Abstract: The invention provides a peptide or a pharmaceutical salt thereof having a length from 14 to 50 and comprising a sequence having at least a 85% of sequence identity with respect to SEQ ID NO: 1, wherein “m”, “n”, “p”, and “q” represent integers and are selected from 0 and 1; the C-terminal end corresponds to —C(O)R4; and N-terminal end corresponds to —NHR5; the peptide optionally comprising a linker biradical “L” of formula (I) connecting an alpha carbon atom of an amino acid located at position “i” with an alpha carbon atom of an amino acid located at position “i+4” or “i+7” in the peptide sequence SEQ ID NO: 1. The present invention also provides fusion proteins and pharmaceutical compositions comprising the peptides of the invention as well as their use in therapy and, particularly, in the treatment of a disease caused by an increase or reduction in VEGF levels.

Abstract: In a method for monitoring a tracked parameter for a set of targets, a first methodology is applied during a current time interval to acquire observations of the tracked parameter for a selected sub-set of the set of targets. A second methodology is applied during the current time interval to acquire observations of the tracked parameter for at least those targets that are not in the selected sub-set of the set of targets. A variance forecast is generated for an upcoming time interval for each target based on a current variance for the target and on either observations acquired using the first methodology or using the second methodology. The selected sub-set of the set of targets is updated for the upcoming time interval to maximize an aggregation of variance forecasts over the updated selected sub-set of the set of targets.

Abstract: The child monitoring system that is composed of a portable detector that detects the passage of a child or an adult through a linear perimeter and a receiver that receives an alarm from the portable detector. The detector is programmed to transmit an alarm when the detector detects a child has passed through the linear perimeter and the detector does not detect an adult passing through the linear perimeter within a period. If the system detects that a child has passed through the linear perimeter, then the system is programmed to determine if an adult has also passed thought the linear perimeter, if no adult passes through the linear perimeter within a period, then the detector will transmit a transmission to a wireless receiver that will alarm a caregiver of the child that the child has left the secured area.

Abstract: A method and system for completing cementing operations in a subterranean well with a wiper plug assembly includes delivering the wiper plug assembly into a casing, the wiper plug assembly having a wiper plug body with a circular cross section and a resilient wiper element that engages an inner diameter of the casing string. An inclination of the wiper plug assembly is measured in three dimensions with an accelerometer assembly and an azimuth of the wiper plug assembly is measured in three dimensions with a magnetometer. The inclination and the azimuth of the wiper plug assembly are delivered to a control unit in real time. An inclination of the wiper plug assembly is determined in real time. The inclination of the wiper plug assembly is delivered to an earth's surface in real time with a transmitter of the electronics package.

Abstract: A method and system for completing cementing operations in a subterranean well with a wiper plug assembly includes delivering the wiper plug assembly into a casing, the wiper plug assembly having a wiper plug body with a circular cross section and a resilient wiper element that engages an inner diameter of the casing string. An inclination of the wiper plug assembly is measured in three dimensions with an accelerometer assembly and an azimuth of the wiper plug assembly is measured in three dimensions with a magnetometer. The inclination and the azimuth of the wiper plug assembly are delivered to a control unit in real time. An inclination of the wiper plug assembly is determined in real time. The inclination of the wiper plug assembly is delivered to an earth's surface in real time with a transmitter of the electronics package.

Abstract: The present invention relates to novel recombinant swinepox viruses and their use in vaccine compositions. The recombinant swinepox viruses of the invention encode a PCV3 antigen and may be used as vaccines.

Abstract: The present invention relates to novel recombinant swinepox viruses and their use in vaccine compositions. The recombinant swinepox viruses of the invention contain an inactive serpin gene and may be used to express any nucleic acid of interest.

Abstract: A can imprinting device includes a blanket wheel having a plurality of blankets. Each blanket has a printing surface and at least two of the printing surfaces having a first part and a second part that each have raised and recessed portions. The first raised portion is configured to form a positive image on a can body of the plurality of can bodies. The first raised portion of at least one of the blankets is different in form from the first raised portion of at least one other of the blankets. The second recessed portion is configured to form a negative image on the can body. The negative image is inverse to the positive image. The first part and the second part are disposed relative to each other such that the negative image aligns with the positive image on the can body.

Abstract: A method of automating organization of a defined space is provided. Spatial data about the defined space and location data of objects in the defined space are received from a number of input devices. A baseline organization scheme of objects in the defined space is created. User profile data is received for an organizer, and a recommended organization scheme of items in the defined space is created based on comparison of the baseline organization scheme with the user profile data for the organizer. A presentation of the recommended organization scheme is generated by a number of user interfaces. Locations of items in the defined space relative to the recommended reorganization scheme are monitored utilizing a number of sensors, and an alert is sent to the organizer if locations of items in the defined space deviate from the recommended organization scheme beyond a predefined threshold.

