Abstract: A disposable set and system for dialysis are disclosed. An example peritoneal dialysis system includes an automated peritoneal dialysis (“APD”) machine comprising a pumping mechanism and a peritoneal dialysis fluid heater. The example peritoneal dialysis system also includes a disposable set comprising a disposable cassette operable with the pumping mechanism and a heater bag operable with the heater. The example peritoneal dialysis system additionally includes a conductivity sensor positioned and arranged to provide feedback to the APD machine. The example APD machine is configured to mix a peritoneal dialysis fluid for treatment in the heater bag using a plurality of peritoneal dialysis constituent fluids. In addition, the example APD machine is configured to use feedback from the conductivity sensor to evaluate the mixed peritoneal dialysis fluid for treatment.

Abstract: Cardiac therapy devices in the form of pacemakers and/or defibrillators including one or more leads with electrodes implanted in a vein in a posterior position in combination with one or more leads with electrodes implanted in an anterior position. The posterior position may be chosen from one or more of the azygos, hemiazygos, accessory hemiazygos, or posterior intercostal veins. The anterior position may be chosen from the internal thoracic vein, an anterior intercostal vein, or an anterior subcutaneous location. In other examples, sensors are placed for use by a cardiac monitoring or therapy system in one or more of the internal thoracic vein, the azygos vein, the hemiazygos vein, the accessory hemiazygos vein, and/or an anterior or posterior intercostal vein.

Abstract: Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.

Abstract: An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.

Abstract: A disposable cassette and system for dialysis are disclosed. An example disposable cassette includes a rigid portion, a fluid source inlet configured to be placed in fluid communication with a fluid source, and a fluid pumping receptacle placed in fluid communication with the fluid source inlet. The fluid pumping receptacle is configured to operate with a fluid pump actuator to pump fluid from the fluid source. The example disposable cassette also includes a dampening chamber formed as part of the rigid portion and in fluid communication with the fluid pumping receptacle. The dampening chamber is sized and arranged to reduce pressure fluctuations in the fluid delivered from the fluid pumping receptacle. The example disposable cassette further includes an outlet in fluid communication with the dampening chamber. The outlet provides dialysis fluid for a dialysis treatment.

Abstract: Embodiments herein include systems and methods for detecting, predicting and/or assessing acute kidney injury. In an embodiment, a monitoring system to detect acute kidney injury is included. The monitoring system can include a sensor circuit configured to collect renal data including at least one of systemic renal data, direct renal data, urinary tract data, and renal-relevant extracorporeal data. The monitoring system can also include a memory circuit to store collected renal data, an evaluation circuit to assess renal status, and a telemetry circuit. The evaluation circuit can determine whether acute kidney injury has occurred or is likely to occur by comparing the renal data to at least one of threshold values, personal historical values, patient population values and patterns indicative of acute kidney injury. The evaluation circuit can initiate a warning notification if acute kidney injury has occurred or is likely to occur. Other embodiments are also included herein.

Abstract: An apparatus may include a sensing circuit and a processor. The sensing circuit is configured to generate a sensed physiological signal, wherein the physiological signal includes respiration information of a subject. The processor includes an end expiratory volume (EEV) module configured to determine a value of EEV of the subject using the sensed physiological signal, and a lung hyperinflation detection module configured to generate an indication of lung hyperinflation of the subject according to the value of EEV and provide the indication to at least one of a user or process.

Abstract: A hemodialysis system including (i) a dialyzer, (ii) a blood circuit including a blood pump in fluid communication with the dialyzer, (iii) a dialysate circuit including a dialysate circulation pump in fluid communication with the dialyzer, the dialysate circuit further including a sorbent cartridge for cleaning used dialysate, (iv) a dialysate reservoir, (v) a reservoir pump in fluid communication with the dialysate circuit and the dialysate reservoir, (vi) a supply of concentrate for reconstituting dialysate in the dialysate circuit, and (vii) wherein the hemodialysis system is configured to electronically weigh the dialysate reservoir and the supply of concentrate.

Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.

Abstract: Systems and methods for treating atrial tachyarrhythmias such as atrial fibrillation (AF) are disclosed. By monitoring a patient's hemodynamic sensor response to a candidate AF therapy, the present systems and methods can be used to determine an individualized AF therapy leading to a desirable hemodynamic outcome. A medical system can include one or more programmable therapy circuits and a hemodynamic sensor circuit. The system includes a therapy selection circuit that automatically programs and sequentially delivers at least a first candidate therapy and a different second candidate therapy. By comparing the values of a hemodynamic parameter in response to or during the first candidate therapy to that in response to or during the second candidate therapy, a desired AF therapy can be determined as the candidate therapy that leads to faster or more significant hemodynamic recovery.

Abstract: A regenerative peritoneal dialysis system includes a dialysis fluid loop; a filter located in the dialysis fluid loop, a first portion of the dialysis fluid sent to the filter rejected by the filter and returned upstream of the filter, a second portion of the dialysis fluid sent to the filter forming permeate, the permeate being rich in urea; and a urea removing apparatus located in the dialysis fluid loop downstream from the filter to receive the permeate and absorb urea from the permeate.

Abstract: Systems and methods for detecting a worsening of patient's heart failure condition based, at least in part, on an increasing trend in a representative rapid shallow breathing index (RSBI) value over multiple days. The RSBI value may be a minimum RSBI, and more particularly may be a minimum RSBI value determined for an afternoon portion of each of the multiple days. The minimum RSBI value measured during an afternoon portion of the day may be more sensitive to changes in a patient's respiration, particularly when a patient is expected to be more active, and thus, may more readily exhibit an increasing trend when patient's heart failure is in decline.

Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.

Abstract: Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition.

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract: Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition.

Abstract: A system includes a therapy control circuit, a therapy output circuit; and a physiologic interval sensing circuit configured to receive information about subject physiologic intervals. The therapy circuit is configured to determine a change in therapy that is provided by the therapy output circuit, determine that the change in therapy includes a change to a maximum interval of cardiac electrostimulation provided according to the therapy, detecting a change in a ventricular filling characteristic of the subject in response to the change in maximum interval of cardiac electrostimulation, determine an indication of a physiologic response of the subject to the therapy change using information about the change in the ventricular filling characteristic, and update the subject therapy provided by the therapy output circuit when the determined indication of the physiologic response to the therapy change indicates an increased likelihood of worsening health status of the subject.

Abstract: Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract: The present document discusses medical device systems and related methods. In an embodiment, a medical device system can include a cardiac device. The cardiac device can include a processor, a memory, a communications circuit, and one or more sensors. The cardiac device can be configured to engage a sensor mode specific for patients receiving or having implanted ventricular assist devices. The cardiac device can be configured to process data as specified by the sensor mode specific for patients receiving or having implanted ventricular assist devices. In an embodiment, a method for monitoring heart failure patients is discussed. In an embodiment, a method of controlling devices for heart failure patients is discussed. Other embodiments are also included herein.