Abstract: A shift-register unit, a grid driving circuit and a displaying device, which relates to the technical field of displaying. In the present disclosure, the oxide-semiconductor layers of the oxide thin-film transistors may be delimited into regions according to the total channel widths and the channel lengths required by the oxide thin-film transistors in the shift-register unit, wherein the sum of the widths of the independent semiconductor branches obtained by the delimitation is equal to the required total channel width. Accordingly, one oxide thin-film transistor can realize the required total channel width by using the one or more semiconductor branches, to ensure the normal operation of the oxide thin-film transistor, whereby the oxide-semiconductor layers of the different oxide thin-film transistors can be configured differently, to realize the purpose of reducing the border frame of the displaying device.

Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8).

Abstract: The present disclosure discloses a harmonic reducer with conjugate cycloidal profiles, including a circular spline, a flexspline, a wave generator and a flexible bearing. A profile of the circular spline and a profile of the flexspline are conjugate cycloidal profiles. The profile of the circular spline and the profile of the flexspline are formed by hypocycloids and epicycloids formed by two rolling circles around a pitch circle of the circular spline and a pitch circle of the flexspline under an engaging state respectively. A sum of radii of the first rolling circle and the second rolling circle is equal to a difference between radii of the pitch circle of the circular spline and the pitch circle of the flexspline under the engaging state. The wave generator is a biarc cam wave generator, a cam curve is an arc within an angle of contact in the long axis direction.

Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8). The magnetic nano-drug according to the present disclosure can position a VEGF ligand through magnetic targeting of hollow zinc ferrite particles, use magnetic particles to regulate reprogramming of macrophages in an intervertebral disc so as to indirectly regulate down-regulation of the VEGF, and inhibit angiogenesis.

Abstract: The present disclosure discloses a harmonic reducer with conjugate cycloidal profiles, including a circular spline, a flexspline, a wave generator and a flexible bearing. A profile of the circular spline and a profile of the flexspline are conjugate cycloidal profiles. The profile of the circular spline and the profile of the flexspline are formed by hypocycloids and epicycloids formed by two rolling circles around a pitch circle of the circular spline and a pitch circle of the flexspline under an engaging state respectively. A sum of radii of the first rolling circle and the second rolling circle is equal to a difference between radii of the pitch circle of the circular spline and the pitch circle of the flexspline under the engaging state. The wave generator is a biarc cam wave generator, a cam curve is an arc within an angle of contact in the long axis direction.

Abstract: An indazole hydrazide compound, as represented in formula (I); wherein, R is selected from substituted alkyl, substituted alkenyl and substituted phenyl; substituent in the substituted alkyl and substituted alkenyl includes phenyl and/or substituted phenyl; R? is selected from H and alkyl. Compared with the prior art, the above indole hydrazide compound can be used as integrin av?3 receptor antagonist. Besides, it has obvious anti-prostate cancer activity and has a significant inhibitory effect on enzalutamide-resistant cell lines. In addition, the above-mentioned compound has obvious anti-tumor angiogenesis activity and can be used in the preparation of anti-tumor angiogenesis drugs to inhibit tumor angiogenesis.

Abstract: Systems and methods are disclosed for implementing dual textual/graphical programming interfaces for programming streaming data processing pipelines. A user interface is provided that enables a user to author a processing pipeline as a query in a query language, and to request conversion of that query language into a graph data structure representation of the pipeline, which can be visualized in the interface. The interface further enables modification of the graph via interaction with the visualization. On request, the modified graph can be converted back into the query language, with the querying being modified to reflect the modifications to the graph.

Abstract: The attention recognition embodied by the method for evaluating the concentration ability of a sensory assessor is organically combined with evaluations for three categories of ranking capability, namely, excellent, good, and poor. Therefore, sensory assessors displaying high sensibility and poor attention form part of the group possessing excellent ranking capability, while sensory assessors exhibiting moderate sensibility and high attention can be found in the group possessing good ranking capability. Furthermore, sensory assessors displaying fair sensibility and high attention can be found in the group with poor ranking capability. This system can identify the concentration ability of assessors, therefore, providing support for the reliability of ranking results.

Abstract: Systems and methods are disclosed for implementing dual textual/graphical programming interfaces for programming streaming data processing pipelines. A user interface is provided that enables a user to author a processing pipeline as a query in a query language, and to request conversion of that query language into a graph data structure representation of the pipeline, which can be visualized in the interface. The interface further enables modification of the graph via interaction with the visualization. On request, the modified graph can be converted back into the query language, with the querying being modified to reflect the modifications to the graph. In some embodiments, the graph data structure representation and/or the query language representation of the pipeline can be converted into a third representation, such as an Abstract Syntax Tree, that is deployed to an intake system to implement the pipeline.

Abstract: Systems and methods are disclosed for enabling stateless status checks using collector redirection. A pool of collector devices can enable asynchronous submission to a data collection system, whereby on receipt of data to a collector device, the collector device generates and acknowledgement value for the data. A submitting device can later use the acknowledgement value to obtain the status of processing the data on the collection system. If collector devices are load balanced, operation of a load balancer can cause a request for status to be routed to a different collector device than the device to which data was initially submitted. To address this, collector devices can be configured to use the acknowledgement value to identify another collector device to which data was originally submitted, and to forward status requests to that other device. Status requests can thus be correctly routed without modification to load balancer operation.

Abstract: Methods, apparatuses, and systems are provided for uploading a file in the field of computer technology. The method includes a router receiving a target file for uploading to a target server which is transmitted from a terminal; determining a feature value of the target file; obtaining a list of feature values of files for the target server, in which the feature value of each file stored in the target server is recorded; transmitting the target file to the target server, when the feature value of the target file is not in the list of feature values of files; and transmitting the feature value of the target file to the target server, when the feature value of the target file is in the list of feature values of files.

Abstract: Advanced, but user-friendly composition and editing environments for musical scores may be provided using the types, and in some cases the instances, of computing devices that will in turn consume musical score content so generated. Indeed, by integrating musical composition facilities within synthetic musical instruments that can be widely deployed on hand-held or portable computing devices, a social music network that includes such synthetic musical instruments gains access to a large, and potentially prolific, population of authors, editors and reviewers, as well as to the community-sourced musical scores that they can generate. By curating such content and/or by applying crowd-sourcing or other computational techniques to maintain quality, a social music network may rapidly deploy the new and ever evolving content that its user community desires.

Abstract: A method for text selection includes: determining, in text for selection, a first display position of a start selection point and a first display position of an end selection point, wherein text between the start selection point and the end selection point is target text including at least one character; partitioning the text for selection into a plurality of text blocks based on semantic meaning; receiving a dragging operation corresponding to the start selection point or the end selection point; and changing, according to the dragging operation, the first display position of the start selection point or the first display position of the end selection point to a corresponding second display position in unit of a text block.