Abstract: A braking system for an air brake vehicle includes a source of working pressure and a source of vacuum pressure. The system includes at least one brake actuator having a first chamber for receiving the working pressure, a second chamber for receiving the vacuum pressure; and a push rod that moves linearly in response to pressure in the first chamber and second chamber. A brake assembly is mechanically connected to the push rod for applying friction to a wheel end of a vehicle in response to the linear movement of the push rod.

Abstract: A system for calibrating signals received over a power line within a vehicle includes a signal conditioning circuit that converts the analog input signals into digital input signals. In one embodiment the circuit includes an adjustable gain circuit that outputs an amplifier gain signal establishing an amplifier gain level and an amplifier that outputs amplified signals responsive to the analog input signals and the amplifier gain signal. In another embodiment, the circuit includes a bias circuit that outputs a bias signal establishing a bias level and a comparator that generates the digital input signals responsive to the analog input signals and the bias signal. A controller receives the digital input signals and generates, depending on the embodiment, one or more control signals configured to control the configuration of the amplifier gain signal and amplifier gain level and/or the bias signal and the bias level.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: A system for calibrating signals received over a power line within a vehicle includes a signal conditioning circuit that converts the analog input signals into digital input signals. In one embodiment the circuit includes an adjustable gain circuit that outputs an amplifier gain signal establishing an amplifier gain level and an amplifier that outputs amplified signals responsive to the analog input signals and the amplifier gain signal. In another embodiment, the circuit includes a bias circuit that outputs a bias signal establishing a bias level and a comparator that generates the digital input signals responsive to the analog input signals and the bias signal. A controller receives the digital input signals and generates, depending on the embodiment, one or more control signals configured to control the configuration of the amplifier gain signal and amplifier gain level and/or the bias signal and the bias level.

Abstract: A system for predicting therapy resistance and its molecular mechanisms in rectal cancer before treatment is provided. The system includes a feature extraction device, a collection device, a signature construction device and a prediction device. The system can predict responses to neoadjuvant therapy in patients before treatment, analyze patients who are resistant to rectal cancer therapy and their underlying molecular mechanism, thereby enabling personalized therapy for patients who are resistant to rectal cancer therapy. The system has important clinical significance in improving the overall survival of rectal cancer patients.

Abstract: In an example, an energy harvesting system includes a support apparatus and a piezoelectric element. The piezoelectric element may be configured as a plate supported at its periphery by the support apparatus to enable a central portion of the piezoelectric element to move along an axis that is orthogonal to a contact surface of the plate. A body having a mass is configured to move in a direction that is substantially parallel to the axis of the plate and apply force to deform the contact surface of the plate, such that electrical energy is generated by the piezoelectric element based on the applied force.

Abstract: The present disclosure provides a microbead and a method for preparing the same. Also provided is a method for detecting and analyzing biomolecules in sample by using element analysis.

Abstract: A system includes a rectifier having an input configured to receive a variable AC input voltage and convert the AC input voltage to a rectified output voltage. A power converter has an input coupled to receive the rectified output voltage and to provide a DC supply voltage at an output thereof. A low drop-out regulator has an input coupled to receive the supply voltage and is configured provide a regulated voltage. A sensor is coupled to receive the regulated voltage as a power source and is configured to sense a condition and provide sensor data indicative of the sensed condition.

Abstract: Provided is a tag for labeling a biomolecule, comprising a polymer backbone, one or more pendant moieties, and an end group capable of binding to the biomolecule, wherein each of the pendant moieties is attached to the polymer backbone and capable of chelating with an element. Also provided is a conjugate, comprising a biomolecule covalently coupled with the tag.

Abstract: Systems and methods are provided for high-efficiency transport of single particles for inductively coupled plasma mass spectrometry. Single particles may be delivered to the mass spectrometer for quantification of trace elements. The systems may include droplet generation, conveyance module, capillary tubing, and/or an integrated inductively coupled plasma (ICP) torch, which may allow for the sequential transportation of single particles.

Abstract: Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETA receptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof.

Abstract: A sensor network that is easy to deploy and substantially maintenance-free is disclosed. Sensor networks in accordance with the present invention include a base station and at least one sensor node that is operative for monitoring the occupancy of an area and wirelessly communicating information to the base station. The sensor node includes an energy harvester for converting ambient energy into electrical energy and an energy manager that enables self-powering of the sensor node using only the electrical energy derived from the ambient energy. The energy manager also includes a cold-start module that enables initiation of sensor-node operation even in the absence of any stored energy onboard the sensor node.

