Patents by Inventor Ramkumar Rajamani

Ramkumar Rajamani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRas inhibitors
    Patent number: 12723053
    Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Grant
    Filed: March 29, 2024
    Date of Patent: September 1, 2026
    Assignee: Eli Lilly and Company
    Inventors: Adedoyin David Abraham, Alberto Valero De La Cruz, Alicia Marcos Llorente, Alvaro Enriquez Garcia, Andrew Dilger, Deqi Guo, Desta Bume, Frederic Laurent Cordier, Gaiying Zhao, Isabel Rojo Garcia, James Robert Henry, Jason Eric Lamar, Jolie Anne Bastian, Maria Lourdes Prieto Vallejo, Mario Barberis, Matthew Patrick Baumgartner, Miguel Garzón Sanz, Pablo Garcia Losada, Ramkumar Rajamani, Richard Duane Johnston, Robert Hazlitt, Santiago Carballares Martin, Sean Aronow, Shane Michael Walls, Sonia Maria Gutierrez Sanfeliciano, Steven Andrews, Timothy Scott Kercher, Victoriano Molero Flórez, Wenceslao Lumeras Amador, William Rush Scaggs, Juan Antonio Rincon Cabezudo, Julián Priego Soler, Xiaohong Chen
  • KRAS inhibitors
    Patent number: 12691117
    Abstract: The present invention provides compounds of the formula: wherein R1, R2, R3, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients with cancer.
    Type: Grant
    Filed: September 10, 2025
    Date of Patent: July 28, 2026
    Assignee: ELI LILLY AND COMPANY
    Inventors: Sean Aronow, Mario Barberis, Alexandra Bosnidou, Desta Bume, Xiaohong Chen, Sonia Maria Gutierrez Sanfeliciano, Timothy Scott Kercher, Wenceslao Lumeras Amador, Alicia Marcos Llorente, Julian Priego Soler, Maria Lourdes Prieto Vallejo, Ramkumar Rajamani, Isabel Rojo Garcia, William Rush Scaggs, Victoriano Molero Flórez
  • KRAS INHIBITORS
    Publication number: 20260166037
    Abstract: The present invention provides compounds of the formula: wherein R1, R2, R3, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients with cancer.
    Type: Application
    Filed: September 10, 2025
    Publication date: June 18, 2026
    Inventors: Sean ARONOW, Mario BARBERIS, Alexandra BOSNIDOU, Desta BUME, Xiaohong CHEN, Sonia Maria GUTIERREZ SANFELICIANO, Timothy Scott KERCHER, Wenceslao LUMERAS AMADOR, Alicia MARCOS LLORENTE, Julian PRIEGO SOLER, Maria Lourdes PRIETO VALLEJO, Ramkumar RAJAMANI, Isabel ROJO GARCIA, William Rush SCAGGS, Victoriano MOLERO FLÓREZ
  • KRAS inhibitors
    Patent number: 12600733
    Abstract: Provided herein are compounds of the formula: wherein A, B, R1, R2, R3a, R3b, Z1, Z2, and Z3 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients with cancer.
    Type: Grant
    Filed: September 30, 2025
    Date of Patent: April 14, 2026
    Assignee: ELI LILLY AND COMPANY
    Inventors: Adedoyin David Abraham, Sean Aronow, Desta Bume, Xiaohong Chen, Sonia Maria Gutierrez Sanfeliciano, Timothy Scott Kercher, Wenceslao Lumeras Amador, Ramkumar Rajamani, Isabel Rojo Garcia, William Rush Scaggs, Shane Walls
  • KRAS INHIBITORS
    Publication number: 20260092075
    Abstract: Provided herein are compounds of the formula: wherein A, B, R1, R2, R3a, R3b, Z1, Z2, and Z3 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients with cancer.
    Type: Application
    Filed: September 30, 2025
    Publication date: April 2, 2026
    Inventors: Adedoyin David ABRAHAM, Sean ARONOW, Desta BUME, Xiaohong CHEN, Sonia Maria GUTIERREZ SANFELICIANO, Timothy Scott KERCHER, Wenceslao LUMERAS AMADOR, Ramkumar RAJAMANI, Isabel ROJO GARCIA, William Rush SCAGGS, Shane WALLS
  • PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS
    Publication number: 20250214970
    Abstract: The present disclosure is directed to compounds of formula (I): wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
    Type: Application
    Filed: November 5, 2024
    Publication date: July 3, 2025
    Inventors: Verner Alexander LOFSTRAND, Jung Yun KIM, Helen CLEMENT, Kristen Nicole BURFORD, Paul CHARIFSON, Shawn JOHNSTONE, Juliette SABBATANI, Jan Felix SCHOLTES, Wei ZHANG, Shaoyi SUN, Michael CLARK, Steve WESOLOWSKI, Ravi MUNUGANTI, Ramkumar RAJAMANI
  • KRAS INHIBITORS
    Publication number: 20240368193
    Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Application
    Filed: March 29, 2024
    Publication date: November 7, 2024
    Inventors: Adedoyin David ABRAHAM, Alberto VALERO DE LA CRUZ, Alicia MARCOS LLORENTE, Alvaro ENRIQUEZ GARCIA, Andrew DILGER, Deqi GUO, Desta BUME, Frederic LAURENT CORDIER, Gaiying ZHAO, Isabel ROJO GARCIA, James Robert HENRY, Jason Eric LAMAR, Jolie Anne BASTIAN, Maria Lourdes PRIETO VALLEJO, Mario BARBERIS, Matthew Patrick BAUMGARTNER, Miguel GARZÓN SANZ, Pablo GARCIA LOSADA, Ramkumar RAJAMANI, Richard Duane JOHNSTON, Robert HAZLITT, Santiago CARBALLARES MARTIN, Sean ARONOW, Shane Michael WALLS, Sonia Maria GUTIERREZ SANFELICIANO, Steven ANDREWS, Timothy Scott KERCHER, Victoriano MOLERO FLÓREZ, Wenceslao LUMERAS AMADOR, William Rush SCAGGS, Juan Antonio RINCON CABEZUDO, Julián PRIEGO SOLER, Xiaohong CHEN
  • KRAS INHIBITORS
    Publication number: 20240343736
    Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.
    Type: Application
    Filed: March 29, 2024
    Publication date: October 17, 2024
    Inventors: Timothy Scott KERCHER, Desta BUME, Andrew DILGER, Adedoyin David ABRAHAM, Alberto VALERO DE LA CRUZ, Julián PRIEGO SOLER, Maria Lourdes PRIETO VALLEJO, Mario BARBERIS, Miguel GARZÓN SANZ, Ramkumar RAJAMANI, Sean ARONOW, Shane Michael WALLS, Sonia Maria GUTIERREZ SANFELICIANO, Victoriano MOLERO FLÓREZ, Xiaohong CHEN
  • PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS
    Publication number: 20230203007
    Abstract: The present disclosure is directed to compounds of formula (I): wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
    Type: Application
    Filed: September 23, 2022
    Publication date: June 29, 2023
    Inventors: Verner Alexander Lofstrand, Jung Yun Kim, Helen Clement, Kristen Nicole Burford, Paul Charifson, Shawn Johnstone, Juliette Sabbatani, Jan Felix Scholtes, Wei Zhang, Shaoyi Sun, Michael Clark, Steve Wesolowski, Ravi Munuganti, Ramkumar Rajamani
  • 4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication
    Patent number: 11505543
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 22, 2022
    Assignee: VIIV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Makonen Belema, John A. Bender, David B. Frennesson, Eric P. Gillis, Christiana Iwuagwu, John F. Kadow, B. Narasimhulu Naidu, Kyle E. Parcella, Kevin M. Peese, Ramkumar Rajamani, Mark G. Saulnier, Alan Xiangdong Wang, Manoj Patel, Michael S. Bowsher
  • Inhibitors of human immunodeficiency virus replication
    Patent number: 10954252
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: March 23, 2021
    Assignee: ViiV HEALTHCARE UK (NO.5) LIMITED
    Inventors: Suresh Babu, Makonen Belema, John A. Bender, Christiana Iwuagwu, John F. Kadow, Selvakumar Kumaravel, Pulicharla Nagalakshmi, B. Narasimhulu Naidu, Manoj Patel, Kevin M. Peese, Ramkumar Rajamani, Mark Saulnier, Alan Xiangdong Wang
