Patents by Inventor Randall A. Scheuerman

Randall A. Scheuerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PREPARING N6-((2-AZIDOETHOXY)CARBONYL)LYSINE
    Publication number: 20220324792
    Abstract: Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N6-((2-chloroethoxy)carbonyl)-L-lysinate and tert-butyl N6-((2-azidoethoxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysinate, and uses thereof.
    Type: Application
    Filed: June 21, 2022
    Publication date: October 13, 2022
    Applicant: Synthorx, Inc.
    Inventors: Hans AERNI, Randall SCHEUERMAN, Nikolai F. SEPETOV, Alexander V. SHIROKOV
  • Crystalline forms of (N, N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
    Patent number: 9895336
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 20, 2018
    Assignee: XENOPORT, INC.
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • CRYSTALLINE FORMS OF (N, N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE
    Publication number: 20170368014
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 28, 2017
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
    Patent number: 9795581
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: October 24, 2017
    Assignee: XENOPORT, INC.
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • CRYSTALLINE FORMS OF (N, N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE
    Publication number: 20170239206
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
    Patent number: 9682057
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: June 20, 2017
    Assignee: XENOPORT, INC.
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • CRYSTALLINE FORMS OF (N,N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE
    Publication number: 20170042853
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Application
    Filed: July 20, 2016
    Publication date: February 16, 2017
    Applicant: XenoPort, Inc.
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9533941
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: January 3, 2017
    Assignee: XENOPORT, INC.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X. Zhou
  • Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
    Patent number: 9416096
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: August 16, 2016
    Assignee: XenoPort, Inc.
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • METHODS OF SYNTHESIZING A LEVODOPA ESTER PRODRUG
    Publication number: 20160176804
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 23, 2016
    Inventors: STEPHEN P. RAILLARD, ADAM MANN, SURESH K. MANTHATI, RANDALL A. SCHEUERMAN, TONO ESTRADA, MARK Q. NGUYEN, CINDY X. ZHOU
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 9353057
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: May 31, 2016
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Method of making monomethyl fumarate
    Patent number: 9302977
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: April 5, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9290445
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 22, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
  • CRYSTALLINE FORMS OF (N,N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE
    Publication number: 20150073049
    Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 12, 2015
    Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
  • METHOD OF MAKING MONOMETHYL FUMARATE
    Publication number: 20140364604
    Abstract: Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Inventors: Stephen P. Raillard, Randall A. Scheuerman, Suresh K. Manthati
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 8378137
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: February 19, 2013
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
    Publication number: 20120010425
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: August 11, 2011
    Publication date: January 12, 2012
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 8003809
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: August 23, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria J. Ludwikow, Ge Peng, Seema Bhat
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7767649
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: August 3, 2010
    Assignee: XenoPort, Inc.
    Inventors: Randall A. Scheuerman, Mark A. Gallop, Kenneth C. Cundy, Ronald W. Barrett
  • Methods of Synthesizing a Levodopa Ester Prodrug
    Publication number: 20100099907
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Application
    Filed: October 19, 2009
    Publication date: April 22, 2010
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X. Zhou