Abstract: Disclosed herein are systems, apparatuses and methods for applying commercially available sutures or other wound repair devices to improve and/or accelerate healing. In an exemplified embodiment, provided are methods, apparatuses, and systems that enable intra-operative application of wound repair devices with biologic and/or pharmaceutical compositions to facilitate controlled delivery of bioactive molecules, resulting in improved musculoskeletal soft tissue repair and reconstruction. In a specific embodiment, a method including obtaining an isolated platelet rich plasma (PRP) sample, and applying the sample to a suture under conditions to provide a dry coat of PRP onto the suture is disclosed herein.

Abstract: Compositions and methods for producing encapsulated cells having an average diameter of less than about 200 ?m are provided.