Abstract: Expandable Jacket surrounding a pressuremeter probe prevents barrel shape to form and maintains cylindrical shape with uniform radial displacement throughout its height, removing shortcomings of the existing pressuremeters. For the pressuremeter probe to determine horizontal stress versus plane strain relationship in soils and intermediate geomaterials, an expandable comprises of one layer of circular arch shaped segmented plates surrounded by flexible bands or rings. The expandable jacket surrounds a membrane which itself surrounds a porous tube with holes. Borehole less than the diameter of probe is drilled either by pre-boring or self-boring and then pushing the probe with cutter ring.

Abstract: The present invention is directed to methods of producing substituted pyrazole based compounds through novel intermediates and unique processes for preparing such intermediates which enables synthesis of final product through commercially viable route of synthesis. The present invention is also directed to novel methods of producing substituted pyrazole based thyroid like compounds, and solid forms of 3-{4-[(7-hydroxy-6-methyl-indan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}-propanoic acid, its pharmaceutical compositions, and methods of preparation thereof.

Abstract: The porous displacement piles comprising (a) closed-ended pipe piles with small holes and or narrow slots, filled with compacted sandy soil, (b) closed-ended porous pipe piles such as closed-ended pipe pile with very small holes and or very narrow slots, and (c) a precast prestressed porous concrete piles are driven through inside the already driven non-displacement hollow pipe piles in a grid pattern to create excess pore-water pressures generally ranging between 50 and 1500 kPa in cohesive soils, which begin dissipating through inside the porous displacement piles to rapidly consolidate and densify the said cohesive soil. The porous displacement piles are designed for permitting free flow of the pressurized pore-water and to prevent migration of particles of cohesive soil into the porous displacement pile using filter design criteria or verified by laboratory tests. These piles when driven in sandy soils densify sandy soils instantaneously.

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

Abstract: The porous displacement piles comprising (a) closed-ended pipe piles with small holes and or narrow slots, filled with compacted sandy soil, (b) closed-ended porous pipe piles such as closed-ended pipe pile with very small holes and or very narrow slots, and (c) a precast prestressed porous concrete piles are driven through inside the already driven non-displacement hollow pipe piles in a grid pattern to create excess pore-water pressures generally ranging between 50 and 1500 kPa in cohesive soils, which begin dissipating through inside the porous displacement piles to rapidly consolidate and densify the said cohesive soil. The porous displacement piles are designed for permitting free flow of the pressurized pore-water and to prevent migration of particles of cohesive soil into the porous displacement pile using filter design criteria or verified by laboratory tests. These piles when driven in sandy soils densify sandy soils instantaneously.

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

Abstract: The present invention is directed to methods of producing substituted pyrazole based compounds through novel intermediates and unique processes for preparing such intermediates which enables synthesis of final product through commercially viable route of synthesis. The present invention is also directed to novel methods of producing substituted pyrazole based thyroid like compounds, and solid forms of 3-{4-[(7-hydroxy-6-methyl-indan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}-propanoic acid, its pharmaceutical compositions, and methods of preparation thereof.

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

Abstract: Subsurface exploration using In-Situ tests such as SPT, CPT, CPTu, DMT, and PMT predicts inaccurately engineering properties of soils and intermediate geomaterials and thereby predicts incorrect load-settlement relationship of piles; variations or errors in engineering properties predicted by one empirical correlation to another correlation could be up to 50% or greater. For soft to very soft soils, engineering properties cannot be predicted as the SPT only provides information such as WOR and WOH. To overcome this problem, the invention of the application consists of performing subsurface exploration using load tests on short model piles with or without instrumentation at various depths of a soil deposit for determining accurately the above-mentioned properties. For very soft soils, a hung balance is used to hang drill rods and short model pile from a drill rig boom or from a platform with soil anchors to prevent its overturning, and then perform the load test.

Abstract: This invention relates to pharmaceutical formulations comprising 1-(2-thien-2?-yl-2-oxo-ethyl)-3-(methanesulfonyl hydrazine carbonyl) pyridinium, its pharmaceutically acceptable salts, salt-cocrystals and co-crystals, particularly 1-(2-thien-2?-yl-2-oxo-ethyl)-3-5(methanesulfonyl hydrazine carbonyl) pyridinium chloride. The formulations are suitable for oral administration and also comprise a permeability enhancer or a suitable base or a mixture thereof. The formulations of this invention are for treating diseases associated with advanced glycation end products.

Abstract: Provided herein are novel fused pyrimidinone derivatives of Formula I and synthetic intermediates that are useful in preparing the compounds of formula (I). Further provided herein is a method for preparation of a compound of formula (I) or intermediates, a pharmaceutical composition comprising a compound of formula (I), and use of a compound of formula (I).

