Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Training neural networks by constructing a neural network model having neurons each associated with a quantized activation function adapted to output a quantized activation value. The neurons are arranged in layers and connected by connections associated quantized connection weight functions adapted to output quantized connection weight values. During a training process a plurality of weight gradients are calculated during backpropagation sub-processes by computing neuron gradients, each of an output of a respective the quantized activation function in one layer with respect to an input of the respective quantized activation function. Each neuron gradient is calculated such that when an absolute value of the input is smaller than a positive constant threshold value, the respective neuron gradient is set as a positive constant output value and when the absolute value of the input is smaller than the positive constant threshold value the neuron gradient is set to zero.

Abstract: In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit CTGF expression and are therefore useful for treating idiopathic pulmonary fibrosis.

Abstract: The present disclosure includes, in one embodiment, a tensioner instrument having a body having a channel and a plurality of arms projecting outward from the body, each arm including a cleat having a slot adapted to receive a suture; a base member positioned within the channel of the body; an actuating mechanism having a first coupling member adapted to engage a second coupling member on the body to removeably couple the actuating mechanism to the body; and a universal joint adapted to allow for relative movement between the base member and the body such that, when each suture is positioned within each cleat and the actuating mechanism is actuated, the tensioner applies uniform tension to each suture positioned in each cleat.

Abstract: Methods, computing systems and computer program products implement embodiments of the present invention that include defining multiple capabilities for a set of resources, the resources comprising storage space. A plurality of services are defined, each of the services including one or more of the capabilities for a subset of the resources, and a software defined storage (SDS) system is configured including the defined services. Upon the SDS system receiving a request to forecast an amount of the storage space including one or more of the capabilities that will be available at a specified future time, one or more of the services including the one or more capabilities are identified, and a predicted amount of the storage space for the identified one or more services is computed for specified future time. In some embodiments, a given identified given service includes one or more additional capabilities not required by the request.

Abstract: A method of extracting gas from a tectonically-deformed coal seam in-situ by depressurizing a horizontal well cavity is provided. A horizontal well drilling and reaming subsystem constructs a U-shaped well in which a horizontal well adjoins a vertical well, and performs a reaming process on a horizontal section of the horizontal well to enlarge a hole diameter. A horizontal well hole-collapse cavity-construction depressurization excitation subsystem performs pressure-pulse excitation and stress release on the horizontal well of tectonically-deformed coal bed methane, and hydraulically displaces a coal-liquid-gas mixture such that the mixture is conveyed towards a vertical well section along a depressurizing space. A product lifting subsystem pulverizes the coal and lifts the mixture towards a wellhead of a vertical well. A gas-liquid-solid separation subsystem separates the coal, liquid and gas.

Abstract: A device for drug injection has a cartridge, which in turn has a reservoir and a fluid path. The fluid path carries a fluid for injection from the reservoir to the place where the patient is to be injected. The fluid path comprises a needle, and the fluid path is kept sterile. A drive chain extends the needle to the injection point, but is only mechanically connected to the fluid path to operate the needle, the mechanical connection being such as to operate the needle while maintaining the fluid path sterility.

Abstract: An electronic device providing image data processing and an image data processing method are provided. The electronic device comprises: a display; a reception unit for receiving an input image; and a processor which determines image characteristics of the input image, overlaps a pixel of the input image and a pixel of the display, creates a plurality of resampled images by changing the phase of the pixel of the input image on the basis of the characteristics of the display pixel, performs filtering on each of the plurality of resampled images on the basis of the characteristics of the image, and renders a corrected image on the display by creating the corrected image on the basis of the plurality of resampled images.

Abstract: The present specification discloses a smart broadcast device, including: a device body, wherein the device body comprises a first surface that comprises a payment graphic code; a transceiver, installed inside the device body and configured to communicate with a payment service provider through maintaining a persistent wireless and/or wired network connection with the payment service provider; a processor, installed inside the device body and electrically connected to the transceiver; and a speaker, installed inside the device body and electrically connected to the processor, wherein the processor submits a payment result audio signal to the speaker upon receiving an external trigger signal from the payment service provider by using the transceiver, wherein the external trigger signal includes data defining at least a portion of a payment result, and wherein the payment result audio signal drives the speaker to output payment result audio.

Abstract: A method includes processing an input comprising data from an intraoral image using a trained machine learning model that has been trained to classify regions of dental sites, wherein the trained machine learning model outputs a probability map comprising, for each pixel in the intraoral image, a first probability that the pixel belongs to a first dental class and a second probability that the pixel belongs to a second dental class, wherein the first dental class represents excess material, the excess material comprising material other than teeth or gums. The method further includes determining, based on the probability map, one or more pixels in the intraoral image that are classified as excess material. The method further includes hiding or removing from the intraoral image data for the one or more pixels that are classified as excess material.

