Abstract: A system for TFF filtration of a feedstock includes a feed vessel containing a solution comprising a target biomolecule, a filter membrane for filtering the solution, a feed pump for moving the solution from the feed vessel to the filter membrane, a buffer vessel coupled to the feed vessel by a buffer supply line, and a diafiltration pump disposed in the buffer supply line for delivering a buffer solution to the feed vessel. A variable path-length instrument is coupled to the feed line for determining, in real time, a concentration of the target biomolecule in the solution. A controller is coupled to the variable path-length instrument, the feed pump, and the diafiltration pump to control operation of the system based on the received information.

Abstract: The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

Abstract: The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

Abstract: The present invention relates to methods for controlling chromatographic processes in real-time via mass measurement utilizing a variable pathlength spectrophotometer.

Abstract: The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy. Further, the systems and methods of the present disclosure allows the user to forgo the use of a bioanalyzer or HPLC.

Abstract: The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

Abstract: The present invention provides systems, devices, and methods to vaporize prostatic tissue having oxygenated hemoglobin. The systems, devices, and methods include a laser module configured to emit light near an absorption peak of the oxygenated hemoglobin and a delivery catheter that is optically coupled to the laser module and configured to deliver the light from the laser module to the prostatic tissue.

Abstract: Embodiments of the present invention provide improved laser systems and methods for endoscopic laser treatment of abnormal tissue such as abnormal mucosal tissue, for example esophageal dysplasia that is also referred to as Barrett's esophagus (BE). The systems and methods described here can also be used in many applications where treatment of shallow surface layers with minimal damage to the tissue beneath is desirable, for example BE tissue comprising hemoglobin. In many embodiments, the system is configured to emit light energy having an optical wavelength to treat tissue having oxygenated hemoglobin.

Abstract: The present invention is an illumination device designed to provide efficient illumination in confined spaces and methods of using such a device. The devices of the present invention comprise a laser light source of a specifically selected wavelength or wavelengths, optical fiber(s) and one or more light converters to convert the input laser light to broad spectrum white light or a specific desired wavelength. The light converter may be integral/modular with the fiber optic assembly. The light converter may be constructed of phosphors, nanocrystals or other energy converters which are embedded within a transport material such as polymer or glass.

Abstract: The present invention is an illumination device designed to provide efficient illumination in confined spaces and methods of using such a device. The devices of the present invention comprise a laser light source of a specifically selected wavelength or wavelengths, optical fiber(s) and one or more light converters to convert the input laser light to broad spectrum white light or a specific desired wavelength. The light converter may be integral/modular with the fiber optic assembly. The light converter may be constructed of phosphors, nanocrystals or other energy converters which are embedded within a transport material such as polymer or glass.