Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

Abstract: A woodwind instrument with improved tonal characteristics that plays both in-tune and with a timbre consistent with the rest of the range of notes. The instrument may be an improved saxophone having a tone hole on at least one joined section of the saxophone. The joined section may be a joint between a saxophone body and a upper bow, a joint between a saxophone body and lower bow or both. A connecting ring may be used at the joined section and, if used, will receive the tone hole. A method of improving the tonal characteristics of a saxophone comprises the steps of identifying at least one joint between two sections on said saxophone and soldering a tone hole at the joint. A connecting ring may be soft soldered to the joint.

Abstract: A musical wind instrument, comprising a mouthpiece, key mechanism, body, and an alternative material bridge that is couple a first and second opposite facing tube. There is in an alternative embodiment at least one coupling mechanism affixed to at least one of the opposite facing tubes designed to releasably hold the wood based material bridge against the first and second tubes. Alternatively there is a musical wind instrument made of a predominantly first material, comprising a mouthpiece, key mechanism, and body; at least a first and second tube having a portion thereof being spatially opposite to each other respectively, and a bridge, having a first and second end that are coupled to the first and second tube respectively, wherein the bridge is made of an alternative material that is different from the predominantly first material of the instrument.

Abstract: A musical wind instrument, comprising a mouthpiece, key mechanism, body, and an alternative material bridge that is couple a first and second opposite facing tube. There is in an alternative embodiment at least one coupling mechanism affixed to at least one of the opposite facing tubes designed to releasably hold the wood based material bridge against the first and second tubes. Alternatively there is a musical wind instrument made of a predominantly first material, comprising a mouthpiece, key mechanism, and body; at least a first and second tube having a portion thereof being spatially opposite to each other respectively, and a bridge, having a first and second end that are coupled to the first and second tube respectively, wherein the bridge is made of an alternative material that is different from the predominantly first material of the instrument.

Abstract: A wind instrument with improved tonal characteristics by positioning an octave hole, an octave key mechanism, and/or a water key on a surface of the wind instrument that is not a tone-rich region. The wind instrument may be a woodwind instrument such as a saxophone or a brass instrument such as a trumpet. The octave hole may be placed on a concave portion of a curve in the wind instrument. The octave hole may be covered by an octave key mechanism that opens the octave hole using the same fingering that would open an octave key in a typical wind instrument. The water key may be placed on a portion of the body of the wind instrument that is not a tone-rich region of the wind instrument.

Abstract: A wind instrument with improved tonal characteristics by positioning an octave hole, an octave key mechanism, and/or a water key on a surface of the wind instrument that is not a tone-rich region. The wind instrument may be a woodwind instrument such as a saxophone or a brass instrument such as a trumpet. The octave hole may be placed on a concave portion of a curve in the wind instrument. The octave hole may be covered by an octave key mechanism that opens the octave hole using the same fingering that would open an octave key in a typical wind instrument. The water key may be placed on a portion of the body of the wind instrument that is not a tone-rich region of the wind instrument.