Abstract: The present invention provides compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds, including compounds of Formula (I) or prodrugs thereof; optionally in combination with an additional cancer therapeutic agent, and methods of use thereof for treating proliferative diseases and disorders such as Desmoid tumors.

Abstract: Data mining from remote and disparate data providers is enabled without the need for local arranging and processing. Users have a single “point of entry” to data providers that allows query submission, data collection and assembly, and performing various operations on the datasets obtained from the various data providers (e.g. web databases). The operations on the dataset do not require any change in the format or semantics used by the various data providers. The user is also able to structure a mining strategy without having to visit any of the database provider's websites and without having to download any data from these websites.