Abstract: Systems and methods for sealing a wellbore are described. The system includes a packing element configured to at least partially seal an uphole portion of a wellbore from a downhole portion of the wellbore. A first annular pressure sensor is positioned uphole of the packing element. The first annular pressure sensor is configured to measure a first pressure within the wellbore uphole of the packing element. A second annular pressure sensor is positioned downhole of the packing element. The second annular pressure sensor is configured to measure a second pressure within the wellbore downhole of the packing element. A control sub-assembly is configured to be positioned within the wellbore. The control sub-assembly is configured to monitor a sealing efficiency of the system by comparing the first pressure and the second pressure.

Abstract: The present disclosure relates to a pharmaceutical composition of a combination of tramadol-etoricoxib hydrochloride for the treatment of pain. The production method of the pharmaceutical composition is based on two active ingredients including granules and/or multi-particulates containing tramadol hydrochloride and granules and/or multi-particulates containing etoricoxib. The pharmaceutical composition can be contained in a mixture of powders, included in a two-layer tablet with or without a coating, or in a capsule as granulates and/or tablets with or without a coating.

Abstract: Systems and methods for sealing a wellbore are described. The system includes a packing element configured to at least partially seal an uphole portion of a wellbore from a downhole portion of the wellbore. A first annular pressure sensor is positioned uphole of the packing element. The first annular pressure sensor is configured to measure a first pressure within the wellbore uphole of the packing element. A second annular pressure sensor is positioned downhole of the packing element. The second annular pressure sensor is configured to measure a second pressure within the wellbore downhole of the packing element. A control sub-assembly is configured to be positioned within the wellbore. The control sub-assembly is configured to monitor a sealing efficiency of the system by comparing the first pressure and the second pressure.

Abstract: A first polish bore receptacle includes a first uphole end and a second downhole end. The first downhole end of the first polish bore receptacle attaches at an uphole end of a liner disposed at a downhole end of a wellbore. The first polish bore receptacle accepts a first seal assembly. A second polish bore receptacle includes a second uphole end and a second downhole end. The second polish bore receptacle is disposed uphole of the first polish bore receptacle. The second polish bore receptacle receives a second seal assembly. A retrievable ratch latch assembly connects the second downhole end of the second polish bore receptacle and the first uphole end of the first polish bore receptacle. The ratch latch assembly and the second polish bore receptacle are retrievable from within the wellbore.

Abstract: A can imprinting device includes a blanket wheel having a plurality of blankets. Each blanket has a printing surface and at least two of the printing surfaces having a first part and a second part that each have raised and recessed portions. The first raised portion is configured to form a positive image on a can body of the plurality of can bodies. The first raised portion of at least one of the blankets is different in form from the first raised portion of at least one other of the blankets. The second recessed portion is configured to form a negative image on the can body. The negative image is inverse to the positive image. The first part and the second part are disposed relative to each other such that the negative image aligns with the positive image on the can body.

Abstract: Methods, computer program products, and systems are presented. The methods include, for instance: receiving a request for a response to have a piece of annotative data on a literary text from a user; ascertaining metadata to generate the response is available for the literary device system; identifying a process of the literary device system that is associated with the request; running the process with the request and generating the response based on the metadata; and producing the response to the user such that the user is presented with the annotative data on the literary text.

Abstract: The invention provides a combination comprising thrombin, fibrinogen, and lipidated tissue factor, as well as sealant compositions comprising thereof, and their use as a sealant agent as well as in the treatment of hemorrhages. The combination and compositions of the invention shows improved hemostatic properties and, at the same time, the quality of the clot formed is so consistent that the sealant efficiency is improved over those sealant compositions of the prior art.

Abstract: The invention provides a composition comprising a combination of lipidated tissue factor and thrombin, wherein the amount of thrombin is comprised from 1 to 30 IU per gram of composition, and the amount of lipidated tissue factor is comprised from 5 to 150 ng per gram of composition. The present invention also provides pharmaceutical or veterinary compositions as well as hemostatic compositions. The compositions of the invention are useful in the treatment of hemorrhages.

Abstract: In a method for monitoring a tracked parameter for a set of targets, a first methodology is applied during a current time interval to acquire observations of the tracked parameter for a selected sub-set of the set of targets. A second methodology is applied during the current time interval to acquire observations of the tracked parameter for at least those targets that are not in the selected sub-set of the set of targets. A variance forecast is generated for an upcoming time interval for each target based on a current variance for the target and on either observations acquired using the first methodology or using the second methodology. The selected sub-set of the set of targets is updated for the upcoming time interval to maximize an aggregation of variance forecasts over the updated selected sub-set of the set of targets.

Abstract: The invention relates to a process for manufacturing flat glass rich in lead oxide, comprising the continuous floating, in a float plant with a neutral gaseous atmosphere, of a glass comprising at least 30% lead oxide by weight on a bath of molten metal having a higher density than that of the glass. The invention allows flat glass rich in lead, useful for protection against X-rays, to be produced.