Patents by Inventor Ramiro Jover Atienza

Ramiro Jover Atienza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR OBTAINING A SINGULAR CELL MODEL CAPABLE OF REPRODUCING IN VITRO THE METABOLIC IDIOSYNCRASY OF HUMANS
    Publication number: 20120034642
    Abstract: The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualized expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs.
    Type: Application
    Filed: July 1, 2011
    Publication date: February 9, 2012
    Applicant: ADVANCED IN VITRO CELL TECHNOLOGIES, S.L.
    Inventors: JOSÉ VICENTE CASTELL RIPOLL, MARÍA JOSÉ GÓMEZ-LECHÓN, RAMIRO JOVER ATIENZA, AGUSTÍN LAHOZ RODRÍGUEZ
  • Method for Obtaining a Singular Cell Model Capable of Reproducing in Vitro the Metabolic Idiosyncrasy of Humans
    Publication number: 20080044845
    Abstract: The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualised expression of an enzyme without affecting the other enzymes. This singular cell model can reproduce in vitro the metabolic idiosyncrasy of humans. It is applicable in the study of development of new drugs, specifically in the study of metabolism, potential idiosyncratic hepatotoxicity, medicament interactions, etc., of new drugs.
    Type: Application
    Filed: January 19, 2004
    Publication date: February 21, 2008
    Inventors: Jose Vicente Castell Ripoll, Maria Jose Gomez-Lechon, Ramiro Jover Atienza, Agustin Lahoz Rodriguez