Abstract: Methods and systems for delivering gas-enriched blood within a vasculature of a patient may include providing a gas-enrichment system, the gas-enrichment system comprising a mixing chamber and a blood pump. The process may include inserting a catheter for drawing blood from the patient into a radial artery of the patient. The process may include drawing blood from the radial artery or from a vessel upstream of the radial artery at a blood flow rate without collapsing the artery or vessel to a degree that would substantially impede drawing blood. The process may include generating a gas-enriched blood by mixing the withdrawn blood with a gas-enriched liquid in a mixing chamber. The process may include delivering the gas-enriched blood to the vasculature of the patient.

Abstract: A patient-worn ambulatory cardiac monitoring device for monitoring a patient during a patient activity includes at least one physiological sensor configured to detect signals indicative of cardiac activity, an activity sensor and associated circuitry configured to monitor patient movements, and a vibrational sensor configured to monitor a cardio-vibrational signal of the patient. The at least one physiological sensor can include one of an ECG sensor and a heart rate sensor. At least one processor in communication with the at least one physiological sensor, the activity sensor, and the vibrational sensor, is configured to measure, during the patient activity, at least one time interval between an ECG fiducial point in an ECG signal and a cardio-vibrational fiducial point in the cardio-vibrational signal during a cardiac cycle of the patient’s heart.

Abstract: The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and/or one or more imaging systems may be used to measure or determine one or more physiological parameters of the patient. Feedback regarding one or more physiological parameters or microvascular resistance may be provided for titrating or controlling the gas-enrichment therapy.

Abstract: A patient-worn ambulatory cardiac monitoring device for monitoring a patient during a patient activity includes at least one physiological sensor configured to detect signals indicative of cardiac activity, an activity sensor and associated circuitry configured to monitor patient movements, and a vibrational sensor configured to monitor a cardio-vibrational signal of the patient. The at least one physiological sensor can include one of an ECG sensor and a heart rate sensor. At least one processor in communication with the at least one physiological sensor, the activity sensor, and the vibrational sensor, is configured to measure, during the patient activity, at least one time interval between an ECG fiducial point in an ECG signal and a cardio-vibrational fiducial point in the cardio-vibrational signal during a cardiac cycle of the patient's heart.

Abstract: A cardiac monitoring system for displaying contextual biometric information for arrhythmia events occurring in a patient is provided. The system includes a cardiac sensor configured to be coupled to the patient. The cardiac sensor is configured to transmit ECG signals and motion signals to a remote server. The remote server is in communication with the cardiac sensor and further in communication with a user interface. The remote server includes a database implemented in a non-transitory memory and a processor in communication with the database. The processor is configured to store the ECG signals and the motion signals in the database and identify an arrhythmia event based on the received ECG signals. The processor is also configured to determine, based on the motion signals, contextual biometric information of the patient for the arrhythmia event and display, on the user interface, the arrhythmia event with the contextual biometric information of the patient.

Abstract: A patient-worn ambulatory cardiac monitoring device for monitoring a patient during a patient activity includes at least one physiological sensor configured to detect signals indicative of cardiac activity, an activity sensor and associated circuitry configured to monitor patient movements, and a vibrational sensor configured to monitor a cardio-vibrational signal of the patient. The at least one physiological sensor can include one of an ECG sensor and a heart rate sensor. At least one processor in communication with the at least one physiological sensor, the activity sensor, and the vibrational sensor, is configured to measure, during the patient activity, at least one time interval between an ECG fiducial point in an ECG signal and a cardio-vibrational fiducial point in the cardio-vibrational signal during a cardiac cycle of the patient's heart.

Abstract: A system that activates a muscle to produce a functional movement in a subject through electrical stimulation is described. During operation, the system first obtains a non-isometric model which defines a functional movement associated with the muscle in response to electrical stimulation of the muscle. Next, the system uses the non-isometric model to compute an electrical stimulation which produces a desired functional movement in the subject. The system then applies the computed electrical stimulation to the muscle to produce the desired functional movement in the subject.

Abstract: One embodiment of the present invention provides a system that activates a muscle to produce a functional movement in a subject through electrical stimulation. During operation, the system first obtains a non isometric model which defines a functional movement associated with the muscle in response to electrical stimulation of the muscle. Next, the system uses the non isometric model to compute an electrical stimulation which produces a desired functional movement in the subject. The system then applies the computed electrical stimulation to the muscle to produce the desired functional movement in the subject.