Patents by Inventor Ramiro Garzon

Ramiro Garzon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY MODIFIED CELLS AND USES THEREOF FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE
    Publication number: 20240124840
    Abstract: The present disclosure relates to compositions and methods for preventing and treating acute graft-versus-host disease.
    Type: Application
    Filed: February 22, 2022
    Publication date: April 18, 2024
    Inventors: Parvathi RANGANATHAN, Ramiro GARZON
  • RECOMBINANT EGFL7, EGFL7 ANTIBODIES, AND USES THEREOF
    Publication number: 20240043519
    Abstract: The present disclosure relates to recombinant EGFL7, EGFL7 antibodies, and uses thereof.
    Type: Application
    Filed: July 11, 2023
    Publication date: February 8, 2024
    Inventors: Adrienne M. DORRANCE, Ramiro GARZON
  • Recombinant EGFL7, EGFL7 antibodies, and uses thereof
    Patent number: 11702469
    Abstract: The present disclosure relates to recombinant EGFL7, EGFL7 antibodies, and uses thereof.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: July 18, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Adrienne M. Dorrance, Ramiro Garzon
  • TARGETING CIRCULAR PCMTD1 IN LEUKEMIAS WITH P53 MUTATIONS AND/OR BCR/ABL FUSIONS
    Publication number: 20220396636
    Abstract: Disclosed are methods relating to the use of circular PCMTD1 as a diagnostic and prognostic marker for leukemias and cancers with a p53 mutation and/or BCR/ABL fusions. Additionally, disclosed herein are oligonucleotides and antibodies that can be used to identify the circular PCMTD1 for use in the diagnostic and prognostic methods and target the circular PCMTD1 in treatment methods.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 15, 2022
    Inventors: Ramiro GARZON, Dimitrios PAPAIOANNOU
  • MATERIALS AND METHODS FOR MODIFYING THE ACTIVITY OF T CELLS
    Publication number: 20220348870
    Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.
    Type: Application
    Filed: July 13, 2022
    Publication date: November 3, 2022
    Inventors: Bruce R. Blazar, Keli Hippen, Pavan Reddy, Yaping Sun, Ramiro Garzon
  • Materials and methods for modifying the activity of T cells
    Patent number: 11390848
    Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 19, 2022
    Assignees: Regents of the University of Minnesota, Regents of the University of Michigan, The Ohio State University
    Inventors: Bruce R. Blazar, Keli Hippen, Pavan Reddy, Yaping Sun, Ramiro Garzon
  • Antisense oligomers targeting HOXB-AS3 long non-coding RNA
    Patent number: 10787665
    Abstract: The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: September 29, 2020
    Assignees: Ohio State Innovation Foundation, Aalborg University
    Inventors: Ramiro Garzon, Adrienne Dorrance, Dimitrios Papaioannou, Robert Lee, Sakari Kauppinen, Andreas Petri, Charlotte AlbÆk Thrue
  • RECOMBINANT EGFL7, EGFL7 ANTIBODIES, AND USES THEREOF
    Publication number: 20200277363
    Abstract: The present disclosure relates to recombinant EGFL7, EGFL7 antibodies, and uses thereof.
    Type: Application
    Filed: April 24, 2018
    Publication date: September 3, 2020
    Inventors: Adrienne M. DORRANCE, Ramiro GARZON
  • ANTISENSE OLIGOMERS TARGETING HOXB-AS3 LONG NON-CODING RNA
    Publication number: 20190256848
    Abstract: The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.
    Type: Application
    Filed: November 3, 2017
    Publication date: August 22, 2019
    Inventors: Ramiro GARZON, Adrienne DORRANCE, Dimitrios PAPAIOANNOU, Robert LEE, Sakari KAUPPINEN, Andreas PETRI, Charlotte ALBÆK THRUE
  • MATERIALS AND METHODS FOR MODIFYING THE ACTIVITY OF T CELLS
    Publication number: 20190203173
    Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 4, 2019
    Applicant: Regents of the University of Minnesota
    Inventors: Bruce R. Blazar, Keli Hippen, Pavan Reddy, Yaping Sun, Ramiro Garzon
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8911936
    Abstract: Described herein are methods of diagnosing a cancer and/or myeloproliferative disorder using microRNAs. Also described are compositions and methods related to cancers and myeloproliferative disorders.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: December 16, 2014
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8865885
    Abstract: Described herein is a pharmaceutical composition for treating a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: October 21, 2014
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20140161869
    Abstract: Described herein are compositions and methods of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Application
    Filed: June 25, 2013
    Publication date: June 12, 2014
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20130273151
    Abstract: Described herein is a pharmaceutical composition for treating a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 17, 2013
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA Fingerprints During Human Megakaryocytopoiesis
    Publication number: 20130274140
    Abstract: Described herein are methods of diagnosing a cancer and/or myeloproliferative disorder using microRNAs. Also described are compositions and methods related to cancers and myeloproliferative disorders.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 17, 2013
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors
    Publication number: 20130236453
    Abstract: Methods and compositions for treating or preventing acute graft-versus-host disease (aGVHD) in a subject using miR-155 specific inhibitors are described.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Ramiro Garzon
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8492083
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 23, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486912
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486913
    Abstract: Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8354224
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer and myeloproliferative disorders. The invention also provides methods of identifying anti-cancer agents.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: January 15, 2013
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin