Patents by Inventor Ramnarayan Randad

Ramnarayan Randad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aspartic protease inhibitors
    Publication number: 20050090546
    Abstract: The present invention provides an aspartic proteinase-inhibiting compound of the formula: wherein a, b, c, d, and e, can be the same or different and each are R7, OR7, SR7, NR7R7, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen, wherein R7 and R8 are independently H or an alkyl. Substituents R1 or R2 are each H or an alkyl. Substituent R3 is a straight chain or branched alkyl, alkenyl, or alkynyl substituent, or is a cycloalkyl. Substituent A is OH, NH2, or SH. Further provided are pharmaceutical compositions, which include a therapeutically effective amount of at least one of the foregoing compounds, and therapeutic methods of using the foregoing compounds.
    Type: Application
    Filed: June 11, 2003
    Publication date: April 28, 2005
    Applicant: Government of the USA, represented by the Secretary, Department of Health and Human Services
    Inventors: Ramnarayan Randad, John Erickson, Michael Eissenstat, Lucyna Lubkowska
  • Allosteric modifiers of hemoglobin
    Patent number: 5872282
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: February 16, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Donald J. Abraham, Gajanan Joshi, Ramnarayan Randad
  • Allosteric modifiers of hemoglobin useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood
    Patent number: 5731454
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: March 24, 1998
    Assignee: Virginia Commonwealth University
    Inventors: Donald J. Abraham, Gajanan Joshi, Ramnarayan Randad, Jayashree Panikker
  • Allosteric modifiers of hemoglobin
    Patent number: 5591892
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 7, 1997
    Assignee: Center for Innovative Technology
    Inventors: Donald J. Abraham, Gajanan Joshi, Ramnarayan Randad, Jayashree Panikker
  • Allosteric hemoglobin modifiers to decrease oxygen affinity in blood
    Patent number: 5432191
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: July 11, 1995
    Assignee: The Center for Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad, Gajanan S. Joshi, Jayashree Panikker
  • Allosteric hemoglobin modifier compounds
    Patent number: 5382680
    Abstract: Allosteric hemoglobin modifier compounds having the general structural formula: ##STR1## wherein the R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 moieties may be hydrogen, halogen or alkyl groups and may be the same or different, and wherein the R.sub.7 and R.sub.8 moieties may be hydrogen or methyl groups and may be the same or different.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: January 17, 1995
    Assignee: The Center for Innovative Technology
    Inventors: Donald J. Abraham, Ahmed Mehanna, Ramnarayan Randad
  • Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood
    Patent number: 5290803
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: March 1, 1994
    Assignee: The Center of Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad
  • Allosteric hemoglobin modifiers which decrease oxygen affinity in blood
    Patent number: 5250701
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: October 5, 1993
    Assignee: Center for Innovative Technology
    Inventors: Donald J. Abraham, Ramnarayan Randad
  • Using allosteric hemoglobin modifiers to decrease oxygen affinity in blood
    Patent number: 5248785
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: September 28, 1993
    Assignees: Virginia Commonwealth University, Center for Innovative Technology
    Inventors: Donald J. Abraham, Ramnarayan Randad
  • Allosteric hemoglobin modifiers useful for decreasing oxygen affinity and preserving oxygen carrying capability of stored blood
    Patent number: 5122539
    Abstract: Compounds of the general structural formula: ##STR1## wherein X, Y and Z may each be CH.sub.2, NH, or O, R.sub.2-6 are either hydrogen, halogen, or a substituted or unsubstituted C.sub.1, C.sub.2, or C.sub.3 alkyl group and these moieties maybe the same or different, or alkyl moieties of aliphatic or aromatic rings incorporating two of the R.sub.2-6 sites, R.sub.7-8 are hydrogen, methyl, or ethyl groups and these moieties may be the same or different, or alkyl moieties as part of an aliphatic ring connecting R.sub.7 and R.sub.8, and R.sub.9 is a hydrogen, loweralkyl such as methyl, ethyl or propyl, or a salt cation such as sodium, potassium, or ammonium are useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: June 16, 1992
    Assignee: Center for Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad
  • Allosteric hemoglobin modifiers
    Patent number: 5049695
    Abstract: Allosteric hemoglobin modifier compounds having the general formula ##STR1## wherein X and Z may be CH.sub.2, NH or O.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: September 17, 1991
    Assignees: Center for Innovative Technology, Virginia Commonwealth University
    Inventors: Donald J. Abraham, Ahmed Mehanna, Ramnarayan Randad, Mona Mahran