Abstract: A spin coating device and method. The spin coating device includes a rotatable rotary shaft and sucker fixed on an end portion of the shaft, and an electromagnetic induction device below the sucker which includes an annular magnet fixed below the sucker, coil group formed by a first and second coil, and strip-shaped magnet fixed at the rotary shaft. A base on the sucker has a notch. The unbalanced centrifugal force during rotation of the sucker causes vibration. The electromagnetic induction device enables the centrifugal force generated during rotation of the sucker to be in balance with the magnetic force generated by the electromagnetic induction device to adjust the levelness of the sucker surface. The device does not need manual manipulation, enables the sucker to be more stable, reduces damage to the equipment due to vibration, and improves the effect of photoresist spin-coating while saving time and labor.

Abstract: An integrated circuit device is provided as follows. A fin-type active region extends on a substrate in a first horizontal direction. A gate line extends on the fin-type active region in a second horizontal direction intersecting the first horizontal direction. A source/drain region is disposed in the fin-type active region at one side of the gale line. An insulating cover extends parallel to the substrate with the gate line and the source/drain region arranged between the insulating cover and the substrate. A source/drain contact that vertically extends through the insulating cover has a first sidewall covered with the insulating cover and an end connected to the source/drain region. A fin isolation insulating unit vertically extends through the insulating cover into the fin-type active region. The source/drain region is arranged between the fin isolation insulating unit and the gate line.

Abstract: A method for monitoring acceleration of a number A of axes of a multi-axis kinematic system utilizes a sampling process with a first sampling interval, wherein a first acceleration limit value assigned to the first sampling interval and a second different acceleration limit value is determined for the acceleration, where a second time interval is assigned to the second acceleration limit value, a plurality of position values of the axis is determined by sampling with the first sampling interval, a current acceleration is calculated via the ascertained position values, and the calculated current acceleration is monitored via a first instance of monitoring utilizing the first acceleration limit value and the assigned first sampling interval and, simultaneously, via a second instance of monitoring utilizing the second acceleration limit value and the assigned second time interval, such that acceleration of an axis is monitored using at least two acceleration limit values simultaneously.

Abstract: Disclosed are a hybrid vehicle torque adjusting method and device. The method includes: acquiring a requested torque of a front-axle engine and a requested torque of a rear-axle motor, determining a first compensation torque according to the filtered requested torque of the front-axle engine and an actual output torque of a front-axle transmission, and determining a target torque of the rear-axle motor according to the first compensation torque and the requested torque of the rear-axle motor. In the method, since a difference exists between the filtered requested torque of the front-axle engine and the actual output torque of the front-axle transmission during shifting of the front-axle transmission, after the difference is compensated by the rear-axle motor, a working condition that affects a dynamic performance of an entire vehicle can be eliminated, torques can be coordinated, and the dynamic performance of the entire vehicle can be improved.

Abstract: The invention discloses a method for simulating the discontinuity of the hydraulic fracture wall in fractured reservoirs, comprising the following steps: establish a physical model of the natural fracture; establish a hydraulic fracture propagation calculation equation; establish a natural fracture failure model, calculate the natural fracture aperture, and then calculate the natural fracture permeability, and finally convert the natural fracture permeability into the permeability of the porous medium; couple the hydraulic fracture propagation calculation equation with the permeability of the porous medium through the fracture propagation criterion and the fluid loss to obtain a pore elastic model of the coupled natural fracture considering the influence of the natural fracture; work out the stress and displacement distribution of the hydraulic fracture wall with the pore elastic model of the coupled natural fracture, and analyze the offset and discontinuity of the hydraulic fracture wall according to the dis

Abstract: The present invention relates to a composition for surface modification. The composition for surface modification according to the present invention contains a particular carbodiimide-based compound, thus forms a covalent bond without damaging skin, hair, or fabric, and semipermanently provides desired skin or hair surface modification effects or fabric care effects.

Abstract: A device and a method for controlling a device using a real-time image are provided. The method includes: receiving an image captured by an image capturing device connected to a network to display the image in real-time; searching for the device that is connected to the network and is controllable; designating, within the image, a setting zone corresponding to the device; receiving a user input; and controlling the device selected according to the user input. A location of the setting zone within the image may be updated according to a change in the image. The user may receive immediate visual feedback on how the devices are being controlled. The user may control a device displayed on the screen on which the real-time indoor image is displayed without having to navigate through different sub-menus for different devices.

Abstract: A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.

Abstract: Disclosed are a crystal form of an indole derivative (compound 1) and a pharmaceutical composition and preparation method thereof. The crystal form is used to prepare a drug for treating a disease related to a CRTH2 receptor.

Abstract: A semiconductor photoresist composition includes an organometallic compound represented by Chemical Formula 1, an organometallic compound represented by Chemical Formula 2, and a solvent, and a method of forming patterns using the same. When the semiconductor photoresist composition is irradiated with e.g., extreme ultraviolet light, radical crosslinking between Sn-containing units may occur via Sn—O—Sn bond formation, and a photoresist polymer providing excellent sensitivity, small or reduced line edge roughness, and/or excellent resolution may be formed.