  • 4-OXO-3,4-DIHYDROQUINAZOLINE COMPOUNDS AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
    Publication number: 20210024503
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
    Type: Application
    Filed: April 11, 2019
    Publication date: January 28, 2021
    Inventors: Makonen BELEMA, John A. BENDER, David B. FRENNESSON, Eric P. GILLIS, Christiana IWUAGWU, John F. KADOW, B. Narasimhulu NAIDU, Kyle E. PARCELLA, Kevin M. PEESE, Ramkumar RAJAMANI, Mark G. SAULNIER, Alan Xiangdong WANG, Manoj PATEL, Michael S. BOWSHER
  • Biaryl kinase inhibitors
    Patent number: 10544120
    Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: January 28, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne J. Bronson, Ling Chen, Jonathan L. Ditta, Carolyn Diane Dzierba, Prasada Rao Jalagam, Guanglin Luo, John E. Macor, Tarun Kumar Maishal, Susheel Jethanand Nara, Ramkumar Rajamani, Ramesh Kumar Sistla, Soodamani Thangavel
  • Aryl lactam kinase inhibitors
    Patent number: 10253027
    Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: April 9, 2019
    Assignees: Bristol-Myers Squibb Company, Syngene International Limited, Bristol-Myers Squibb Company
    Inventors: Richard A. Hartz, Vijay T. Ahuja, Joanne J. Bronson, Carolyn Diane Dzierba, John E. Macor, Susheel Jethanand Nara, Ramkumar Rajamani
  • Biaryl kinase inhibitors
    Patent number: 10246469
    Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 2, 2019
    Assignees: Bristol-Myers Squibb Company, Syngene International Limited, Bristol-Myers Squibb Company
    Inventors: Joanne J. Bronson, Ling Chen, Jonathan L. Ditta, Carolyn Diane Dzierba, Prasada Rao Jalagam, Guanglin Luo, John E. Macor, Tarun Kumar Maishal, Susheel Jethanand Nara, Ramkumar Rajamani, Ramesh Kumar Sistla, Soodamani Thangavel
  • BIARYL KINASE INHIBITORS
    Publication number: 20190040080
    Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
    Type: Application
    Filed: September 29, 2016
    Publication date: February 7, 2019
    Inventors: Joanne J. BRONSON, Ling CHEN, Jonathan L. DITTA, Carolyn Diane DZIERBA, Prasada Rao JALAGAM, Guanglin LUO, John E. MACOR, Tarun Kumar MAISHAL, Susheel Jethanand Nara, Ramkumar RAJAMANI, Ramesh Kumar SISTLA, Soodamani THANGAVEL
  • BIARYL KINASE INHIBITORS
    Publication number: 20180346440
    Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
    Type: Application
    Filed: September 29, 2016
    Publication date: December 6, 2018
    Inventors: Joanne J. Bronson, Ling Chen, Jonathan L. Ditta, Carolyn Diane Dzierba, Prasada Rao Jalagam, Guanglin Luo, John E. Macor, Tarun Kumar Maishal, Susheel Jethanand Nara, Ramkumar Rajamani, Ramesh Kumar Sistla, Soodamani Thangavel
  • Heterocyclic kinase inhibitors
    Patent number: 10035777
    Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: July 31, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carolyn Diane Dzierba, Joanne J. Bronson, John E. Macor, Bireshwar Dasgupta, Susheel Jethanand Nara, Vivekananda M. Vrudhula, Senliang Pan, Richard A. Hartz, Ramkumar Rajamani
  • HETEROCYCLIC KINASE INHIBITORS
    Publication number: 20170260145
    Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
    Type: Application
    Filed: July 27, 2015
    Publication date: September 14, 2017
    Inventors: Carolyn Diane Dzierba, Joanne J. Bronson, John E. Macor, Bireshwar Dasgupta, Susheel Jethanand Nara, Vivekananda M Vrudhula, Senliang Pan, Richard A. Hartz, Ramkumar Rajamani
  • Pyrrolotriazine kinase inhibitors
    Patent number: 9737542
    Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: August 22, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carolyn Diane Dzierba, Bireshwar Dasgupta, John E. Macor, Joanne J. Bronson, Ramkumar Rajamani, George N. Karageorge