Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.

Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.

Abstract: Virtual solution architecture for computer data systems. In one aspect, providing an architecture for a computer data system includes creating a virtual solution architecture that includes a plurality of building blocks, each building block characterized by balanced operation, and mapping the virtual solution architecture to a physical solution architecture for the computer data system. Another aspect includes providing at least one balanced configuration unit (BCU) in a computer data system, the BCU including at least one balanced partition unit (BPU) that includes computer resources to provide balanced operation for the BPU.