Abstract: Provided herein are T cell receptors (TCRs) or antigen-binding fragments thereof, such as those that recognize or bind a relatively hematopoietically-restricted minor histocompatibility antigen, e.g., HA-2. In particular, the present disclosure relates to TCRs that bind or recognize particular HA-2 peptides in the context of a major histocompatibility complex (MHC) molecule. The present disclosure further relates to nucleic acids encoding such TCRs, engineered cells comprising such TCRs, methods of isolating such TCRs, and uses thereof, for example, in cell therapy.

Abstract: The technology described herein is directed to improved methods of T cell differentiation. Also described herein are immune cells differentiated using such methods and compositions comprising such immune cells. In some embodiments, the immune cells can be genetically modified. In some embodiments, the immune cells or compositions comprising said immune cells can be administered to a patient as a cellular replacement therapy to treat a condition.

Abstract: Provided are a high-plasticity dual-phase high-entropy alloy (HEA) and a preparation method thereof. The high-plasticity dual-phase HEA has a chemical formula as shown in Formula I: (FeCoNiCr)100-xTix (Formula I), in which, x is in a range of 2.0 to 2.8. A method for preparing the high-plasticity dual-phase HEA is also provided.

Abstract: The present disclosure provides a high-entropy alloy (HEA) with room-temperature superplasticity and a preparation method thereof, belonging to the field of metal materials. In the present disclosure, the HEA with room-temperature superplasticity has a chemical formula shown in Formula I: (FeCoNiCr)100-xCux (Formula I), where in Formula I, x is 2.0 to 4.0. A FeCoNiCr alloy is used as a matrix, and then added with a trace amount of a Cu element, thereby significantly reducing formation of a metastable phase in the FeCoNiCr alloy while reducing stacking fault energy of the alloy, such that the alloy maintains a desirable work hardening ability and achieves an excellent elongation at break. Moreover, a plasticity of the alloy is further improved through twinning-induced plasticity (TWIP).

Abstract: The technology described herein is directed to stromal-free methods of NK cell differentiation. Also described herein are cells differentiated using stromal-free methods and compositions comprising such cells. In some embodiments, the cells can be genetically modified. In some embodiments, the cells or compositions comprising said cells can be administered to a patient to treat cancer or as a cellular replacement therapy to treat a condition.

Abstract: The technology described herein is directed to stromal-free methods of T cell differentiation. Also described herein are immune cells differentiated using stromal-free methods and compositions comprising such immune cells. In some embodiments, the immune cells can be genetically modified. In some embodiments, the immune cells or compositions comprising said immune cells can be administered to a patient as a cellular replacement therapy to treat a condition.

Abstract: Embodiments of this application disclose an interaction information obtaining method performed at a target user terminal. After detecting, on a virtual map preset in an interaction application, a trigger operation performed on a target POI identifier, the target user terminal obtains first location information of the target user terminal by using the virtual map and second location information corresponding to the target POI identifier on the virtual map. The target user terminal detects a distance difference between the first location information and the second location information. When the distance difference satisfies a preset distance range, the target user terminal sends, to an interaction server, an interaction information request carrying the target POI identifier and receives interaction information corresponding to the target POI identifier from the interaction server and then displays the interaction information on the virtual map.

Abstract: Embodiments of this application disclose an interaction information obtaining method performed at a target user terminal. After detecting, on a virtual map preset in an interaction application, a trigger operation performed on a target POI identifier, the target user terminal obtains first location information of the target user terminal by using the virtual map and second location information corresponding to the target POI identifier on the virtual map. The target user terminal detects a distance difference between the first location information and the second location information. When the distance difference satisfies a preset distance range, the target user terminal sends, to an interaction server, an interaction information request carrying the target POI identifier and receives interaction information corresponding to the target POI identifier from the interaction server and then displays the interaction information on the virtual map.