Abstract: A web contactor for the purposes of continuous separation of specific proteins from a mixture of proteins comprises an endless, inert, non-porous, flexible web is coated with an activated matrix material which is, in turn, bound to a plurality of ligand molecules. The ligand molecules are chosen to correspond to a desired biological molecule or class of molecules, typically a desired protein. The web is translated over a series of rolls such that it contacts a feed solution of a mixture of biological molecules in a countercurrent manner. During contact of the web and solution, the ligand molecules which are attached to the web matrix, selectively bind to the protein or other biological molecule which are to be separated from the feed solution mixture.