Publication number: 20090098050
Abstract: Disclosed herein are a class of compounds comprising peptides of the sequence (X-Y-Z)n, wherein X is an amino acid selected from aspartic acid, glutamic acid, asparagine, alanine and glutamine, and Y and Z are amino acids selected from alanine, serine, threonine, phosphoserine, phosphothreonine, and their derivatives. These compounds have the property of binding tightly and specifically to calcified surfaces, making them useful for a variety of applications including remineralization of tooth and bone surfaces, diagnosis of bone and tooth defects, treatment of bone and tooth defects, and analysis of the presence and location of calcified deposits both in vitro and in vivo and in industrial, synthetic, medical, dental, and research applications where identification, localization, or manipulation of calcification is desirable.
Type:
Application
Filed:
September 27, 2006
Publication date:
April 16, 2009
Applicant:
THE REGENTS OF THE UNVERSITY OF CALIFORNIA
Inventors:
Daniel Yarbrough, Wenyuan Shi, Elizabeth Hagerman, Sotirios Tetradis, Fengxia Qi, Jian He, Bruce Rutherford, Randal Eckert, Ben Wu
