Patents by Inventor Randall C. Willis

Randall C. Willis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivesicular liposomes utilizing neutral lipids to modify in vivo release
    Patent number: 5962016
    Abstract: The rate of release of encapsulated active compound from a multivesicular liposomal (MVL) formulation is modified by selection of a neutral lipid component. A family of MVL formulations containing different slow:fast release neutral lipid molar ratios display different release rates depending upon the molar ratio of the fast release neutral lipid to the slow release neutral lipid in each member. Incubation in plasma or a plasma-like medium at in vivo temperatures so as to obtain a release rate curve for each allows selection from among the members of the family of a liposomal formulation with a desired rate of release in vivo.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: October 5, 1999
    Assignee: DepoTech Corporation
    Inventor: Randall C. Willis
  • Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
    Patent number: 5891467
    Abstract: The rate of release of encapsulated active compound from a multivesicular liposomal (MVL) formulation is modified by selection of a neutral lipid component. A family of MVL formulations containing different slow:fast release neutral lipid molar ratios display different release rates depending upon the molar ratio of the fast release neutral lipid to the slow release neutral lipid in each member. Incubation in plasma or a plasma-like medium at in vivo temperatures so as to obtain a release rate curve for each allows selection from among the members of the family of a liposomal formulation with a desired rate of release in vivo.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: April 6, 1999
    Assignee: Depotech Corporation
    Inventor: Randall C. Willis