Patents by Inventor Ramunas Bigelis

Ramunas Bigelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Progesterone receptor modulator and uses thereof
    Publication number: 20080306131
    Abstract: Compounds of the structure: are provided. Also provided are methods of using these compounds as progesterone receptor modulators. Also described are methods of producing these compounds from a Verticillium species.
    Type: Application
    Filed: June 2, 2008
    Publication date: December 11, 2008
    Applicant: Wyeth
    Inventors: Laurel Rita Barbieri, Thomas Joseph Berrodin, Ramunas Bigelis, Li-Ping Chang, Deborah Marie Roll, Maya Prakash Singh, Matthew R. Yudt
  • Antibiotic Cyan426-A
    Patent number: 7129266
    Abstract: The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: October 31, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yang, Ramunas Bigelis
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B
    Patent number: 7078556
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: July 18, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • ANTIBIOTICS CYAN-416 A, CYAN-416 B, CYAN-416 C, CYAN-416 D AND CYAN-416 E, AND ESTER DERIVATIVES OF CYAN-416 B
    Publication number: 20060100277
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Application
    Filed: December 16, 2005
    Publication date: May 11, 2006
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B
    Patent number: 7022873
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: April 4, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D, and Cyan-416 E, and ester derivatives of Cyan-416 B
    Publication number: 20040132812
    Abstract: The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
    Type: Application
    Filed: December 15, 2003
    Publication date: July 8, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Ramunas Bigelis
  • Antibiotic Cyan426-A
    Publication number: 20040127540
    Abstract: The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
    Type: Application
    Filed: December 15, 2003
    Publication date: July 1, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Haiyin He, Hui Yang, Ramunas Bigelis
  • Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihydroxyphenylacetic acid
    Patent number: 4956279
    Abstract: Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: September 11, 1990
    Assignee: Miles Inc.
    Inventors: Ramunas Bigelis, Kathleen A. Black
  • Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihydroxyphenylacetic acid followed by polymerization to melanin pigments
    Patent number: 4877728
    Abstract: Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain which is unable to grow on L-tyrosine and/or L-phenylalanine as the sole carbon source in a suitable growth medium containing L-tyrosine and/or L-phenylalanine together with a sub-optimal concentration of carbohydrate assimilable by the yeast. The yeast secretes recoverable quantities of homogentisic acid which can be rapidly and completely polymerized by raising the pH of the medium to above 10 thereby forming a melanin pigment.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: October 31, 1989
    Assignee: Miles Inc.
    Inventors: Ramunas Bigelis, Kathleen A. Black