Patents by Inventor Rami Jaafar

Rami Jaafar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin-Associated Polypeptides and Uses Thereof
    Publication number: 20240189397
    Abstract: Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 13, 2024
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar
  • REGENERATIVE POLYPEPTIDES AND USES THEREOF
    Publication number: 20240043484
    Abstract: Described herein are polypeptides comprising an FGF17, IGF2, or BMP7 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: September 20, 2023
    Publication date: February 8, 2024
    Inventors: Hanadie YOUSEF, Jeremy O'CONNELL, Thach MAI, Rami JAAFAR, Zhihua LI
  • Heparin-Associated Polypeptides and Uses Thereof
    Publication number: 20230405089
    Abstract: Described herein are therapeutic compositions comprising heparin-associated polypeptides useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries.
    Type: Application
    Filed: February 1, 2023
    Publication date: December 21, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar
  • Regenerative Polypeptides and Uses Thereof
    Publication number: 20230398187
    Abstract: Described herein are polypeptides comprising an FGF17, IGF2, or BMP? amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: December 22, 2020
    Publication date: December 14, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar, Zhihua Li
  • Regenerative Polypeptides and Uses Thereof
    Publication number: 20230312663
    Abstract: Described herein are polypeptides comprising an FGF17, IGF2, or BMP7 amino acid sequence and an amino acid sequence from a heterologous polypeptide useful for the treatment of soft-tissue and muscle diseases, disorders, and injuries. Also described herein are synergistic combinations of a Fibroblast Growth Factor Receptor agonist and a glycosaminoglycan, an Insulin-like Growth Factor 1 Receptor (IGF1R) agonist and a short chain fatty acid, and BMP receptor agonists and mTOR activators and/or glycosaminoglycans. Also described are methods of treating muscle and soft-tissue diseases comprising administering the polypeptides and/or synergistic compositions.
    Type: Application
    Filed: February 1, 2023
    Publication date: October 5, 2023
    Applicant: Juvena Therapeutics, Inc.
    Inventors: Hanadie Yousef, Jeremy O'Connell, Thach Mai, Rami Jaafar, Zhihua Li