Patents by Inventor Ramy A. Mahmoud
Ramy A. Mahmoud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230285278Abstract: A method of delivering a substance, such as fluticasone propionate, a nasal steroid and/or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of sinus and/or nasal inflammatory diseases, for example, chronic rhinosinusitis with or without nasal polyps, to reduce sinus inflammation, reduce sinus opacification, and/or improve associated symptoms.Type: ApplicationFiled: March 6, 2023Publication date: September 14, 2023Inventors: Ramy MAHMOUD, John MESSINA
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Patent number: 11730904Abstract: A delivery device for and method of modulating a condition relating to social cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: GrantFiled: June 4, 2021Date of Patent: August 22, 2023Assignee: OptiNose, Inc.Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20230166061Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: December 12, 2022Publication date: June 1, 2023Inventors: Per Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
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Patent number: 11554229Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: GrantFiled: June 25, 2014Date of Patent: January 17, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, John Messina
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Publication number: 20220152324Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject: a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.Type: ApplicationFiled: July 2, 2021Publication date: May 19, 2022Inventors: Per Gisle DJUPESLAND, Joseph GORDON, Michael LECLERC, Ramy A. MAHMOUD, Shane SIWINSKI
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Publication number: 20210322690Abstract: A delivery device for and method of modulating a condition relating to social cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: ApplicationFiled: June 4, 2021Publication date: October 21, 2021Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A. Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20210290867Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject, a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: ApplicationFiled: May 11, 2021Publication date: September 23, 2021Inventors: Per Gisle DJUPESLAND, Michael LECLERC, Ramy A. MAHMOUD, Shane SIWINSKI, Joseph GORDON, Justin FISK
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Patent number: 11052204Abstract: A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: GrantFiled: November 19, 2015Date of Patent: July 6, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Patent number: 11033696Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: GrantFiled: October 12, 2018Date of Patent: June 15, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Publication number: 20190290863Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: ApplicationFiled: October 12, 2018Publication date: September 26, 2019Inventors: Per Gisle Djupesland, Michael Leclerc, Ramy A. Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Patent number: 10300229Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: GrantFiled: February 25, 2013Date of Patent: May 28, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Michael Leclerc, Ramy A. Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Publication number: 20190083722Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.Type: ApplicationFiled: August 14, 2018Publication date: March 21, 2019Inventors: Per Gisle DJUPESLAND, Joseph Gordon, Michael Leclerc, Ramy A. Mahmoud, Shane Siwinski
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Patent number: 10179216Abstract: A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.Type: GrantFiled: February 25, 2013Date of Patent: January 15, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Kate Dudgeon, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A Mahmoud
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Patent number: 10076614Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.Type: GrantFiled: February 25, 2013Date of Patent: September 18, 2018Assignee: OptiNose ASInventors: Per Gisle Djupesland, Joseph Gordon, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski
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Publication number: 20160367774Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: July 1, 2016Publication date: December 22, 2016Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, John Messina
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Publication number: 20160310683Abstract: A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: ApplicationFiled: November 19, 2015Publication date: October 27, 2016Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20150246194Abstract: A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.Type: ApplicationFiled: February 25, 2013Publication date: September 3, 2015Inventors: Gisle Per Djupesland, Kate Dudgeon, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A. Mahmoud
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Publication number: 20150144129Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: June 25, 2014Publication date: May 28, 2015Inventors: Per Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
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Publication number: 20150053201Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: March 26, 2014Publication date: February 26, 2015Applicant: OPTINOSE ASInventors: Per Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
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Patent number: D725769Type: GrantFiled: May 23, 2013Date of Patent: March 31, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Kate Dudgeon, Justin Fisk, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski