Patents by Inventor Ramkrishna Reddy Vakiti

Ramkrishna Reddy Vakiti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Publication number: 20240002391
    Abstract: 4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).
    Type: Application
    Filed: June 23, 2023
    Publication date: January 4, 2024
    Inventors: Gopi Kumar Mittapalli, Chi Ching Mak, Lewis Daniel Turner, Brian Joseph Hofilena, Ramkrishna Reddy Vakiti, Brian Walter Eastman, David Mark Wallace
  • PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Publication number: 20230312605
    Abstract: Pyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of pyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer’s disease, diabetes, viral infections, and osteoarthritis).
    Type: Application
    Filed: October 12, 2022
    Publication date: October 5, 2023
    Inventors: Gopi Kumar Mittapalli, Sunil Kumar KC, Chi Ching Mak, Brian Joseph Hofilena, Lewis Daniel Turner, Brian Walter Eastman, Ramkrishna Reddy Vakiti, Joseph Timothy Marakovits
  • 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF
    Publication number: 20230167133
    Abstract: 7H-Pyrrolo[2,3-d]pyrimidine compound for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 7H-pyrrolo[2,3-d]pyrimidine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).
    Type: Application
    Filed: October 12, 2022
    Publication date: June 1, 2023
    Inventors: Gopi Kumar Mittapalli, Sunil Kumar KC, Chi Ching Mak, Brian Joseph Hofilena, Chandramouli Chiruta, Ramkrishna Reddy Vakiti, Brian Walter Eastman, Joseph Timothy Marakovits, Lewis Daniel Turner
  • OXOPIPERAZINE DERIVATIVES
    Publication number: 20220213057
    Abstract: The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
    Type: Application
    Filed: January 7, 2022
    Publication date: July 7, 2022
    Inventors: Marc LABELLE, Ulrich KESSLER, Valentino CATTORI, Cyril COOK, Ramkrishna Reddy VAKITI, Kevin R. D. JOHNSON, Matinder KAUR, Jean-d'Amour K. TWIBANIRE, Farman ULLAH
  • Oxopiperazine derivatives
    Patent number: 11306068
    Abstract: The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: April 19, 2022
    Assignee: Inthera Bioscience AG
    Inventors: Marc Labelle, Ulrich Kessler, Valentino Cattori, Cyril Cook, Ramkrishna Reddy Vakiti, Kevin R. D. Johnson, Matinder Kaur, Jean-d'amour K. Twibanire, Farman Ullah
  • OXOPIPERAZINE DERIVATIVES
    Publication number: 20200308139
    Abstract: The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
    Type: Application
    Filed: June 3, 2020
    Publication date: October 1, 2020
    Inventors: Marc LABELLE, Ulrich KESSLER, Valentino CATTORI, Cyril COOK, Ramkrishna Reddy VAKITI, Kevin R. D. JOHNSON, Matinder KAUR, Jean-d'Amour K. TWIBANIRE, Farman ULLAH
  • Oxopiperazine derivatives
    Patent number: 10710975
    Abstract: The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: July 14, 2020
    Assignee: Inthera Bioscience AG
    Inventors: Marc Labelle, Ulrich Kessler, Valentino Cattori, Cyril Cook, Ramkrishna Reddy Vakiti, Kevin R. D. Johnson, Matinder Kaur, Jean-d'Amour K. Twibanire, Farman Ullah
  • OXOPIPERAZINE DERIVATIVES
    Publication number: 20190185449
    Abstract: The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 20, 2019
    Inventors: Marc LABELLE, Ulrich KESSLER, Valentino CATTORI, Cyril COOK, Ramkrishna Reddy VAKITI, Kevin R. D. JOHNSON, Matinder KAUR, Jean-d'Amour K. TWIBANIRE, Farman ULLAH
  • Compounds and methods for inhibiting histone demethylases
    Patent number: 9802941
    Abstract: The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure: wherein Q, R1, R18, R19, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: October 31, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Thomas Boesen, Marc Labelle, Ying Yang, Neerja Saraswat, Dastagiri Dudekula, Cyril John Cook, Ramkrishna Reddy Vakiti, Rui Zhang, Farman Ullah
  • Inhibitors of histone demethylases
    Patent number: 9650339
    Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: May 16, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Marc Labelle, Thomas Boesen, Qasim Khan, Ramkrishna Reddy Vakiti, Utpal Sharma, Ying Yang, Mukund Mehrotra, Neerja Saraswat, Farman Ullah
  • INHIBITORS OF HISTONE DEMETHYLASES
    Publication number: 20160237037
    Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 18, 2016
    Inventors: Marc Labelle, Thomas Boesen, Qasim Khan, Ramkrishna Reddy Vakiti, Utpal Sharma, Ying Yang, Mukund Mehrotra, Neerja Saraswat, Farman Ullah
  • COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES
    Publication number: 20160102096
    Abstract: The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure: wherein Q, R1, R18, R19, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.
    Type: Application
    Filed: August 26, 2015
    Publication date: April 14, 2016
    Inventors: Thomas Boesen, Marc Labelle, Ying Yang, Neerja Saraswat, Dastagiri Dudekula, Cyril John Cook, Ramkrishna Reddy Vakiti, Rui Zhang, Farman Ullah
  • Inhibitors of histone demethylases
    Patent number: 9221801
    Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: December 29, 2015
    Assignee: Epitherapeutics APS
    Inventors: Marc Labelle, Thomas Boesen, Qasim Khan, Ramkrishna Reddy Vakiti, Utpal Sharma, Ying Yang, Mukund Mehrotra, Neerja Saraswat, Farman Ullah
  • INHIBITORS OF HISTONE DEMETHYLASES
    Publication number: 20140371214
    Abstract: Compounds of the form In which Q is selected from —CH?NR12, —W, —CH2NHR13, —CH?O and —CH(OR17)2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Inventors: Marc Labelle, Thomas Boesen, Qasim Khan, Ramkrishna Reddy Vakiti, Utpal Sharma, Ying Yang, Mukund Mehrotra, Neerja Saraswat, Farman Ullah