Abstract: A system includes a rectifier having an input configured to receive a variable AC input voltage and convert the AC input voltage to a rectified output voltage. A power converter has an input coupled to receive the rectified output voltage and to provide a DC supply voltage at an output thereof. A low drop-out regulator has an input coupled to receive the supply voltage and is configured provide a regulated voltage. A sensor is coupled to receive the regulated voltage as a power source and is configured to sense a condition and provide sensor data indicative of the sensed condition.

Abstract: A particle implanter capable of rapidly switching implant needles is provided, which comprises an inner needle, an outer needle, a stop block A, a connecting rod, a particle library receiving device, a stop block B, a guide rod A, a guide rod B, a slide block, a connecting sleeve, a push block, a handle, a set screw, a positioning screw, a pistol grip, a spring, a positioning shaft, a switch button, a guide sleeve, an implant needle hole and a conical surface. In a switching state, pressing a switching button can gradually reduce a frictional force between a front end of the switching button and the implant needle along an axis the implant needle to zero, thereby rapidly switching the implant needle.

Abstract: This application discloses a reply information obtaining method and apparatus. The method includes: determining a target keyword corresponding to target question information according to the target question information obtained by a client; determining, according to the target keyword, a target information topic to which the target question information belongs in a plurality of information topics; and obtaining target reply information corresponding to the target question information from a target information group in a plurality of information groups, the target information group including a plurality of pairs of question information and reply information that correspond to each other, and the question information included in the target information group belonging to the target information topic. This application resolves a technical problem of relatively low efficiency of obtaining the reply information in the related art.

Abstract: In an example, an energy harvesting system includes a support apparatus and a piezoelectric element. The piezoelectric element may be configured as a plate supported at its periphery by the support apparatus to enable a central portion of the piezoelectric element to move along an axis that is orthogonal to a contact surface of the plate. A body having a mass is configured to move in a direction that is substantially parallel to the axis of the plate and apply force to deform the contact surface of the plate, such that electrical energy is generated by the piezoelectric element based on the applied force.

Abstract: Disclosed are a series of pyrimidine sulfamide compounds and applications thereof in preparing a drug for a disease related to an ETA receptor antagonist. In particular, disclosed is a derived compound represented by formula (I) or a tautomer or pharmaceutically acceptable composition thereof.

Abstract: Provided is a handcart circuit breaker and a contact device thereof including a contact arm and a moving contact. Inner walls of a cylindrical contact finger base in axial direction respectively have a contact finger groove with a spring contact finger for plugging the contact arm and a fixed contact; a rear of the contact finger base sleeves with a front of the contact arm having a positioning groove larger than a fitting end of the support pin, the contact finger base has support pins extending into the contact finger base; a diameter of a circle corresponding to the fitting end of each support pin is larger than a diameter of a circle corresponding to a bottom of each positioning groove; the contact finger base connects with the contact arm and an elastic support structure is arranged between the contact arm and the inner wall of the contact finger base.

Abstract: Disclosed is a home service robot, comprising an intelligent control system, a mechanical structure and a remote control terminal. The intelligent control system is mounted in the mechanical structure, and the intelligent control system is controlled by the remote control terminal, to cause the mechanical structure to act correspondingly. The mechanical structure comprises a head (1), a body (2), a chassis (7), a chassis suspension protection and movement mechanism and two movable moving-wing mechanisms (4). The head (1) is mounted at an upper end of the body (2), and the body (2) is mounted on the chassis (7); the two moving-wing mechanisms (4) are symmetrically mounted on two sides of the body (2), and the chassis suspension protection and movement mechanism is mounted on the bottom of the chassis (7). The robot has multiple functions.

Abstract: A sensor network that is easy to deploy and substantially maintenance-free is disclosed. Sensor networks in accordance with the present invention include a base station and at least one sensor node that is operative for monitoring the occupancy of an area and wirelessly communicating information to the base station. The sensor node includes an energy harvester for converting ambient energy into electrical energy and an energy manager that enables self-powering of the sensor node using only the electrical energy derived from the ambient energy. The energy manager also includes a cold-start module that enables initiation of sensor-node operation even in the absence of any stored energy onboard the sensor node.