Patents by Inventor Randall E. McClelland

Randall E. McClelland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

Patent number: 8404483

Abstract: A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.

Type: Grant

Filed: September 10, 2010

Date of Patent: March 26, 2013

Assignee: University of North Carolina at Chapel Hill

Inventors: Lola M. Reid, Randall E. McClelland, Joshua Uronis, Hsin-Lei Yao, Eliane Wauthier
Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

Publication number: 20110065188

Abstract: A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.

Type: Application

Filed: September 10, 2010

Publication date: March 17, 2011

Inventors: Lola M. Reid, Randall E. Mcclelland, Joshua Uronis, Hsin-Lei Yao, Eliane Wauthier
EXTRACELLULAR MATRIX COMPONENTS FOR EXPANSION OR DIFFERENTIATION OF HEPATIC PROGENITORS

Publication number: 20100093077

Abstract: A method is provided of propagating hepatic progenitors in vitro on or in one or multiple extracellular matrix components found in the stem cell compartment or niche of liver. A container for the propagation of the progenitors and comprising culture dishes, bioreactors, or lab chips.

Type: Application

Filed: October 2, 2009

Publication date: April 15, 2010

Inventors: Randall E. MCCLELLAND, Lola M. REID
Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

Publication number: 20080318316

Abstract: A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.

Type: Application

Filed: June 13, 2008

Publication date: December 25, 2008

Inventors: Lola M. Reid, Randall E. McClelland, Joshua Uronis, Hsin-Lei Yao, Eliane Wauthier

Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

EXTRACELLULAR MATRIX COMPONENTS FOR EXPANSION OR DIFFERENTIATION OF HEPATIC PROGENITORS

Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same