Abstract: Disclosed herein are therapeutic compounds capable of targeting abroad range of tumor cells. The present disclosure is further directed to compositions comprising the therapeutic compounds, methods of manufacturing the therapeutic compounds, and methods of treating cancer comprising administering the therapeutic compounds.

Abstract: A heater operates at a first power to heat a space and a second power to maintain the temperature. The heater uses a first heating element and a second heating element, which are configured to automatically supply the first power during an initial heating period, then step down to the second power for continuous operation. The heater may use a phase chopper circuit and heating element; switched diode and heating element; positive temperature coefficient thermostat, isolated heater, and heating element; latching mechanical timer switch and heating element; and/or a positive temperature coefficient heating element and multi-speed fan to provide dual power levels. The heater may include a first heating element energized during a portion of a heating cycle and a second heating element continuously energized during the heating cycle. The heating cycle is repeated for a period after which both elements are de-energized.