Patents by Inventor Ramu Rondla

Ramu Rondla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantioconvergent chemoenzymatic synthesis of ()-?-amino-?-hydroxybutyric acid (()-GABOB)
    Patent number: 7374926
    Abstract: The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: May 20, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Gollapalli B. Ramesh Khanna, Krishnaji Tadiparthi, Ramu Rondla
  • Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates useful as antitumour agents
    Patent number: 7173026
    Abstract: The present invention relates to synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone hybrids (V) wherein n=3,4; R=H, OH and to their use as antitumour agents.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: February 6, 2007
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Gollapalli B. Khanna Ramesh, Ramu Rondla
  • Enantioconvergent chemoenzymatic synthesis of (R)-gamma-amino-beta-hydroxybutyric acid ((R)-GABOB)
    Publication number: 20060141606
    Abstract: The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.
    Type: Application
    Filed: December 23, 2004
    Publication date: June 29, 2006
    Applicant: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Gollapalli Khanna, Krishnaji Tadiparthi, Ramu Rondla
  • Pyrrolo [2, 1-c] [1, 4] benzodiazepine-anthraquinone conjugates useful as antitumour agents
    Publication number: 20060142272
    Abstract: The present invention relates to synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone hybrids (V) wherein n=3,4; R?H, OH and to their use as antitumour agents
    Type: Application
    Filed: December 27, 2004
    Publication date: June 29, 2006
    Applicant: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Gollapalli Khanna Ramesh, Ramu Rondla
  • Chemoenzymatic process for stereoselective preparation of and enatiomers of 2-hydroxy-3-(2-thienyl) propanenitrile
    Patent number: 7045341
    Abstract: A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates were prepared by enzymatic resolution of (±)3-hydroxy-3-(2-thienyl) propanenitrile both by transesterification and by hydrolysis reaction which were then transformed to both enantiomers of duloxetine.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: May 16, 2006
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Bhasker Ramesh Khanna Gollapalli, Ramu Rondla, Venkateswara Rao Maddamsetty
  • PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20060003994
    Abstract: The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety as potential antitumour agents. The present invention also relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety useful as potential antitumour agents.
    Type: Application
    Filed: June 30, 2004
    Publication date: January 5, 2006
    Inventors: Ahmed Kamal, Ramu Rondla, Gollpalli Khanna
  • Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof
    Patent number: 6979684
    Abstract: The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety as potential antitumour agents. The present invention also relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety useful as potential antitumour agents.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: December 27, 2005
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramu Rondla, Gollpalli Bhasker Ramesh Khanna
  • Chemoenzymatic process for stereoselective preparation of R and S enatiomers of 2-hydroxy-3-(2-thienyl) propanenitrile
    Publication number: 20040185540
    Abstract: A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates were prepared by enzymatic resolution of (+)3-hydroxy-3-(2-thienyl) propanenitrile both by transesterification and by hydrolysis reaction which were then transformed to both enantiomers of duloxetine.
    Type: Application
    Filed: March 20, 2003
    Publication date: September 23, 2004
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Ahmed Kamal, Bhasker Ramesh Khanna Gollapalli, Ramu Rondla, Venkateswara Rao Maddamsetty