphatases and RNA ligases, as well as other enzymes, for selective 5? ligation tagging of desired classes of RNA molecules that differ with respect to particular chemical moieties on their 5? ends. The 5? tagged RNA molecules can be used for synthesis of tagged first-stand cDNA, double-stranded cDNA, and sense or antisense RNA for a variety of uses.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: May 8, 2018
    Assignee: EPICENTRE TECHNOLOGIES CORPORATION
    Inventors: Jerome Jendrisak, Gary A. Dahl, Ramesh Vaidyanathan
  • Modified transposases for improved insertion sequence bias and increased DNA input tolerance
    Patent number: 9790476
    Abstract: Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered transposases and reaction conditions which exhibit improved insertion sequence bias, as well as methods and kits using the same.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: October 17, 2017
    Assignee: ILLUMINA, INC.
    Inventors: Christian Gloeckner, Amirali Kia, Erin Bomati, Molly He, Haiying Li Grunenwald, Scott Kuersten, Trina Faye Osothprarop, Darin Haskins, Joshua Burgess, Anupama Khanna, Daniel Schlingman, Ramesh Vaidyanathan