Abstract: The expandable jacket and flexible ring comprises of the segmented circular arch shaped plates and bands or rings around the segmented plates. The test preparation consists of a membrane surrounding a specimen with or without a filter, segmented plates surrounding the membrane, and bands or rings around the segmented plates to permit uniform radial expansion of the specimen through its height when increments of vertical load are applied during the test, thereby providing accurate values of area of cross-section, deviator stress, volume change, modulus of elasticity, Poisson's ratio and shear strength. Using the flexible ring, three-dimensional consolidation tests are performed to determine three-dimensional coefficient of consolidation and coefficients of consolidation in horizontal and vertical directions. Removable attachments are used for assembling the expandable jacket and flexible ring during the test.

Abstract: The expandable jacket and flexible ring comprises of the segmented circular arch shaped plates and bands or rings around the segmented plates. The test preparation consists of a membrane surrounding a specimen with or without a filter, segmented plates surrounding the membrane, and bands or rings around the segmented plates to permit uniform radial expansion of the specimen through its height when increments of vertical load are applied during the test, thereby providing accurate values of area of cross-section, deviator stress, volume change, modulus of elasticity, Poisson's ratio and shear strength. Using the flexible ring, three-dimensional consolidation tests are performed to determine three-dimensional coefficient of consolidation and coefficients of consolidation in horizontal and vertical directions. Removable attachments are used for assembling the expandable jacket and flexible ring during the test.

Abstract: This invention relates to pharmaceutical formulations comprising 1-(2-thien-2?-yl-2-oxo-ethyl)-3-(methanesulfonyl hydrazine carbonyl) pyridinium, its pharmaceutically acceptable salts, salt-cocrystals and co-crystals, particularly 1-(2-thien-2?-yl-2-oxo-ethyl)-3-5(methanesulfonyl hydrazine carbonyl) pyridinium chloride. The formulations are suitable for oral administration and also comprise a permeability enhancer or a suitable base or a mixture thereof.

Abstract: The expandable jacket consists of the rubber membrane surrounding the cylindrical specimen, circular segmental metal plates surrounding the rubber membrane, and elastomeric rubber bands or rings around the segmental plates to permit uniform radial expansion and maintain uniform diameter of the specimen during the test and thereby providing accurate values of deviator stress, volume change characteristics and shear strength of soil specimen. To determine the three-dimensional coefficient of consolidation and coefficient of consolidation in horizontal direction, the flexible ring consists of all above structural components of expandable jacket except that a filter fabric or paper is wrapped around the cylindrical specimen, and then rubber membrane is mounted surrounding the filter paper or paper.

Abstract: A test device has been invented for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of the excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in the horizontal and vertical directions, and the modulus of elasticity. The flexible ring consists of a filter fabric around the soil specimen, a rubber membrane around the filter, circular shaped segmented stainless steel plates around the membrane and rubber bands around the plates. Both the incremental loading or triaxial type loading systems can be used with this device. A calibration device for calibration of the flexible ring is used to determine the modulus of elasticity of elastic elements, required for calculating lateral resistance provided by the flexible ring during the test.

Abstract: A test device has been invented for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of the excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in the horizontal and vertical directions, and the modulus of elasticity. The flexible ring consists of a filter fabric around the soil specimen, a rubber membrane around the filter, circular shaped segmented metal plates around the membrane and rubber bands or rings around the plates. Both the incremental loading or triaxial type loading systems can be used with this device. A calibration device for calibration of the flexible ring is used to determine the modulus of elasticity of elastic elements, required for calculating lateral resistance provided by the flexible ring during the test.

Abstract: Standard test methods using a fixed ring for determining one-dimensional consolidation properties of soils represent a subsurface condition where settlement and dissipation of excess pore pressure is possible only in vertical direction. This subsurface condition never occurs, as settlements and dissipation of excess pore pressures always occur in horizontal and vertical directions. Dr. Ramesh Gupta has invented a test device for determining three-dimensional consolidation properties of soils, using a flexible ring permitting displacements and dissipation of excess pore pressures in both horizontal and vertical directions, and affording determination of coefficients of consolidation in horizontal and vertical directions including three-dimensional coefficient of consolidation, and modulus of elasticity.

Abstract: During triaxial compression test, a soil specimen experiences reduction of its height with increase in its diameter. New cross-sectional area is calculated assuming uniform increase in diameter. This condition is seldom met in actual soil specimens, because specimen undergoes non-uniform increase in diameter and very often with localized bulging in specimen affecting the accuracy of calculation of deviator stress, shears strength and volume change characteristics. The expandable jacket included in this invention consists of circular segmental metal plates wrapped around the soil specimen and elastomeric rubber bands or rings around the segmental plates to permit uniform radial expansion and maintain uniform diameter of the specimen during the test and thereby providing accurate values of deviator stress, volume change characteristics and shear strength of soil specimen. The calibration device for calibration of expandable jacket shall provide the magnitude of correction to be made in deviator stress.