Patents by Inventor Ramon C. Sun

Ramon C. Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating cancer with an elevated glycogen content
    Patent number: 11712432
    Abstract: A method of treating cancer is provided. The method includes administering to a subject in need thereof an effective amount of a compound selected from the group consisting of a glycogen phosphorylase inhibitor, a glycogen synthase inhibitor, a glycogen degradation molecule, an anti-sense oligonucleotide that down-regulates glycogen synthesis, and combinations thereof, where the cancer includes elevated levels of glycogen.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: August 1, 2023
    Assignee: University of Kentucky Research Foundation
    Inventors: Matthew S. Gentry, Ramon C. Sun, Lyndsay EA Young
  • Manipulating Glycogen in Alzheimer’s Disease, Epilepsy, Traumatic Brain Injury, and ALS as a Treatment
    Publication number: 20230173037
    Abstract: A method for treating a neurodegenerative disease is provided. The method for treating a neurodegenerative disease includes administering, to a subject in need thereof, one or more of a small molecule glycogen synthase (GYS) inhibitor, an antisense oligonucleotide targeting glycogen synthase, an antibody-enzyme fusion compound targeting polyglucosan bodies (PGBs), or combinations thereof.
    Type: Application
    Filed: March 9, 2021
    Publication date: June 8, 2023
    Inventors: Matthew S. Gentry, Ramon C. Sun, Lance A. Johnson, Peter T. Nelson, Frank Gilliam
  • METHODS OF DETECTING GLYCOGEN AND POLYGLUCAN
    Publication number: 20220229026
    Abstract: Provided herein are methods of measuring glycogen and methods of diagnosing a disease. One method of measuring includes separating sugar monomers and sugar phosphates using gas-chromatography, and analyzing the monomers and phosphates using mass spectrometry. Another method of measuring includes adding an isoamylase to a sample, the isoamylase cleaving glucose chains from glycogen; applying a matrix-assisted laser desorption ionization (MALDI) ionization matrix to the sample; and analyzing the samples using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). The method of diagnosing a disease includes determining an amount and location of glycogen accumulation in a subject; and diagnosing a disease when over-accumulation of glycogen is determined.
    Type: Application
    Filed: January 20, 2022
    Publication date: July 21, 2022
    Inventors: Matthew S. Gentry, Ronald Bruntz, Ramon C. Sun
  • METHOD OF TREATING CANCER WITH AN ELEVATED GLYCOGEN CONTENT
    Publication number: 20200215031
    Abstract: A method of treating cancer is provided. The method includes administering to a subject in need thereof an effective amount of a compound selected from the group consisting of a glycogen phosphorylase inhibitor, a glycogen synthase inhibitor, a glycogen degradation molecule, an anti-sense oligonucleotide that down-regulates glycogen synthesis, and combinations thereof, where the cancer includes elevated levels of glycogen.
    Type: Application
    Filed: December 20, 2019
    Publication date: July 9, 2020
    Inventors: Matthew S. Gentry, Ramon C. Sun, Lyndsay EA Young