Abstract: The present invention allows for non-invasive monitoring of the blood sugar levels in diabetic patients. At least one heat and waterproof applicator is applied to the skin surface by a dosage pressure. Temporal dynamics of physiological parameters of the local tissue region are measured under the applicator. Temporal dynamics of climatic parameters of the environment are measured simultaneously or before the beginning of measurement of physiological parameters in the monitoring mode. Further, enthalpy of tissue is calculated with account for the influence of climatic parameters. Magnitude of thermal effect of metabolism of the local area of living tissue is calculated on the basic thermodynamics equation, connecting enthalpy of tissue with variables of thermodynamic state. Relative changes in the level of glucose are calculated in blood, proportional to the value of the thermal metabolism of the local area of living tissue.

Abstract: The present group of inventions relates to medicine and medical technology, more particularly to non-invasive methods and devices for monitoring blood glucose level based on absorption isothermal calorimetric spectroscopy, which allows the content of biochemical components in living tissue to be determined in real time. The present invention also relates to methods for producing a biopolymer molecule with given biological properties and a given three-dimensional structure. The use of the group of inventions makes it possible to carry out non-invasive monitoring of the blood sugar level of patients with diabetes, including for the purpose of early diagnosis of diabetes mellitus.

Abstract: The present invention allows for non-invasive monitoring of the blood sugar levels in diabetic patients. At least one heat and waterproof applicator is applied to the skin surface by a dosage pressure. Temporal dynamics of physiological parameters of the local tissue region are measured under the applicator. Temporal dynamics of climatic parameters of the environment are measured simultaneously or before the beginning of measurement of physiological parameters in the monitoring mode. Further, enthalpy of tissue is calculated with account for the influence of climatic parameters. Magnitude of thermal effect of metabolism of the local area of living tissue is calculated on the basic thermodynamics equation, connecting enthalpy of tissue with variables of thermodynamic state. Relative changes in the level of glucose are calculated in blood, proportional to the value of the thermal metabolism of the local area of living tissue.

Abstract: The present invention relates to medicine, in particular, to the methods of measuring a thermal effect and a local metabolism rate of a live tissue, a water content in the intercellular substance as well as a concentration of biochemical blood components, in particular, blood glucose and pressure in the cardiovascular system.