Patents by Inventor Ramulu Poddutoori

Ramulu Poddutoori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Patent number: 7056913
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 6, 2006
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Kumar Pogula
  • PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS
    Publication number: 20050222133
    Abstract: Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as DNA sequence selective agents which are useful as potential antitumour agents. In particular, the present invention relates to a process for the preparation of new pyrrolo [2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Inventors: Ahmed Kamal, Ramulu Poddutoori, Srinivas Olepu
  • C8 - linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Publication number: 20050222132
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Pogula
  • Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids
    Patent number: 6951853
    Abstract: Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as DNA sequence selective agents which are useful as potential antitumour agents. In particular, the present invention relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 4, 2005
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramulu Poddutoori, Srinivas Olepu
  • Pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids useful as anti-cancer agents
    Patent number: 6800622
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, anticancer (antitumour) activity.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: October 5, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • PYRENE-LINKED PYRROLO[2,1--C][1,4]BENZODIAZEPINE HYBRIDS USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20040192677
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1 -c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1 -c][1,4]benzodiazepin-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, aticancer (antitumour) activity.
    Type: Application
    Filed: March 25, 2003
    Publication date: September 30, 2004
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • Process for the preparation of antitumor agents
    Patent number: 6362331
    Abstract: The present invention provides a process for the preparation of a novel pyrrolo[2,1-c][1,4]benzodiazepine of formula VI wherein R is H, OII, OAc and R1 is H, and n is 3 to 5, by reacting (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzyl]-pyrrolidine-2-carboxy-carbaldehyde diethyl thioacetal with a dibromoalkane, isolating (2S)-N-[4-(3-bromoalkoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxy carbaldehyde diethyl thioacetal so formed and reacting the isolate with a dilactam, isolating 8-{[(2S)-N-5-methoxy-2-nitrobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal}-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11 dione, reducing the above nitro compound, isolating the 8-{[(2S)-N-5-methoxy-2-aminobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal]-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione, reacting the ami
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: March 26, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Chakravarthy Laxman Nallan, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu