Patents by Inventor Ran BROSH, SR.

Ran BROSH, SR. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for F-box hormone receptor regulated protein expression in mammalian cells
    Patent number: 11078496
    Abstract: The present invention relates to a system for F-box hormone receptor regulated protein expression in mammalian cells. The system includes a silencing nucleic acid molecule comprising a first promoter and an shRNA operably linked to the first promoter, where the shRNA silences expression of a target protein. The system also includes an expression nucleic acid molecule comprising a second promoter, an F-box hormone receptor operably linked to the second promoter, and a nucleic acid molecule encoding a fusion protein comprising a degron fused to the target protein, where the nucleic acid molecule encoding the fusion protein is operably linked to the second promoter. Also disclosed are vectors comprising the system of the present application and methods of use thereof.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 3, 2021
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Ran Brosh, Sr., Ihor R. Lemischka, Ning Zheng
  • SYSTEM FOR F-BOX HORMONE RECEPTOR REGULATED PROTEIN EXPRESSION IN MAMMALIAN CELLS
    Publication number: 20190316150
    Abstract: The present invention relates to a system for F-box hormone receptor regulated protein expression in mammalian cells. The system includes a silencing nucleic acid molecule comprising a first promoter and an shRNA operably linked to the first promoter, where the shRNA silences expression of a target protein. The system also includes an expression nucleic acid molecule comprising a second promoter, an F-box hormone receptor operably linked to the second promoter, and a nucleic acid molecule encoding a fusion protein comprising a degron fused to the target protein, where the nucleic acid molecule encoding the fusion protein is operably linked to the second promoter. Also disclosed are vectors comprising the system of the present application and methods of use thereof.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 17, 2019
    Inventors: Ran BROSH, SR., Ihor R. LEMISCHKA, Ning ZHENG